Hormone SupportAlso known as: Androxal, EN-CLO, trans-clomiphene

Enclomiphene

Enclomiphene is the ultra-purified trans-isomer of traditional Clomid (clomiphene citrate), stripped entirely of the toxic, emotionally destabilizing Zuclomiphene isomer. It is universally regarded as the premier modern SERM for advanced male hormone optimization. By aggressively tricking the brain into sensing a zero-estrogen environment, it forces massive endogenous testosterone production without causing the testicular shrinkage or infertility guaranteed by traditional TRT injections.

Reviewed by CalcMyPeptide Editorial Team

·Last updated: April 2026·Evidence: Moderate·1 peer-reviewed citation

Quick Stats

Half-Life~5-7 hours (shorter than zuclomiphene)

Dose Range12.5-25 mg/day (oral)

Frequency1× daily (oral)

Vial SizesN/A (oral)

BioavailabilityHigh (oral)

Year Developed2013 (isomer isolation)

Scientific Data

Molecular Formula

C26H28ClNO

Molecular Weight

406.0 g/mol

CAS Number

7599-79-3

Developer

Originally from Merrell Dow; purified isomer by Repros Therapeutics

Mechanism of Action

Enclomiphene is the trans-isomer of clomiphene citrate — a selective estrogen receptor modulator (SERM). While clomiphene is a mixture of zuclomiphene (cis) and enclomiphene (trans), enclomiphene provides the primary testosterone-stimulating effect by blocking estrogen receptors in the hypothalamus and pituitary, triggering increased LH and FSH secretion. This stimulates testicular testosterone production while preserving spermatogenesis — making it a preferred alternative to exogenous testosterone for men who wish to maintain fertility. Enclomiphene is specifically studied as a standalone SERM for secondary hypogonadism.

Source: PMID: 23602453 (Phase 3)

Dosing Protocol

Typical Dose	12.5-25 mg/day (oral)
Frequency	1× daily (oral)
Half-Life	~10 hours

Dosing Protocols

Standard

Dose

12.5 - 25 mg

Frequency

Once daily (oral)

Note: Used for secondary hypogonadism and PCT (post-cycle therapy). Dose guided by follow-up T levels.

Administration

Route

Oral capsule

Timing

Once daily, any time. No fasting required.

Fasting Required?

No — food timing not critical

Expected Timeline

Week 1-2

LH and FSH elevation begins. Testosterone starts rising.

Week 4-8

Testosterone often reaches mid-to-upper normal range (400-700 ng/dL typical).

Who Is It For?

Secondary Hypogonadism

High

Raises testosterone while preserving fertility — preferred over TRT for men wanting to conceive.

Post-Cycle Therapy (PCT)

High

Rapidly restores HPG axis function after anabolic steroid cycles.

Safety & Considerations

Not FDA-approved as a standalone drug (NDA rejected 2015 but re-filed). Available compounded. Avoid in active or history of thromboembolic events. Monitor vision (rare visual disturbances). Do not use with exogenous testosterone.

Regulatory & Legal Status

FDA Status (US)

Research Only

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Dosing Quick Reference

Enclomiphene— Dosing Guide

Dose Range

12.5-25 mg/day (oral)

Half-Life

~10 hours

Frequency

1× daily (oral)

Route

Oral

Hormone Supportcalcmypeptide.com

Frequently Asked Questions

Is enclomiphene better than clomid for testosterone?▼

Enclomiphene is the active isomer responsible for testosterone stimulation. By removing the zuclomiphene isomer (which accumulates and causes side effects like mood swings), enclomiphene provides a cleaner response with fewer estrogenic side effects.

Can enclomiphene replace TRT?▼

For men with secondary hypogonadism (pituitary-driven low T), enclomiphene can raise testosterone to normal ranges while preserving sperm production. It does not work for primary hypogonadism (testicular failure).

References

Kim ED et al. “"Enclomiphene citrate stimulates testosterone production".” BJU International (2016). PMID: 26496621

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