Immune & Thymic

Thymopentin

TP-5 · thymopoietin pentapeptide · Arg-Lys-Asp-Val-Tyr

Synthetic pentapeptide (Arg-Lys-Asp-Val-Tyr) corresponding to thymopoietin residues 32–36 (TP-5). Historical immune-modulating research and some non-US clinical use. Not thymosin alpha-1. Not Thymalin. Not a US approved immune drug.

Not FDA-approved - research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: September 2026Evidence: Low
Typical research dose
Research / historical immune protocols - not a US NDA
Frequency
Historical schedules vary; not a labeled US course
Half-life
Minutes-class parent
Common vials
1 mg / 5 mg
CAS
69558-55-0
Molecular weight
~679.8 g/mol

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Longevity / aging2.5/10

    Historical immune-peptide file. Not thymosin α1’s modern evidence body. Community/mechanism after haircut: 2.5.

Compound card

Sequence
Arg-Lys-Asp-Val-Tyr (TP-5)
Class
Synthetic thymopoietin pentapeptide (historical immune research)
Formula
C30H49N9O9
Status
Not FDA-approved · research use
Dose it
1 mg + 1 mL BAC water → 1 mg/mL · 50 mcg ≈ 5 units (U-100)
Open in calculator

How it works

Thymopentin (TP-5) is the synthetic pentapeptide Arg-Lys-Asp-Val-Tyr corresponding to thymopoietin residues 32–36. Classical work framed T-cell differentiation signals. It is not thymosin alpha-1, not Thymalin, and not a US approved immune drug.

Source: Classical thymopoietin / TP-5 literature; confirm jurisdiction — not an FDA immune indication

Research Use Cases

  • ✓Immune peptide identity: Moderate
  • ✓US clinical immune care: Low

Dosing

PhaseDoseFrequencyNotes
Historical / researchHistorical parenteral bands varySchedule varies by old protocolsNot a labeled US course. Identity first.

Administration

Route / form
Historical parenteral research use
Timing
Not a modern labeled schedule
Empty stomach?
No - Food timing is not critical.

Timeline

Historical literature
Immune-marker stories in old papers — not a 2026 vaccine-adjuvant protocol.

Who it is for

Immune peptide identity

Moderate

Useful disambiguation vs TA1 / Thymalin.

US clinical immune care

Low

Wrong tool for diagnosed immunodeficiency.

Reconstitution

VialWaterConcentrationExample dose
1 mg lyophilized (example)1.0 mL BAC1 mg/mLIdentity math only. Confirm fill on COA.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research / historical immune peptide. Unknown purity on modern research SKUs. Not a substitute for vaccines, antivirals, or immunology clinic care.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • Not interchangeable with thymosin alpha-1 or Thymalin.
  • Minutes-class half-life shaped historical schedules — not a weekly GH chart.
  • No US approved immune indication on this leaf.
  • This site will not treat immunodeficiency from a TP-5 page.

Verdict

Thymopentin is TP-5, a thymopoietin fragment with a historical immune file. It is not thymosin alpha-1 and not a US immune NDA.

Interactions & Contraindications

Research / historical immune peptide. Unknown purity on modern research SKUs. Not a substitute for vaccines, antivirals, or immunology clinic care.

Appears in goal guides

Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.

Immune Resilience & Post-Viral Stack

Thymosin α1 and Thymalin identity. Zadaxin is not a US NDA. This is not a viral-pathogenesis or thymic-regeneration treatment page.

View Protocol →

Frequently Asked Questions

Is thymopentin the same as thymosin alpha-1?▼
No. Different sequences and evidence bodies. See the thymosin alpha-1 leaf.
Is it FDA-approved?▼
Not as a US immune drug on this leaf. Historical and non-US stories do not create an FDA NDA.

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