GLOW Stack
The GLOW stack is a three-peptide regenerative blend of GHK-Cu, BPC-157, and TB-500 targeting skin quality, collagen production, tissue healing, and systemic inflammation reduction.
🔬 Mechanism of Action
The GLOW stack is a three-peptide synergistic blend designed for regenerative, aesthetic, and recovery outcomes. Each component targets distinct but complementary biological pathways:
**GHK-Cu (Copper peptide)** GHK-Cu (Glycyl-L-histidyl-L-lysine:copper) is a naturally occurring tripeptide found in human plasma that declines significantly with age. It stimulates collagen type I, III, and IV synthesis via upregulation of decorin (a collagen-organizing proteoglycan). It promotes elastin production and glycosaminoglycan synthesis, improving skin thickness, firmness, and hydration. GHK-Cu also upregulates superoxide dismutase (SOD) — the body's primary antioxidant enzyme — and has been shown to stimulate hair follicle cycling by extending the anagen (growth) phase.
**BPC-157 (Body Protection Compound-157)** BPC-157 is a synthetic gastric pentadecapeptide that upregulates VEGF (Vascular Endothelial Growth Factor) and FGF to drive angiogenesis — formation of new blood vessels — at repair sites. It activates fibroblast migration to wounds and upregulates the nitric oxide (NO) system, enhancing blood flow and tissue oxygenation. BPC-157 also modulates the EGFR (epidermal growth factor receptor) and promotes tendon-to-bone healing in animal models.
**TB-500 (Thymosin Beta-4 fragment)** TB-500 promotes actin polymerization and sequestration — a key step in cell migration to wound sites. It stimulates vessel endothelial cell migration (angiogenesis), promotes stem cell recruitment, and reduces pro-inflammatory cytokines. Unlike BPC-157 which works best locally, TB-500 distributes systemically, making it effective for remote injuries and diffuse inflammation.
**Synergy**: GHK-Cu rebuilds the extracellular matrix; BPC-157 provides the vascular infrastructure; TB-500 drives systemic cell migration. Together they cover all three axes of tissue regeneration.
Source: PMID: 18492131 (GHK-Cu), PMID: 29936067 (BPC-157), PMID: 20435714 (TB-500)
💉 Dosing Protocol
| Typical Dose | BPC-157 250 mcg/day · TB-500 2.5 mg 2×/wk · GHK-Cu 1–2 mg/day |
| Frequency | Daily (GHK-Cu, BPC-157) · 2× weekly (TB-500) |
| Half-Life | Mixed (1.5–4 hours per component) |
| Common Vial Sizes | 5 mg, 10 mg, 50 mg |
🧪 Reconstitution Example
⚠️Safety & Considerations
All three GLOW stack components are research peptides not FDA-approved for human use. Animal studies show favorable safety profiles with no significant toxicity. Due to the angiogenic properties of BPC-157 and TB-500, this stack should not be used by individuals with active malignancies. GHK-Cu is generally well-tolerated; topical use has a decades-long cosmetic safety record. Use sterile bacteriostatic water and insulin syringes for reconstitution. Rotate injection sites daily.
