Hexarelin
Examorelin
Potent GHS-R1a hexapeptide (examorelin) with documented desensitization. Cardiac papers are not a DIY heart protocol. Cycle language exists because the receptor fades.
Use-case scores
0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.
- Muscle / recomp3.5/10
Strong GH pulse plus cortisol/prolactin plus tachyphylaxis. Community ceiling. Cardiac papers are not a gym indication.
Compound card
- Sequence
- His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 (examorelin)
- Class
- Potent GHS-R1a hexapeptide with documented desensitization
- Formula
- C50H69N15O9
- Status
- Not FDA-approved · research use
How it works
Hexarelin is the most potent ghrelin receptor agonist in the GHRP family, producing the strongest GH release pulse. However, it is also the most non-selective, causing significant elevations in cortisol and prolactin. Uniquely, Hexarelin has documented cardioprotective properties - it directly protects cardiac tissue through mechanisms independent of GH release.
The major limitation of Hexarelin is desensitization: continuous use beyond approximately 4 weeks leads to diminishing GH response as receptors downregulate. This necessitates cycling protocols.
Source: PMID: 12165110
Background & History
Hexarelin (examorelin) is a potent GHS-R1a hexapeptide with documented desensitization. Cardiac CD36 papers are not a DIY heart protocol.
Research Use Cases
- ✓Potent GHRP identity and why cycles exist
- ✓Not a post-infarction or cardioprotection treatment page
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Standard Protocol (4-week cycle) | 100 - 200 mcg | 1-2× daily | Cycle off after 4 weeks to prevent receptor desensitization. 2-4 week break required. |
Administration
Timeline
Who it is for
Short-Burst GH Maximization
HighMost potent GHRP GH pulse in brief 4-week cycles before desensitization.
Cardiac Health
ModerateDocumented cardioprotective effects independent of GH release via CD36 receptor.
Reconstitution
| Vial | Water | Concentration | Example dose |
|---|---|---|---|
| 2 mg lyophilized | 2.0 mL BAC | 1 mg/mL | 100 mcg = 0.10 mL = 10 units on a U-100. |
Change vial size or water volume? Open the reconstitution calculator.
Safety & Considerations
Research peptide. Subject to receptor desensitization - cycle 4 weeks on, 2-4 weeks off. Significantly elevates cortisol and prolactin. Has cardioprotective properties independent of GH.
Regulatory & Legal Status
Competitive athletes subject to anti-doping controls should not use Hexarelin.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- Cardioprotective papers are not a reconstitution indication.
- Continuous daily use is the wrong way to read a desensitizing secretagogue.
Verdict
Hexarelin hits hard and then fades. Desensitization is why people cycle it. Cardiac literature is not a DIY heart protocol. It is not the clean GHRP.
Interactions & Contraindications
Cortisol and prolactin. Tachyphylaxis. Prolactinoma-class caution. Active cancer is a hard no.
Synergies & Common Stacks
Largest GHRH+GHRP pulse folklore, fastest receptor fade. Short cycles, not a heart-repair stack.
Frequently Asked Questions
Why does Hexarelin cause desensitization?▼
What is the Hexarelin dose?▼
References
- Deghenghi et al. “"Hexarelin, a new GH-releasing peptide".” Life Sciences (1994). PMID: 8164528
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