CJC-1295 (no DAC)
Mod GRF(1-29) · Modified GRF · MOD-GRF (1-29) · CJC-1295 no DAC
Tetrasubstituted GHRH(1-29) / Mod GRF, not the albumin-binding DAC analog. Catalogs reuse the CJC name. Teichman 2006 is the DAC molecule. Stacking with ipamorelin is two receptors, not a labeled 2–5× GH claim.
Use-case scores
0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.
- Muscle / recomp4/10
Community GHRH pulse protocol. Do not steal Teichman DAC PK. Single-lab/community ceiling 4.
- Recovery & sleep3.5/10
Bedtime fasted shots are folklore plus GH physiology. Not a sleep RCT.
Compound card
- Sequence
- Tetrasubstituted GHRH(1-29) / Mod GRF (no albumin DAC)
- Class
- Short-acting GHRH analog (community “CJC no DAC”; not the DAC PK papers)
- Formula
- C130H220N42O35S
- Status
- Not FDA-approved · research use
How it works
CJC-1295 without DAC, also known as Modified GRF(1-29) or Mod GRF, is a truncated and modified analog of GHRH (amino acids 1-29). The four amino acid substitutions protect it from enzymatic degradation, extending the biological half-life from ~7 minutes (native GHRH) to approximately 30 minutes.
Unlike the DAC version, Mod GRF creates sharp, discrete GH pulses that closely mimic natural physiology. This is why it is commonly paired with a ghrelin mimetic (like Ipamorelin) - the GHRH analog amplifies the pulse amplitude while the GHRP initiates the pulse. Dual-receptor synergy is real GHRH+GHRP pharmacology. A “2–5× more GH” slogan is not a trial endpoint on this SKU.
Source: PMID: 16352683
Goal context
Pulsatile GH with a GHRP
Mod GRF creates sharp GH pulses (~30 min half-life). Clinics pair it with ipamorelin because GHRH and GHRP hit different receptors. Dual-receptor synergy is pharmacology, not a labeled 2–5× claim.
Not the DAC molecule
Teichman 2006 is CJC-1295 with DAC. This SKU is tetrasubstituted GRF(1-29). Catalogs reuse the CJC name — confirm the COA.
Background & History
This SKU is tetrasubstituted GRF(1-29) / Mod GRF, not the DAC analog. Catalogs reuse the CJC name. PMID 16352683 is the DAC paper. Pulse is minutes-class, which is why people stack a GHRP.
Research Use Cases
- ✓Mod GRF identity vs CJC-1295 with DAC
- ✓Why empty-stomach timing exists (insulin blunts a GH pulse)
- ✓Not a 2–5× GH stack slogan
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Standard (Solo) | 100 - 300 mcg | 1-3× daily | Inject on empty stomach. 1hr no food before, 30min after. |
| Stack with Ipamorelin | 100 mcg + 100 mcg Ipamorelin | 1-3× daily | Most popular GH secretagogue stack. Synergistic GHRH + GHRP effect. |
Administration
Timeline
Who it is for
GH Optimization (Stacked)
ModerateGHRH analog in a GHRP mix. Two receptors, not a labeled 2–5× claim.
Anti-Aging / Recovery
LowPulsatile GH is physiology. This SKU is not a somatopause NDA.
Reconstitution
| Vial | Water | Concentration | Example dose |
|---|---|---|---|
| 2 mg lyophilized | 2.0 mL BAC | 1 mg/mL | 100 mcg = 0.10 mL = 10 units on a U-100. |
Change vial size or water volume? Open the reconstitution calculator.
Safety & Considerations
Research peptide. May cause facial flushing immediately after injection (common and transient). Should not be used by individuals with active cancer. Best used on an empty stomach for maximum GH pulse amplitude.
Regulatory & Legal Status
Competitive athletes subject to anti-doping controls should not use CJC-1295 (no DAC).
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- PMID 18034534 is not this peptide. Prakash/Goa BioDrugs 1999 is sermorelin (PMID 18031173).
- This leaf previously copied the DAC CAS 863288-34-0. That CAS is the albumin-binding analog. Confirm the COA.
- PMID 16352683 on the catalog card is Teichman DAC. Do not paste it as Mod GRF PK.
Human evidence
Moderate · community pulse protocol (not Teichman DAC)
- PMID 18034534 is not this peptide. Prakash/Goa BioDrugs 1999 is sermorelin.
- PMID 16352683 (Teichman) is the DAC analog — do not paste it as Mod GRF PK.
Verdict
This SKU is tetrasubstituted GRF(1-29), not CJC-1295 with DAC. Catalogs reuse the CJC name. Teichman 2006 is the DAC molecule. Stacking with ipamorelin is pharmacology (two receptors), not a 2–5× labeled claim.
Interactions & Contraindications
Empty stomach for a pulse. Do not combine with the DAC analog as if they were different jobs you need both of. Glucocorticoids blunt GH response.
Synergies & Common Stacks
Two pituitary receptors. That is why clinics mix them. A printed 2–5× multiplier is marketing unless you cite doses and a paper.
CJC-1295 (no DAC) vs. CJC-1295 (DAC)
Canonical comparison: CJC-1295 (no DAC) vs CJC-1295 (DAC)
| Attribute | CJC-1295 (no DAC) | CJC-1295 (DAC) |
|---|---|---|
| GH Pattern | Pulsatile - natural-mimicking spikes | Sustained non-pulsatile GH bleed |
| Half-Life | ~30 minutes | 5.8–8.1 days |
| Dosing | 1–3× daily injection required | 1–2× weekly |
| Best Paired With | Ipamorelin (gold-standard stack) | Typically solo; optional GHRP addition |
| IGF-1 Profile | Physiological - pulsatile rises | Sustained elevation |
Verdict: CJC-1295 (No DAC) is the preferred form for users who want to replicate natural GH pulsatility and minimize sustained IGF-1 elevation. The tradeoff is more frequent injections vs. the DAC form.
Appears in goal guides
Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.
Anti-Aging & Cellular Longevity
Educational map of GH secretagogues, pineal cytogens, and dermal peptides used in longevity folklore. Telomerase and “youthful gene expression” are not a US anti-aging indication.
Hypertrophic Muscle & Recomposition
GHRH/GHRP stacks versus somatropin. Secretagogues pulse endogenous GH; they are not a hypertrophy NDA.
Ultimate Athletic Performance
Muscle and vascular cytomax plus BPC-157/TB-500 and GH secretagogues as they show up in athletic folklore. Injectable repair peptides are WADA-prohibited. This is not a doping pass.
Frequently Asked Questions
Why is CJC-1295 no DAC paired with Ipamorelin?▼
How should I time my CJC-1295 no DAC injections?▼
What dose of CJC-1295 no DAC should I use?▼
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