Healing & Recovery

Gonadorelin

GnRH · LHRH · Luteinizing Hormone-Releasing Hormone

Gonadorelin is synthetic native GnRH (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2). Pulsatile pumps (historical Lutrepulse) and diagnostic Factrel are the medical story. Community twice-weekly TRT “preservation” shots are not that pump. Continuous exposure downregulates the axis. Score it as hormonal, not as a recovery peptide just because the catalog filed it there.

WADA (S4) - prohibited in sport at all times
Reviewed by CalcMyPeptide Editorial Team
Last updated: August 2026Evidence: Strong3 peer-reviewed citations
Typical research dose
100-500 mcg/day
Frequency
1-2× daily
Half-life
~2–4 min IV; ~10–40 min SC (native GnRH class)
Common vials
2 mg
CAS
33515-09-2
Molecular weight
1182.31 g/mol

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Sexual / hormonal7/10

    Native GnRH is a real diagnostic and pulsatile-fertility drug class. Ceiling 9 for approved use; haircut because twice-weekly TRT folklore is not Lutrepulse and Factrel is not a research-chem PCT kit.

Compound card

Sequence
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Class
Native-sequence GnRH (diagnostic / pulsatile pump drug class)
Formula
C55H75N17O13
Status
FDA-approved
Dose it
2 mg + 2 mL BAC water → 1 mg/mL · 100 mcg ≈ 10 units (U-100)
Open in calculator

How it works

Gonadorelin is synthetic native GnRH, the hypothalamic decapeptide Schally sequenced in 1971 (Science, PMID 4938639). Pulsatile exposure releases LH and FSH. Continuous exposure downregulates the pituitary. That second fact is why depot agonists (leuprolide, triptorelin depot) chemically castrate, and why a research-chem daily drip is the wrong shape.

Factrel was a US diagnostic. Lutrepulse-style pumps dosed micrograms every ~90 minutes for hypogonadotropic hypogonadism. Community twice-weekly 100 mcg next to a testosterone shot is not that pump. It is a hope that a sparse pulse preserves testicular volume. hCG is the more common TRT adjunct with a different mechanism (LH-receptor agonist at the testis, skipping the pituitary).

This catalog files gonadorelin under recovery. Score it sexual/hormonal. It does not repair tendons.

Source: PMID: 1903034

Pulse vs suppression

Native GnRH only stimulates when it is pulsatile. A second peptide on this site, triptorelin, is the long agonist that can do the opposite. Do not stack them as a “restart.”

Goal context

TRT and fertility

Exogenous testosterone suppresses LH/FSH. Preserving spermatogenesis is a clinic problem (hCG, FSH, pulsatile GnRH pumps). A twice-weekly research shot is not a fertility program.

Not triptorelin

Triptorelin is a D-Trp6 agonist with depot cancer labels. Native gonadorelin is shorter-acting. Mixing them is how people accidentally shut the axis down.

Background & History

Gonadorelin is synthetic native GnRH (Schally 1971). Pulsatile exposure releases LH/FSH; continuous exposure downregulates. Factrel was a diagnostic. Lutrepulse-style pumps fire micrograms every ~90 min. Community twice-weekly TRT shots are not that pump. Filed under recovery in this catalog; physiology is HPG.

Research Use Cases

  • ✓Native GnRH identity (vs triptorelin depot agonists)
  • ✓Historical diagnostic bolus / pulsatile pump medicine
  • ✓Not a proven twice-weekly fertility-preservation protocol on TRT

Dosing

PhaseDoseFrequencyNotes
Diagnostic (historical Factrel class)100 mcgSingle IV or SC bolusStimulation test, not a cycle.
Community TRT adjunct (unlabeled)100 mcg2× weekly SCFolklore next to testosterone. Not Lutrepulse. Not proven equivalent to hCG.
Pump medicine (clinician)1–20 mcgEvery ~90 minThis is the actual pulsatile therapy shape. Not a reconstitution-calculator default.

Administration

Route / form
Subcutaneous (community) or IV (diagnostic). Pump therapy is a device, not a weekly vial.
Timing
If used with TRT, people match injection days. That is habit, not PK.
Empty stomach?
No - Food timing is not critical.

Timeline

Minutes after a pulse
LH/FSH can rise. That is physiology, not a PCT guarantee.
Weeks of twice-weekly community use
No adequate trial that this preserves fertility on TRT. Do not skip semen analysis because a peptide page sounded confident.

Who it is for

Need native GnRH identity

High

This is the decapeptide. Diagnostic and pump literature live here.

Need a depot agonist

Low

That is triptorelin/leuprolide. Different page, opposite chronic effect.

Reconstitution

VialWaterConcentrationExample dose
2 mg2.0 mL BAC1 mg/mL100 mcg = 0.10 mL = 10 units on a U-100 syringe

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Native GnRH class. Diagnostic and pump use have medical safety files. Research-chem vials do not. Continuous exposure suppresses the axis. This is not a tendon peptide. Fertility care belongs with an endocrinologist.

Regulatory & Legal Status

FDA Status (US)
Approved

FDA-approved as Factrel®; widely used off-label as Gonadorelin Acetate in TRT protocols

WADA Status (2026)
Prohibited (S4)

Competitive athletes subject to anti-doping controls should not use Gonadorelin.

Classification

Compounded Drug (Rx)

US Compounding: Available via licensed pharmacy Rx

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • Factrel diagnostic approval is not a TRT-adjunct label for gray-market vials.
  • Pulsatile pump data (every ~90 min) does not transfer to twice-weekly community shots.
  • Continuous or high-frequency exposure can suppress LH/FSH. That is the agonist-depot trick, not a feature of “more is better.”
  • No recovery/tendon indication. Miscategorized in this catalog’s filter, not in physiology.

Verdict

Gonadorelin is native GnRH. Use a pump or a diagnostic protocol if that is the medical job. Do not treat 100 mcg twice a week as proven fertility preservation, and do not file this as a recovery peptide.

Interactions & Contraindications

Continuous or high-frequency exposure can suppress LH/FSH. That is the depot-agonist trick. hCG acts at the testis, skipping the pituitary. Antiandrogens blunt downstream testosterone.

Synergies & Common Stacks

+ Triptorelin →

Do not stack them as a restart. Native pulses vs long-agonist suppression are opposite chronic jobs.

Frequently Asked Questions

Is gonadorelin the same as triptorelin?▼
No. Gonadorelin is native GnRH. Triptorelin is a long D-Trp6 agonist. Depots suppress. Native pulses stimulate if they stay pulsatile.
Does twice-weekly gonadorelin preserve fertility on TRT?▼
It is a common compounding habit. It is not the pulsatile-pump evidence base. hCG acts at the testis. Get semen analysis, not forum certainty.
Why is the half-life so short?▼
Native GnRH is built to be a pulse. Minutes-class clearance is the point. That is why pumps fire every ~90 minutes.
How do I reconstitute a 2 mg vial?▼
Add 2.0 mL BAC for 1 mg/mL. 100 mcg is 0.10 mL (10 units). Use the calculator if you change water volume.
Is Factrel still a thing?▼
Factrel was a US diagnostic gonadorelin product. Availability has shifted. Historical approval is not a research-chem catalog stamp.
Can I use it for PCT instead of a SERM?▼
PCT is a clinic protocol. Sparse GnRH shots are not a Clomid replacement RCT. Continuous agonist exposure can delay recovery.
Why is this in the recovery category?▼
Catalog history. Physiology is HPG. The score bar is sexual/hormonal, not injury.
WADA?▼
Peptide hormones and releasing factors can be prohibited. Do not assume allowed.

References

  1. Schally AV, Arimura A, Kastin AJ, Matsuo H, et al. “Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones.” Science (1971). PMID: 4938639
  2. Conn PM, Crowley WF Jr “Gonadotropin-releasing hormone and its analogues.” N Engl J Med (1991). PMID: 1984190
  3. Al-Inany HG, et al. “GnRH agonist and antagonist treatment protocols for assisted reproduction.” Cochrane Database Syst Rev (2016). PMID: 27126581

📚 Related Articles

How to Reconstitute Peptides: A Complete Step-by-Step Guide (2026)
12 min read • Guide

Looking for a trusted source? See our recommended suppliers

Independently tested · COA-verified · Save 10% with our exclusive code

See suppliers →
← Back to Peptide Library