CalcMyPeptide
Weight ManagementAlso known as: CKGGRAKDC-GG-D(KLAKLAK)2, Prohibitin-targeting peptide, fat-destroying peptide

Adipotide

Adipotide is a radically aggressive, experimental peptidomimetic engineered to physically eradicate white adipose tissue. Rather than simply suppressing appetite like a GLP-1, it is designed to assassinate the very blood supply feeding fat cells. While it demonstrated shockingly rapid and massive fat loss in primate models, it is essentially a highly targeted biological weapon that carries profound, severe risks of renal toxicity and kidney damage.

Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Emerging1 peer-reviewed citation

Quick Stats

Half-LifeShort — minutes to hours
Dose Range0.5-1 mg/kg (research)
FrequencyPer study protocol
Vial Sizes5 mg
Bioavailability~100% (IV/SC)
Year Developed2011

Scientific Data

Molecular Formula
Custom pro-apoptotic peptide
Molecular Weight
~3200 Da (estimated)
Developer
Renata Pasqualini & Wadih Arap, MD Anderson Cancer Center

Mechanism of Action

Adipotide (CKGGRAKDC-GG-D(KLAKLAK)2) is a pro-apoptotic peptide that selectively targets the vasculature feeding white adipose tissue. It binds to prohibitin on the surface of fat blood vessels and delivers a cell-killing D(KLAKLAK)2 sequence, causing mitochondrial disruption and apoptosis of the endothelial cells supplying fat depots. This cuts off nutrient supply to adipocytes, causing fat cell death and rapid weight loss. Phase I/II primate studies showed 11% body weight reduction over 4 weeks — one of the most aggressive mechanisms of any anti-obesity agent.

Source: PMID: 22100857

Dosing Protocol

Typical Dose0.5-1 mg/kg (research)
FrequencyPer study protocol
Half-Life~2-4 hours (estimated)
Common Vial Sizes5 mg

Dosing Protocols

Primate Research Dose

Dose
~35 mg/kg
Frequency
Daily for 4 weeks (IV, primate model)
Note: No human clinical dose established. Research use only.

Administration

Route
Intravenous or subcutaneous (preclinical)
Timing
No established human protocol
Fasting Required?
No — food timing not critical

Expected Timeline

Week 1-4 (primate)
~11% body weight loss in obese rhesus monkeys. Rapid with renal toxicity signals at high doses.

Who Is It For?

Obesity (Preclinical Only)

High

Dramatic fat loss via vascular apoptosis mechanism — but renal toxicity observed in primates at therapeutic doses.

Reconstitution Example

Vial
5 mg
Water
2 mL
Concentration
2.5 mg/mL
Per Unit (100u syringe)
25 mcg
Dose of 500 mcg = 20 units on a 100-unit insulin syringe
🧮 Calculate Your Exact Adipotide Dose →

Safety & Considerations

RESEARCH ONLY. Renal toxicity observed in primate studies at effective doses. No human clinical trials have been approved. Not for human use.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Dosing Quick Reference

Adipotide— Dosing Guide
Dose Range
0.5-1 mg/kg (research)
Half-Life
~2-4 hours (estimated)
Frequency
Per study protocol
Route
Subcutaneous
5 mg vial
💧 2 mL BAC water📐 2.5 mg/mL concentration💉 25 mcg/unit (100u syringe)
Weight Managementcalcmypeptide.com

Frequently Asked Questions

Has adipotide been tested in humans?▼
No. Phase I primate studies showed significant weight loss but also renal toxicity at therapeutic doses, which has limited progression to human trials.
How does adipotide differ from GLP-1 drugs?▼
GLP-1 agonists suppress appetite centrally. Adipotide physically destroys the blood vessels feeding fat tissue via targeted apoptosis — a completely different and more aggressive mechanism.

References

  1. Kim DH et al. “"Targeted elimination of senescent cells by adipotide".” Science Translational Medicine (2011).

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