AntimicrobialAlso known as: Human Neutrophil Peptide 1, HNP-1, DEFA1
α-Defensin 1 (HNP-1)
Endogenous 29-amino acid antimicrobial peptide found in neutrophil azurophilic granules — among the most abundant proteins in human neutrophils. Research tool for innate immunity studies.
Half-Life
~2-4 hours (estimated)
Dose Range
Research only
Frequency
Per study protocol
Vial Sizes
1 mg
Mechanism of Action
Cysteine-rich peptide forming a β-sheet structure with a central hydrophobic core. Inserts into microbial membranes creating voltage-dependent ion channels. Also recruits and activates dendritic cells, linking innate to adaptive immunity.
Source: PMID: 12379468
Dosing Protocol
| Typical Dose | Research only |
| Frequency | Per study protocol |
| Half-Life | ~2-4 hours (estimated) |
| Common Vial Sizes | 1 mg |
Dosing Quick Reference
α-Defensin 1 (HNP-1)— Dosing Guide
Dose Range
Research only
Half-Life
~2-4 hours (estimated)
Frequency
Per study protocol
Route
Oral
1 mg vial
Antimicrobialcalcmypeptide.com
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