Mitochondrial

SHLP2

Small humanin-like peptide 2 · SHLP-2

Small humanin-like peptide 2 — another mitochondrial ORF peptide in the same family as humanin (which we list). Characterized in Cobb et al. 2016 as an MDP with metabolic/cell-survival signals distinct from humanin. Research SKU. Not a second humanin, not MOTS-c.

Not FDA-approved — research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Low1 peer-reviewed citation
Typical research dose
Research; no established human dose
Frequency
Not established
Half-life
Unknown (SKU unpublished)
Common vials
5 mg
CAS
N/A
Dose it
5 mg + 2 mL BAC water → 2.5 mg/mL · 500 mcg ≈ 20 units (U-100)
Open in calculator

Mechanism of Action

SHLP2 is a small humanin-like peptide encoded as a mitochondrial ORF, characterized with other SHLPs in Cobb et al. 2016 (PMID 26718411). It is not humanin, not MOTS-c, not SS-31.

Isoform-specific cell effects in that paper are why we keep a separate ID instead of aliasing it onto humanin.

Source: PMID: 26718411 (Cobb / Cohen MDP paper)

Dosing Protocol

Typical DoseResearch; no established human dose
FrequencyNot established
Half-LifeUnknown (MDP class; SKU PK unpublished)
Common Vial Sizes5 mg

Dosing Protocols

Human

Dose
None established
Frequency
n/a
Note: Do not copy humanin milligrams onto SHLP2.

Administration

Route
Research SC (vendor)
Timing
Not established.
Fasting Required?
No — food timing not critical

Expected Timeline

Cell / MDP papers
Not a consumer longevity curve.

Who Is It For?

MDP identity

Low

Sibling to humanin in the catalog sense. Different ORF peptide.

Reconstitution Example

Vial
5 mg
Diluent
2 mL
Concentration
2.5 mg/mL
Per Unit (100u syringe)
25 mcg
Dose of 500 mcg = 20 units on a 100-unit insulin syringe
🧮 Calculate Your Exact SHLP2 Dose →

Safety & Considerations

Research MDP. No approved indication. Unknown SKU identity on gray-market vials.

Regulatory & Legal Status

FDA Status (US)
Research Only

Mitochondrial ORF peptide (humanin-like). No FDA program

WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

SHLP2 vs. Humanin

AttributeSHLP2Humanin
IdentitySmall humanin-like peptide 2Humanin (24-aa MDP)
PaperCobb et al. 2016 (PMID 26718411)Hashimoto / MDP discovery trail
Dose transferDo not copy humanin mg onto SHLP2Community ranges are already unlabeled

Verdict: Same mitochondrial neighborhood, different ORF peptide. SHLP2 is not a humanin nickname.

Dosing Quick Reference

SHLP2— Dosing Guide
Dose Range
Research; no established human dose
Half-Life
Unknown (MDP class; SKU PK unpublished)
Frequency
Not established
Route
Subcutaneous
5 mg vial
💧 2 mL BAC water📐 2.5 mg/mL💉 25 mcg/unit (100u syringe)
Mitochondrialcalcmypeptide.com

Frequently Asked Questions

Is SHLP2 a type of humanin?▼
It is a related mitochondrial ORF peptide, not a humanin truncation. Separate sequence, separate ID.

References

  1. Cobb LJ et al. “Naturally occurring mitochondrial-derived peptides (SHLPs).” Aging (2016). PMID: 26718411

Looking for a trusted source? See our recommended suppliers →

Independently tested · COA-verified · Save 10% with our exclusive code

← Back to Peptide Library