Hormone Support

Kisspeptin-10

KP-10 · Metastin 45-54 · KISS1 peptide

Kisspeptin-10 is the ultimate upstream master-switch of human reproduction and endocrine fertility. Operating as the absolute starting point of the Hypothalamic-Pituitary-Gonadal (HPG) axis, it is the exact neuropeptide that natively triggers the onset of puberty. It is aggressively utilized in cutting-edge fertility medicine to restart crashed endocrine systems and safely trigger egg maturation in IVF without hyper-stimulating the ovaries.

Not FDA-approved - research chemical

Reviewed by CalcMyPeptide Editorial Team

·Last updated: August 2026·Evidence: Moderate·1 peer-reviewed citation

Typical research dose

0.3-1 nmol/kg IV bolus (research)

Frequency

Research protocol (IV infusion)

Half-life

~4-6 minutes (IV); longer SC

Common vials

1 mg

CAS

374683-17-7

Molecular weight

1302.43 g/mol

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Sexual / hormonal4.5/10
Shorter fragment used in human challenge tests. Not the 54-mer. Not a TRT alternative.

Compound card

Class: Kisspeptin-10 fragment (not kisspeptin-54)
Formula: C63H83N15O13
Status: Not FDA-approved · research use

Dose it

1 mg + 1 mL BAC water → 1 mg/mL · 50 mcg ≈ 5 units (U-100)

Open in calculator

How it works

Kisspeptin-10 (Kp-10) is a 10-amino-acid C-terminal fragment of kisspeptin-54, derived from the KISS1 gene product. It is a potent activator of the GnRH (gonadotropin-releasing hormone) pulse generator via the kisspeptin-1 receptor (KISS1R / GPR54) in the hypothalamus. Kp-10 stimulates LH and FSH surges, triggering downstream testosterone/estradiol production. It plays a critical role in puberty onset, reproductive axis regulation, and glucose homeostasis. Research applications include pulsatile GnRH secretion restoration in hypogonadotropic hypogonadism, fertility induction, and as an anti-obesity signal.

Source: PMID: 15713786

Research Use Cases

✓Hypogonadotropic Hypogonadism: High
✓Fertility Induction: Moderate

Dosing

Phase	Dose	Frequency	Notes
Fertility / HH Research	0.05 - 0.32 nmol/kg/pulse	Pulsatile IV or SC (every 90 min in some protocols)	Pulsatile delivery is critical - continuous infusion causes receptor desensitisation.

Administration

Route / form

Subcutaneous or IV (research)

Timing

Pulsatile protocols only. Nurse- or pump-administered in clinical trials.

Empty stomach?

No - Food timing is not critical.

Timeline

Minutes (IV)

Rapid LH surge within 15-30 minutes of Kp-10 bolus administration.

Days-Weeks (pulsatile)

Restoration of LH pulsatility and ovulation/testosterone restoration in hypogonadotropic patients.

Who it is for

Hypogonadotropic Hypogonadism

High

Triggers GnRH pulsatility and downstream HPG axis activation. Human trial evidence.

Fertility Induction

Moderate

Used in fertility protocols to stimulate ovulation without stimulating ovarian hyperstimulation.

Reconstitution

Vial	Water	Concentration	Example dose
1 mg lyophilized	1 mL BAC	1 mg/mL	Fragment math. Confirm the COA length.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research peptide. Not FDA-approved. Ovarian hyperstimulation is a risk in fertility use. Continuous (non-pulsatile) administration causes receptor downregulation. Use only under specialist supervision.

Regulatory & Legal Status

FDA Status (US)

Research Only

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

Different potency/PK from kisspeptin-54.

Verdict

Kisspeptin-10 is a fragment used in endocrine challenge work. Not the parent 54-mer and not a bedroom peptide.

Interactions & Contraindications

Frequently Asked Questions

Why is pulsatile dosing important for kisspeptin-10?▼

Continuous kisspeptin-10 infusion downregulates KISS1R receptors and paradoxically suppresses the HPG axis. Pulsatile administration (mimicking physiological GnRH pulses every 60-90 min) maintains receptor sensitivity and LH stimulation.

Can kisspeptin-10 replace gonadorelin (GnRH) in protocols?▼

Not directly - kisspeptin-10 acts upstream of GnRH (stimulating GnRH release) while gonadorelin IS synthetic GnRH. Both are used for HPG axis stimulation, but via different mechanisms.

References

Dhillo WS et al. “"Kisspeptin-10 restores LH pulsatility in male hypogonadotropic hypogonadism".” Journal of Clinical Endocrinology & Metabolism (2007). PMID: 17565032

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