Cosmetic Peptide

Leuphasyl

Pentapeptide-18 · Tyr-D-Ala-Gly-Phe-Leu

Pentapeptide-18, an enkephalin-related expression-line peptide sold next to Argireline and SNAP-8. Topical cosmetic, not a reconstitution job. We list it so the library matches the catalog people actually search.

Not FDA-approved — research chemical

Reviewed by CalcMyPeptide Editorial Team

·Last updated: April 2026·Evidence: Low

Typical research dose

Topical 3–10% solutions (INCI cosmetic use)

Frequency

1-2× daily topical

Half-life

Topical cosmetic

Common vials

N/A (oral)

CAS

N/A (cosmetic ingredient)

Mechanism of Action

Leuphasyl is INCI pentapeptide-18, an enkephalin-related expression-line peptide. It sits on the same cosmetic shelf as Argireline (SNAP-25 decoy) and SYN-AKE (waglerin analog). Different sequence, same job-to-be-done: topical expression lines.

No reconstitution calculator — typicalDose is topical percent, not mcg in a syringe.

Source: INCI pentapeptide-18 / Lipotec cosmetic literature (not a drug label)

Dosing Protocol

Typical Dose	Topical 3–10% solutions (INCI cosmetic use)
Frequency	1-2× daily topical
Half-Life	Topical cosmetic (not a systemic PK story)

Dosing Protocols

Topical cosmetic

Dose

3–10% in finished formulas (typical INCI use)

Frequency

1–2× daily

Note: Not injectable.

Administration

Route

Topical only on this page

Timing

AM/PM skincare.

Fasting Required?

No — food timing not critical

Expected Timeline

Weeks (cosmetic)

Expression-line marketing. Not botulinum toxin.

Who Is It For?

Cosmetic catalog completeness

Low

Listed next to Argireline/SNAP-8 so search matches the shelf.

Safety & Considerations

Cosmetic ingredient. Not injectable. Not a drug. Patch-test finished formulas.

Regulatory & Legal Status

FDA Status (US)

Research Only

Cosmetic pentapeptide-18. Not a drug

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Leuphasyl vs. Argireline

Attribute	Leuphasyl	Argireline
INCI	Pentapeptide-18	Acetyl hexapeptide-8
Claimed mechanism	Enkephalin-like expression-line peptide	SNAP-25 / SNARE decoy
Calculator	Topical — no recon math	Topical — no recon math

Verdict: Same shelf, different sequences. Neither is injectable botulinum toxin.

Dosing Quick Reference

Leuphasyl— Dosing Guide

Dose Range

Topical 3–10% solutions (INCI cosmetic use)

Half-Life

Topical cosmetic (not a systemic PK story)

Frequency

1-2× daily topical

Route

Oral

Cosmetic Peptidecalcmypeptide.com

Frequently Asked Questions

Can I inject Leuphasyl?▼

This leaf is topical cosmetic. Do not treat INCI percents as syringe mcg.

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