Enclomiphene
Androxal · EN-CLO · trans-clomiphene
Enclomiphene is the ultra-purified trans-isomer of traditional Clomid (clomiphene citrate), stripped entirely of the toxic, emotionally destabilizing Zuclomiphene isomer. It is universally regarded as the premier modern SERM for advanced male hormone optimization. By aggressively tricking the brain into sensing a zero-estrogen environment, it forces massive endogenous testosterone production without causing the testicular shrinkage or infertility guaranteed by traditional TRT injections.
Use-case scores
0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.
- Sexual / hormonal5.5/10
SERM that raises LH/FSH/T in men in published work. Not FDA-approved as Androxal as of this review. Not clomiphene racemate 1:1. Small-human / development: 5.5.
Compound card
- Class
- Trans-clomiphene SERM (not a peptide)
- Formula
- C26H28ClNO
- Status
- Not FDA-approved · research use
How it works
Enclomiphene is the trans-isomer of clomiphene citrate - a selective estrogen receptor modulator (SERM). While clomiphene is a mixture of zuclomiphene (cis) and enclomiphene (trans), enclomiphene provides the primary testosterone-stimulating effect by blocking estrogen receptors in the hypothalamus and pituitary, triggering increased LH and FSH secretion. This stimulates testicular testosterone production while preserving spermatogenesis - making it a preferred alternative to exogenous testosterone for men who wish to maintain fertility. Enclomiphene is specifically studied as a standalone SERM for secondary hypogonadism.
Source: PMID: 23602453 (Phase 3)
Research Use Cases
- ✓Secondary Hypogonadism: High
- ✓Post-Cycle Therapy (PCT): High
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Standard | 12.5 - 25 mg | Once daily (oral) | Used for secondary hypogonadism and PCT (post-cycle therapy). Dose guided by follow-up T levels. |
Administration
Timeline
Who it is for
Secondary Hypogonadism
HighRaises testosterone while preserving fertility - preferred over TRT for men wanting to conceive.
Post-Cycle Therapy (PCT)
HighRapidly restores HPG axis function after anabolic steroid cycles.
Safety & Considerations
Not FDA-approved as a standalone drug (NDA rejected 2015 but re-filed). Available compounded. Avoid in active or history of thromboembolic events. Monitor vision (rare visual disturbances). Do not use with exogenous testosterone.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- Not FDA-approved testosterone replacement as of 2026-08-31.
- This site will not treat hypogonadism from an enclomiphene page.
Verdict
Enclomiphene is a SERM, not a peptide. We list it because TRT-adjacent searchers land here. It is not hCG and not a secretagogue. Fertility and hematocrit conversations belong with a clinician.
Interactions & Contraindications
Not FDA-approved as a standalone drug (NDA rejected 2015 but re-filed). Available compounded. Avoid in active or history of thromboembolic events. Monitor vision (rare visual disturbances). Do not use with exogenous testosterone.
Appears in goal guides
Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.
Frequently Asked Questions
Is enclomiphene better than clomid for testosterone?▼
Can enclomiphene replace TRT?▼
References
- Kim ED et al. “"Enclomiphene citrate stimulates testosterone production".” BJU International (2016). PMID: 26496621
Looking for a trusted source? See our recommended suppliers
Independently tested · COA-verified · Save 10% with our exclusive code