GHRP-2
Growth Hormone Releasing Peptide 2
GHS-R1a hexapeptide (pralmorelin). Stronger GH pulse than GHRP-6, still cortisol/prolactin. Diagnostic pralmorelin is not a 5 mg research cake.
Use-case scores
0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.
- Muscle / recomp3.5/10
Potent GH pulse, still community reconstitution. Not a US anabolic label.
Compound card
- Sequence
- D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2 (pralmorelin)
- Class
- GHS-R1a hexapeptide (pralmorelin; diagnostic use exists outside this SKU)
- Formula
- C45H55N9O6
- Status
- Not FDA-approved · research use
How it works
GHRP-2 is a synthetic hexapeptide and second-generation growth hormone releasing peptide. It is the most potent of the GHRP family for GH release. Like GHRP-6, it activates the ghrelin receptor (GHS-R1a), but with a higher binding affinity. GHRP-2 produces stronger GH pulses than GHRP-6 with a moderately lower appetite stimulation effect (though still greater than Ipamorelin).
GHRP-2 also elevates cortisol and prolactin more than Ipamorelin but less than Hexarelin. It does not exhibit desensitization at standard doses over typical cycle lengths.
Source: PMID: 9003422
Background & History
GHRP-2 (pralmorelin) is a stronger GHS-R1a hexapeptide than GHRP-6. Diagnostic pralmorelin is not a 5 mg research cake. Cortisol/prolactin still happen.
Research Use Cases
- ✓Pralmorelin identity vs GHRP-6 vs ipamorelin
- ✓Diagnostic GH-stimulation history vs daily biohack use
- ✓Not a hypertrophy NDA
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Standard Protocol | 100 - 300 mcg | 2-3× daily | Inject fasted. Moderate appetite stimulation. Pre-bed and waking doses are most popular. |
Administration
Timeline
Who it is for
GH Optimization (Max Output)
HighMost potent GHRP by raw GH release. Best for users who want maximum secretagogue effect.
Body Recomposition
ModerateStrong GH pulse with moderate appetite effect - middle ground between GHRP-6 and Ipamorelin.
Reconstitution
| Vial | Water | Concentration | Example dose |
|---|---|---|---|
| 5 mg lyophilized | 2.5 mL BAC | 2 mg/mL | 200 mcg = 0.10 mL = 10 units on a U-100. |
Change vial size or water volume? Open the reconstitution calculator.
Safety & Considerations
Research peptide. Moderately stimulates appetite, cortisol, and prolactin. Less appetite stimulation than GHRP-6 but more than Ipamorelin. Use on an empty stomach for optimal GH pulse.
Regulatory & Legal Status
Competitive athletes subject to anti-doping controls should not use GHRP-2.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- Do not paste pediatric diagnostic protocols onto a wellness vial.
- “Most potent GHRP” is a ranking meme, not a reason to skip cycling or glucose watching.
Verdict
GHRP-2 (pralmorelin) is the stronger, still-messy GHRP. Diagnostic pralmorelin is not a 5 mg research cake. Cortisol/prolactin are quieter than hexarelin, louder than ipamorelin.
Interactions & Contraindications
Cortisol/prolactin vs ipamorelin. Empty stomach. Not for a “clean” long-term secretagogue story.
Synergies & Common Stacks
Same dual-receptor idea as other GHRPs. More pulse, more off-target. Not a labeled anabolic stack.
Frequently Asked Questions
Is GHRP-2 stronger than GHRP-6?▼
What is the GHRP-2 dosing protocol?▼
References
- Bowers CY “"Growth hormone-releasing peptides".” Journal of Pediatric Endocrinology & Metabolism (1993). PMID: 8186715
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