Comparison
Semaglutide vs Liraglutide
Side-by-side attributes from our library comparison data. Read each peptide leaf for dosing math, regulatory status, and citations.
Semaglutide vs. Liraglutide
| Attribute | Semaglutide | Liraglutide |
|---|---|---|
| Mechanism | GLP-1 agonist | GLP-1 agonist (same class) |
| Peak Weight Loss | 14.9–17% | ~8% (SCALE trial) |
| Dosing Schedule | Once weekly injection | Daily injection |
| FDA Approval | Ozempic® / Wegovy® | Victoza® (T2D) / Saxenda® (obesity) |
| Cardiovascular | Proven CV risk reduction (SUSTAIN-6) | Proven CV risk reduction (LEADER) |
| Convenience | High - once weekly dosing | Low - daily injection required |
Verdict: Semaglutide is the clear successor to liraglutide: superior weight loss, once-weekly dosing convenience, and comparable safety profile. Liraglutide is primarily used today where semaglutide is unavailable or not covered.