Immune & Thymic

Ac-SDKP

N-acetyl-Ser-Asp-Lys-Pro · acetyl-SDKP · goralatide

Endogenous N-acetylated tetrapeptide (N-acetyl-Ser-Asp-Lys-Pro) cleaved from thymosin β4 and regulated by ACE. Studied for antifibrotic and hematopoietic effects in animals and translational work. Research SKU. Not TB-500. Not an ACE-inhibitor substitute.

Not FDA-approved - research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: September 2026Evidence: Low
Typical research dose
Research - no established human research-chem dose
Frequency
Not established
Half-life
Minutes-class (ACE-cleaved)
Common vials
5 mg
CAS
127103-11-1
Molecular weight
~487.5 g/mol

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Injury & tissue2.5/10

    Antifibrotic and hematopoietic papers exist. No honest research-chem human dose. Mechanism band after haircut: 2.5.

Compound card

Sequence
N-acetyl-Ser-Asp-Lys-Pro
Class
Endogenous ACE-regulated tetrapeptide (Ac-SDKP / goralatide lineage)
Formula
C20H33N5O9
Status
Not FDA-approved · research use
Dose it
5 mg + 2 mL BAC water → 2.5 mg/mL · 100 mcg ≈ 4 units (U-100)
Open in calculator

How it works

Ac-SDKP (N-acetyl-Ser-Asp-Lys-Pro) is an endogenous tetrapeptide generated from thymosin β4 and degraded by angiotensin-converting enzyme (ACE). Classical hematology work and later fibrosis models made it a research target. It is not TB-500 (the commercial 7-mer), not an ACE inhibitor, and not a reason to inject a research vial as a fibrosis drug.

ACE inhibitors raise endogenous Ac-SDKP — that is pharmacology context, not a dosing chart for a gray-market peptide.

Source: Ac-SDKP / goralatide literature; endogenous peptide regulated by ACE

Research Use Cases

  • ✓Catalog identity: Moderate
  • ✓Clinical fibrosis care: Low

Dosing

PhaseDoseFrequencyNotes
HumanNone established for research SKUsn/aDo not invent milligrams from ACE-inhibitor papers.

Administration

Route / form
Research only — not a labeled route
Timing
Not established
Empty stomach?
No - Food timing is not critical.

Timeline

Translational papers
Fibrosis and hematopoietic endpoints in models — not a week-1 forum schedule.

Who it is for

Catalog identity

Moderate

Useful next to TB-500 / Tβ4 for people who confuse the names.

Clinical fibrosis care

Low

Wrong tool.

Reconstitution

VialWaterConcentrationExample dose
5 mg lyophilized (if that is the SKU)2.0 mL BAC2.5 mg/mLIdentity math only. No established human dose.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research tetrapeptide. Unknown purity on gray-market vials. Hematopoietic and fibrosis signaling is not casual recovery stacking. Not for pregnancy.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • No established human research-chem dose on this leaf.
  • Not TB-500. Not full thymosin β4.
  • ACE-inhibitor effects on endogenous Ac-SDKP are not a peptide injection schedule.
  • This site will not treat organ fibrosis or bone-marrow disease from this page.

Verdict

Ac-SDKP is an endogenous ACE-regulated tetrapeptide with antifibrotic and hematopoietic research history. It is not TB-500 and not a DIY fibrosis protocol.

Interactions & Contraindications

Research tetrapeptide. Unknown purity on gray-market vials. Hematopoietic and fibrosis signaling is not casual recovery stacking. Not for pregnancy.

Frequently Asked Questions

Is Ac-SDKP the same as TB-500?▼
No. TB-500 as sold is usually Ac-LKKTETQ. Ac-SDKP is a different tetrapeptide regulated by ACE.
Do ACE inhibitors replace this peptide?▼
ACE inhibitors can raise endogenous Ac-SDKP. That is not a reason to inject a research vial, and this page is not hypertension advice.

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