Clinical / Pharmaceutical

PNC-27

PNC27 · p53 12-26-MRP

A p53-derived peptide (residues 12–26 fused to a membrane-residency sequence) that kills some cancer cell lines in vitro by binding membrane HDM-2 and forming pores (PMID 20080680). It is not FDA-approved, not a cancer treatment, and has no Phase 3 program. Gray-market vials exist anyway — this leaf is identity, mechanism, and reconstitution math plus a hard “do not self-treat cancer” line.

Not FDA-approved — research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Low2 peer-reviewed citations
Typical research dose
No established human dose — preclinical / cell-line research only
Frequency
Not established
Half-life
Not established in humans
Common vials
5 mg
CAS
N/A
Molecular weight
~3 kDa class (construct)
Dose it
5 mg + 2 mL BAC water → 2.5 mg/mL · 500 mcg ≈ 20 units (U-100)
Open in calculator

Mechanism of Action

PNC-27 is p53 residues 12–26 fused to a membrane-residency peptide. In cell lines it binds membrane HDM-2 on some transformed cells and forms pores, causing necrosis independent of nuclear p53 (PMID 20080680). Mouse xenograft work exists. There is no approved indication, no Phase 3, and no established human dose.

Gray-market vials are not a cancer protocol. This page is identity, citation, and reconstitution arithmetic — plus a refusal to dress it up as treatment.

Source: PMID: 20080680 (PNAS 2010); PMID: 25117093

Not a cancer treatment

PNC-27 is preclinical. Buying a research vial is not oncology. Do not delay standard care. We will not print a “cycle” as if this were BPC-157.

Dosing Protocol

Typical DoseNo established human dose — preclinical / cell-line research only
FrequencyNot established
Half-LifeNot established in humans
Common Vial Sizes5 mg

Dosing Protocols

Human

Dose
None established
Frequency
n/a
Note: Calculator defaults are vial math only. They are not a protocol.

Administration

Route
Not established for humans
Timing
Not established.
Fasting Required?
No — food timing not critical

Expected Timeline

Cell culture
Rapid necrosis in susceptible lines in published papers — not a patient timeline.

Who Is It For?

Oncology research identity

Low

Legitimate papers, illegitimate consumer use. Listed so the library is honest about what the SKU is.

Reconstitution Example

Vial
5 mg
Diluent
2 mL
Concentration
2.5 mg/mL
Per Unit (100u syringe)
25 mcg
Dose of 500 mcg = 20 units on a 100-unit insulin syringe
🧮 Calculate Your Exact PNC-27 Dose →

Safety & Considerations

No human safety database sufficient for self-administration. Pore-forming peptides are not “gentle recovery compounds.” Not FDA-approved. Not a substitute for oncology care.

Regulatory & Legal Status

FDA Status (US)
Research Only

Preclinical oncology peptide. Not a cancer treatment. No FDA approval or Phase 3 program

WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Dosing Quick Reference

PNC-27— Dosing Guide
Dose Range
No established human dose — preclinical / cell-line research only
Half-Life
Not established in humans
Frequency
Not established
Route
Subcutaneous
5 mg vial
💧 2 mL BAC water📐 2.5 mg/mL💉 25 mcg/unit (100u syringe)
Clinical / Pharmaceuticalcalcmypeptide.com

Frequently Asked Questions

Is PNC-27 FDA-approved for cancer?▼
No. Preclinical construct. Approval status is research-only.
Why is it in a reconstitution library?▼
Because it is sold as a lyophilized vial and people search the name. Math without a protocol is still math. We will not invent doses.

References

  1. Sarafraz-Yazdi E et al. “PNC-27 binds membrane HDM-2 and kills cancer cells.” PNAS (2010). PMID: 20080680
  2. Davitt K et al. “PNC-27 in a p53-null leukemia line.” Ann Clin Lab Sci (2014). PMID: 25117093

Looking for a trusted source? See our recommended suppliers →

Independently tested · COA-verified · Save 10% with our exclusive code

← Back to Peptide Library