Anti-Aging

Humanin-HNG

S14G-humanin · HNG · Gly14-humanin

S14G substitution on humanin (HNG) — a more potent analog of the mitochondrial 24-aa peptide we already list. Used in cell and animal neuroprotection papers. Potency in a dish is not a human dose table. Not FDA-approved.

Not FDA-approved — research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Strong preclinical1 peer-reviewed citation
Typical research dose
Research; parent humanin community range 1-5 mg is not an HNG label
Frequency
1× daily (research)
Half-life
Short (parent ~30 min)
Common vials
5 mg
CAS
N/A
Molecular weight
~2.7 kDa class (24-aa analog)
Dose it
5 mg + 2 mL BAC water → 2.5 mg/mL · 500 mcg ≈ 20 units (U-100)
Open in calculator

Mechanism of Action

HNG is humanin with serine-14 replaced by glycine. In published models that substitution increases potency versus native humanin. Parent humanin is a 24-aa mitochondrial ORF peptide (PMID 11555613).

Potency in a dish is not a milligram conversion table. Do not treat HNG as “humanin but you use less” unless a paper says so for that exact endpoint.

Source: Humanin PMID: 11555613; HNG analog literature (S14G)

Dosing Protocol

Typical DoseResearch; parent humanin community range 1-5 mg is not an HNG label
Frequency1× daily (research)
Half-LifeShort (parent humanin ~30 min; HNG potency ≠ longer t½)
Common Vial Sizes5 mg

Dosing Protocols

Human

Dose
None established
Frequency
n/a
Note: Parent community mg ranges are already unlabeled. HNG is not automatically a lower milligram.

Administration

Route
SC research (vendor)
Timing
Not established.
Fasting Required?
No — food timing not critical

Expected Timeline

Models
Neuroprotection papers — not a consumer timeline.

Who Is It For?

MDP analog identity

Low

We list native humanin separately. This is the S14G SKU.

Reconstitution Example

Vial
5 mg
Diluent
2 mL
Concentration
2.5 mg/mL
Per Unit (100u syringe)
25 mcg
Dose of 500 mcg = 20 units on a 100-unit insulin syringe
🧮 Calculate Your Exact Humanin-HNG Dose →

Safety & Considerations

Research analog. Mitochondrial peptides are not gentle longevity vitamins. No approved indication.

Regulatory & Legal Status

FDA Status (US)
Research Only

S14G humanin analog. Not an approved MDP drug

WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Humanin-HNG vs. Humanin

AttributeHumanin-HNGHumanin
SequenceS14G substitution (HNG)Native 24-aa MDP
Potency (models)Higher in published cell/animal workParent MDP
Human doseNot establishedNot established (community mg ranges exist)

Verdict: HNG is a point mutant, not a new gene. Do not copy humanin milligram folklore onto HNG without a citation.

Dosing Quick Reference

Humanin-HNG— Dosing Guide
Dose Range
Research; parent humanin community range 1-5 mg is not an HNG label
Half-Life
Short (parent humanin ~30 min; HNG potency ≠ longer t½)
Frequency
1× daily (research)
Route
Subcutaneous
5 mg vial
💧 2 mL BAC water📐 2.5 mg/mL💉 25 mcg/unit (100u syringe)
Anti-Agingcalcmypeptide.com

Frequently Asked Questions

Is HNG just stronger humanin?▼
In some models, S14G is more potent. That is not a human dose chart and not a longer half-life by default.

References

  1. Hashimoto Y et al. “Humanin, a novel peptide against Alzheimer disease-relevant insults.” PNAS / related (2001). PMID: 11555613

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