Testagen
Khavinson synthetic tripeptide bioregulator targeting testicular tissue — studied for testosterone production support and Leydig cell function restoration in aging males.
🔬 Mechanism of Action
Testagen is a synthetic tripeptide bioregulator targeting testicular Leydig and Sertoli cells, designed based on sequences isolated from testicular tissue that showed the highest gene-activating potency for steroidogenic enzymes.
Testagen modulates gene expression for (1) steroidogenic acute regulatory protein (StAR) — the rate-limiting step in testosterone biosynthesis, (2) CYP11A1 (cholesterol side-chain cleavage enzyme), (3) 3β-HSD and 17β-HSD (enzymes converting pregnenolone to testosterone), and (4) inhibin B production by Sertoli cells reflecting spermatogenic capacity.
In aged male rats, 10-day Testagen courses restored testicular StAR expression to 70-80% of young adult levels. Testagen is the synthetic counterpart to Testoluten (the natural testicular Cytomax extract).
Source: PMID: 15677927
📜Background & History
Testagen targets testicular Leydig cells for testosterone biosynthesis gene expression.
🎯 Research Use Cases
- ✓Male hormonal health
- ✓Age-related testosterone decline support
- ✓Hormone optimization protocols
💉 Dosing Protocol
| Typical Dose | 10-20 mg/day (oral) or 1-2 mg SC |
| Frequency | 1× daily for 10-30 day cycles |
| Half-Life | ~30 minutes (estimated) |
| Common Vial Sizes | 5 mg, 10 mg |
🧪 Reconstitution Example
⚠️Safety & Considerations
Standard Khavinson protocol. Can be combined with Testoluten (testicular Cytomax extract) for comprehensive male reproductive support.
⚡Interactions & Contraindications
Standard Khavinson protocol. Monitor testosterone levels.
🔗Synergies & Common Stacks
Testagen (synthetic) + Testoluten (testicular Cytomax) = layered male reproductive bioregulator support.