Cosmetic Peptide

PTD-DBM

CXXC5-blocking peptide · PTD-DBM hair peptide · Dishevelled-binding motif peptide

Protein-transduction-domain + Dishevelled-binding motif peptide that competes with CXXC5 for Dvl, intended to lift a brake on Wnt/β-catenin in hair-follicle models. Foundational paper is mouse + dermal papilla cells (PMID 28595998). No completed human efficacy trial. Not minoxidil, not finasteride, not a prescription hair drug.

Not FDA-approved — research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Strong preclinical1 peer-reviewed citation
Typical research dose
Topical / microneedle research solutions (vendor); no established human dose
Frequency
Topical per vendor protocol
Half-life
Not established in humans
Common vials
5 mg / 10 mg
CAS
N/A
Dose it
5 mg + 2 mL BAC water → 2.5 mg/mL · 500 mcg ≈ 20 units (U-100)
Open in calculator

Mechanism of Action

PTD-DBM is a cell-penetrating tag plus a Dishevelled-binding motif that competes with CXXC5 for Dvl, lifting a negative-feedback brake on Wnt/β-catenin in hair-follicle models. Lee et al. (J Invest Dermatol 2017, PMID 28595998) showed hair regrowth and wound-induced neogenesis in mice.

No completed human efficacy trial. Not minoxidil, not finasteride, not dutasteride. Microneedle + topical research use is vendor practice on top of a mouse paper.

Source: PMID: 28595998 (J Invest Dermatol 2017)

Mouse paper, not a hair drug

PMID 28595998 is real. A consumer vial is not that experiment. Do not delay standard AGA care.

Dosing Protocol

Typical DoseTopical / microneedle research solutions (vendor); no established human dose
FrequencyTopical per vendor protocol
Half-LifeNot established in humans (topical mouse work)
Common Vial Sizes5 mg, 10 mg

Dosing Protocols

Human

Dose
None established
Frequency
n/a
Note: Calculator defaults are vial math for people who still reconstitute a powder. Not a protocol.

Administration

Route
Topical / microneedle in published mouse work and vendor SKUs
Timing
Not established in humans.
Fasting Required?
No — food timing not critical

Expected Timeline

Mouse study
Regrowth / WIHN in the 2017 paper — not a patient timeline.

Who Is It For?

Hair-catalog identity

Low

Listed because The Peptide Catalog and others sell it. Evidence is preclinical.

Reconstitution Example

Vial
5 mg
Diluent
2 mL
Concentration
2.5 mg/mL
Per Unit (100u syringe)
25 mcg
Dose of 500 mcg = 20 units on a 100-unit insulin syringe
🧮 Calculate Your Exact PTD-DBM Dose →

Safety & Considerations

Wnt pathway tools are not gentle cosmetics by default. No human safety database for self-microneedling this peptide. Not a substitute for dermatologic AGA care.

Regulatory & Legal Status

FDA Status (US)
Research Only

Preclinical hair-follicle peptide (PMID 28595998). No human efficacy trial

WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

PTD-DBM vs. AHK-Cu

AttributePTD-DBMAHK-Cu
JobCXXC5–Dvl competitor (Wnt)Copper tripeptide (hair/cosmetic)
EvidenceMouse + cell (PMID 28595998)Cosmetic / in vitro copper-peptide
Human trialsNone completedNone as a hair drug

Verdict: Both are hair-catalog peptides. PTD-DBM is a Wnt-pathway tool peptide. AHK-Cu is a copper tripeptide. Neither replaces minoxidil.

Dosing Quick Reference

PTD-DBM— Dosing Guide
Dose Range
Topical / microneedle research solutions (vendor); no established human dose
Half-Life
Not established in humans (topical mouse work)
Frequency
Topical per vendor protocol
Route
Subcutaneous
5 mg vial10 mg vial
💧 2 mL BAC water📐 2.5 mg/mL💉 25 mcg/unit (100u syringe)
Cosmetic Peptidecalcmypeptide.com

Frequently Asked Questions

Does PTD-DBM regrow hair in humans?▼
There is no completed peer-reviewed human efficacy trial. The flagship paper is mouse + cell (PMID 28595998).
Do I inject it?▼
The literature is topical on mouse skin. Vendor injectable SKUs are not that experiment.

References

  1. Lee SH et al. “Targeting of CXXC5 by a competing peptide stimulates hair regrowth.” J Invest Dermatol (2017). PMID: 28595998

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