Hormone SupportAlso known as: Androxal, EN-CLO, trans-clomiphene
Enclomiphene
Trans-isomer of clomiphene citrate — a selective estrogen receptor modulator (SERM) that boosts endogenous testosterone by blocking hypothalamic estrogen feedback. Used off-label for secondary hypogonadism as a TRT alternative.
Half-Life
~10 hours
Dose Range
12.5-25 mg/day (oral)
Frequency
1× daily (oral)
Vial Sizes
N/A (oral)
Mechanism of Action
Competitively blocks estrogen receptors in the hypothalamus and pituitary, removing negative feedback. The resulting increase in GnRH pulse frequency raises FSH and LH, stimulating Leydig cell testosterone production while preserving spermatogenesis.
Source: PMID: 23602453 (Phase 3)
Dosing Protocol
| Typical Dose | 12.5-25 mg/day (oral) |
| Frequency | 1× daily (oral) |
| Half-Life | ~10 hours |
Dosing Quick Reference
Enclomiphene— Dosing Guide
Dose Range
12.5-25 mg/day (oral)
Half-Life
~10 hours
Frequency
1× daily (oral)
Route
Oral
Hormone Supportcalcmypeptide.com
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