CalcMyPeptide
Hormone SupportAlso known as: KP-10, Metastin 45-54, KISS1 peptide

Kisspeptin-10

Kisspeptin-10 is the ultimate upstream master-switch of human reproduction and endocrine fertility. Operating as the absolute starting point of the Hypothalamic-Pituitary-Gonadal (HPG) axis, it is the exact neuropeptide that natively triggers the onset of puberty. It is aggressively utilized in cutting-edge fertility medicine to restart crashed endocrine systems and safely trigger egg maturation in IVF without hyper-stimulating the ovaries.

Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Moderate1 peer-reviewed citation

Quick Stats

Half-Life~4-6 minutes (IV); longer SC
Dose Range0.3-1 nmol/kg IV bolus (research)
FrequencyResearch protocol (IV infusion)
Vial Sizes1 mg
Bioavailability~100% (SC/IV)
Year Developed1999

Scientific Data

Molecular Formula
C63H83N15O13
Molecular Weight
1302.43 g/mol
CAS Number
374683-17-7
PubChem ID
11977616
Developer
Discovered by Lee et al., Millennium Pharmaceuticals (1999)

Mechanism of Action

Kisspeptin-10 (Kp-10) is a 10-amino-acid C-terminal fragment of kisspeptin-54, derived from the KISS1 gene product. It is a potent activator of the GnRH (gonadotropin-releasing hormone) pulse generator via the kisspeptin-1 receptor (KISS1R / GPR54) in the hypothalamus. Kp-10 stimulates LH and FSH surges, triggering downstream testosterone/estradiol production. It plays a critical role in puberty onset, reproductive axis regulation, and glucose homeostasis. Research applications include pulsatile GnRH secretion restoration in hypogonadotropic hypogonadism, fertility induction, and as an anti-obesity signal.

Source: PMID: 15713786

Dosing Protocol

Typical Dose0.3-1 nmol/kg IV bolus (research)
FrequencyResearch protocol (IV infusion)
Half-Life~3.6 minutes
Common Vial Sizes1 mg

Dosing Protocols

Fertility / HH Research

Dose
0.05 - 0.32 nmol/kg/pulse
Frequency
Pulsatile IV or SC (every 90 min in some protocols)
Note: Pulsatile delivery is critical — continuous infusion causes receptor desensitisation.

Body-Weight Dosing Reference

Estimated doses extrapolated from the published research range of 50–200 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.

WeightLowTargetHigh
120 lb(54 kg)39 mcg96 mcg154 mcg
140 lb(63 kg)45 mcg113 mcg180 mcg
160 lb(73 kg)52 mcg130 mcg209 mcg
180 lb(82 kg)59 mcg146 mcg234 mcg
200 lb(91 kg)65 mcg163 mcg260 mcg
220 lb(100 kg)71 mcg179 mcg286 mcg
250 lb(113 kg)81 mcg202 mcg323 mcg

💉 For exact syringe units based on your vial concentration, use the Kisspeptin-10 Reconstitution Calculator →

Administration

Route
Subcutaneous or IV (research)
Timing
Pulsatile protocols only. Nurse- or pump-administered in clinical trials.
Fasting Required?
No — food timing not critical

Expected Timeline

Minutes (IV)
Rapid LH surge within 15-30 minutes of Kp-10 bolus administration.
Days-Weeks (pulsatile)
Restoration of LH pulsatility and ovulation/testosterone restoration in hypogonadotropic patients.

Who Is It For?

Hypogonadotropic Hypogonadism

High

Triggers GnRH pulsatility and downstream HPG axis activation. Human trial evidence.

Fertility Induction

Moderate

Used in fertility protocols to stimulate ovulation without stimulating ovarian hyperstimulation.

Reconstitution Example

Vial
1 mg
Water
1 mL
Concentration
1 mg/mL
Per Unit (100u syringe)
10 mcg
Dose of 50 mcg = 5 units on a 100-unit insulin syringe
🧮 Calculate Your Exact Kisspeptin-10 Dose →

Safety & Considerations

Research peptide. Not FDA-approved. Ovarian hyperstimulation is a risk in fertility use. Continuous (non-pulsatile) administration causes receptor downregulation. Use only under specialist supervision.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Dosing Quick Reference

Kisspeptin-10— Dosing Guide
Dose Range
0.3-1 nmol/kg IV bolus (research)
Half-Life
~3.6 minutes
Frequency
Research protocol (IV infusion)
Route
Subcutaneous
1 mg vial
💧 1 mL BAC water📐 1 mg/mL concentration💉 10 mcg/unit (100u syringe)
Hormone Supportcalcmypeptide.com

Frequently Asked Questions

Why is pulsatile dosing important for kisspeptin-10?▼
Continuous kisspeptin-10 infusion downregulates KISS1R receptors and paradoxically suppresses the HPG axis. Pulsatile administration (mimicking physiological GnRH pulses every 60-90 min) maintains receptor sensitivity and LH stimulation.
Can kisspeptin-10 replace gonadorelin (GnRH) in protocols?▼
Not directly — kisspeptin-10 acts upstream of GnRH (stimulating GnRH release) while gonadorelin IS synthetic GnRH. Both are used for HPG axis stimulation, but via different mechanisms.

References

  1. Dhillo WS et al. “"Kisspeptin-10 restores LH pulsatility in male hypogonadotropic hypogonadism".” Journal of Clinical Endocrinology & Metabolism (2007). PMID: 17565032

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