Comparison
MK-677 vs Ipamorelin
Side-by-side attributes from our library comparison data. Read each peptide leaf for dosing math, regulatory status, and citations.
MK-677 vs. Ipamorelin
| Attribute | MK-677 | Ipamorelin |
|---|---|---|
| Administration | Oral (daily capsule/liquid) | Subcutaneous injection (daily) |
| Mechanism | Ghrelin receptor agonist (oral GHRP) | Ghrelin receptor agonist (injectable GHRP) |
| GH/IGF-1 Elevation | Sustained 24-hr elevation | Pulsatile - lasts ~2 hrs post-injection |
| Appetite | Strong hunger stimulation | Minimal appetite stimulation |
| Water Retention | Notable - common early | Minimal |
| Sleep Quality | Strong improvement reported | Mild improvement |
Verdict: MK-677 offers the convenience of oral dosing with sustained 24-hour IGF-1 elevation but causes more hunger and water retention than Ipamorelin. Many users combine both for pulsatile + basal GH coverage.