Mitochondrial

Urolithin A

UA · Mitopure · urolithin A

Gut-microbiome metabolite of ellagitannins that activates mitophagy signaling. Sold as an oral longevity ingredient (e.g. Mitopure-branded products). Not a peptide. Not MOTS-c. Not SS-31. Do not put it in the reconstitution calculator.

Not FDA-approved - research chemical

Reviewed by CalcMyPeptide Editorial Team

·Last updated: September 2026·Evidence: Moderate

Typical research dose

Oral supplement / researched doses - not a peptide vial

Frequency

Once daily oral (product-dependent)

Half-life

Oral metabolite PK (not a peptide t½)

Common vials

N/A (oral)

CAS

1143-70-0

Molecular weight

~228 Da

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Longevity / aging4/10
Human supplement studies on mitophagy/muscle biomarkers exist. Not a lifespan NDA. Not a peptide. Score 4.

Compound card

Sequence: Small-molecule ellagitannin metabolite (not a peptide)
Class: Oral mitophagy-support ingredient (urolithin A)
Formula: C13H8O4
Status: Not FDA-approved · research use

How it works

Urolithin A is a gut-microbiome metabolite of ellagitannins (pomegranate, walnuts, etc.) studied for mitophagy — clearance of damaged mitochondria. Brand products exist. It is not MOTS-c, not SS-31, and not a reconstitution peptide.

Source: Published urolithin A human supplement and mitophagy papers; brand products are not research peptides

Research Use Cases

✓Mitochondrial / mitophagy literacy: Moderate
✓Peptide reconstitution: Low

Dosing

Phase	Dose	Frequency	Notes
Oral products	Per studied supplement bands / product label	Once daily oral	Typically hundreds of mg in published supplement work. Follow the product you bought — this is not a vial.

Administration

Route / form

Oral

Timing

Daily with product instructions

Empty stomach?

No - Food timing is not critical.

Timeline

Weeks to months

Biomarker and muscle-function endpoints in supplement studies — not a peptide recovery curve.

Who it is for

Mitochondrial / mitophagy literacy

Moderate

Real human supplement literature. Still not a drug NDA.

Peptide reconstitution

Low

Wrong category.

Safety & Considerations

Oral ingredient. GI tolerance varies. Not a substitute for diagnosed mitochondrial disease care. Not injectable peptide PIP.

Regulatory & Legal Status

FDA Status (US)

Research Only

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

Not a peptide. No BAC-water chart.
Human studies are supplement/biomarker programs, not a longevity drug label.
Brand doses are product-label problems, not research-chem folklore on this leaf.
This site will not treat mitochondrial disease from a UA page.

Verdict

Urolithin A is an oral mitophagy metabolite ingredient, not a peptide. Do not put it in the reconstitution calculator. It is not MOTS-c or SS-31.

Interactions & Contraindications

Oral ingredient. GI tolerance varies. Not a substitute for diagnosed mitochondrial disease care. Not injectable peptide PIP.

Appears in goal guides

Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.

Anti-Aging & Cellular Longevity

Educational map of GH secretagogues, pineal cytogens, and dermal peptides used in longevity folklore. Telomerase and “youthful gene expression” are not a US anti-aging indication.

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