Cosmetic Peptide

SYN-AKE

Tripeptide-3 · Dipeptide diaminobutyroyl benzylamide diacetate · Waglerin-1 analog

Waglerin-1-inspired tripeptide (DSM/Pentapharm SYN-AKE) for expression lines. Topical cosmetic next to Argireline/SNAP-8/Leuphasyl. Not snake venom, not a neuromuscular drug, not injectable Botox.

Not FDA-approved — research chemical

Reviewed by CalcMyPeptide Editorial Team

·Last updated: April 2026·Evidence: Low

Typical research dose

Topical 1–4% solutions (INCI cosmetic use)

Frequency

1-2× daily topical

Half-life

Topical cosmetic

Common vials

N/A (oral)

Mechanism of Action

SYN-AKE is a waglerin-1-inspired tripeptide (DSM/Pentapharm) used in topical expression-line formulas. The claimed mechanism is nicotinic-receptor antagonism in a cosmetic model. It is not snake venom, not botulinum toxin, and not Argireline’s SNARE decoy.

Source: Pentapharm / DSM SYN-AKE technical literature

Dosing Protocol

Typical Dose	Topical 1–4% solutions (INCI cosmetic use)
Frequency	1-2× daily topical
Half-Life	Topical cosmetic (not a systemic PK story)

Dosing Protocols

Topical cosmetic

Dose

1–4% in finished formulas (typical)

Frequency

1–2× daily

Note: Not injectable.

Administration

Route

Topical only on this page

Timing

AM/PM skincare.

Fasting Required?

No — food timing not critical

Expected Timeline

Weeks (cosmetic)

Expression-line marketing.

Who Is It For?

Cosmetic catalog completeness

Low

Shelf-mate of Argireline, SNAP-8, Leuphasyl.

Safety & Considerations

Cosmetic ingredient. Not venom. Not a neuromuscular drug. Patch-test finished formulas.

Regulatory & Legal Status

FDA Status (US)

Research Only

Cosmetic waglerin analog (tripeptide-3). Not a neuromuscular drug

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

SYN-AKE vs. Argireline

Attribute	SYN-AKE	Argireline
Inspiration	Waglerin-1 (nAChR cosmetic analog)	SNAP-25 SNARE decoy
INCI	Tripeptide-3 / dipeptide diaminobutyroyl benzylamide diacetate	Acetyl hexapeptide-8
Use	Topical expression lines	Topical expression lines

Verdict: SYN-AKE is not Argireline and not venom. Cosmetic peptides, topical only on this site.

Dosing Quick Reference

SYN-AKE— Dosing Guide

Dose Range

Topical 1–4% solutions (INCI cosmetic use)

Half-Life

Topical cosmetic (not a systemic PK story)

Frequency

1-2× daily topical

Route

Oral

Cosmetic Peptidecalcmypeptide.com

Frequently Asked Questions

Is SYN-AKE snake venom?▼

No. It is a synthetic analog inspired by waglerin-1, used topically in cosmetics.

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