Cognitive & Nootropic

PE-22-28

PE22-28 · spadin analog PE-22-28 · TREK-1 peptide

Synthetic peptide fragment related to the TREK-1 / spadin antidepressant research line (PE-22-28). Research-chem SKU. Not an FDA antidepressant. Not Semax.

Not FDA-approved - research chemical

Reviewed by CalcMyPeptide Editorial Team

·Last updated: September 2026·Evidence: Low

Typical research dose

Research - no established human dose

Frequency

Not established

Half-life

Not established in humans

Common vials

5 mg

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Cognition2.5/10
Mechanism-band antidepressant peptide research. No adequate human efficacy program for the research SKU. Ceiling after haircut: 2.5.

Compound card

Sequence: TREK-1 / spadin-line research fragment (PE-22-28)
Class: Research neuropeptide (TREK-1 modulator line; not an FDA antidepressant)
Formula: Synthetic TREK-1-line peptide fragment
Status: Not FDA-approved · research use

Dose it

5 mg + 2 mL BAC water → 2.5 mg/mL · 100 mcg ≈ 4 units (U-100)

Open in calculator

How it works

PE-22-28 is a synthetic peptide in the TREK-1 / spadin antidepressant research lineage. Preclinical work frames TREK-1 potassium-channel modulation as a depression-biology target. That is not a US antidepressant NDA and not Semax.

Source: TREK-1 / spadin peptide literature (PE-22-28 analogs); no US NDA

Research Use Cases

✓Catalog identity: Low
✓Clinical depression care: Low

Dosing

Phase	Dose	Frequency	Notes
Human	None established	n/a	Do not invent a mg chart from forum posts.
Research identity	COA-dependent	Not established	If you have a vial, identity math only — not a protocol.

Administration

Route / form

Research SC (vendor) — not a labeled route

Timing

Not established

Empty stomach?

No - Food timing is not critical.

Timeline

Preclinical

Depression-model endpoints in papers. Not a week-1 human schedule.

Who it is for

Catalog identity

Low

Listed because people search TREK-1 peptides. Not an endorsement.

Clinical depression care

Low

Wrong tool. See a clinician for mood disorders.

Reconstitution

Vial	Water	Concentration	Example dose
5 mg lyophilized (if that is the SKU)	2.0 mL BAC	2.5 mg/mL	Identity math only. No established human dose.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research neuropeptide. Unknown purity on gray-market vials. Mood-active mechanisms are not casual biohacking. Not for pregnancy.

Regulatory & Legal Status

FDA Status (US)

Research Only

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

No established human dose for research-chem PE-22-28.
Animal TREK-1 papers are not a DSM treatment protocol.
Not Semax, not Selank, not ketamine.
This site will not treat major depression from a peptide page.

Verdict

PE-22-28 is a TREK-1-line research peptide, not an FDA antidepressant and not Semax. No sourced human dose table on this leaf.

Interactions & Contraindications

Research neuropeptide. Unknown purity on gray-market vials. Mood-active mechanisms are not casual biohacking. Not for pregnancy.

Frequently Asked Questions

Is there a standard human dose?▼

No established human dose on this leaf. Animal papers are not a titration chart.

Is this an antidepressant drug?▼

Not an FDA antidepressant. Research lineage only.

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