CJC-1295 (no DAC)
CJC-1295 without DAC—clinically classified as Modified GRF(1-29)—is a rapidly acting Growth Hormone Releasing Hormone analog that mimics the body’s natural physiological GH rhythm. Completely avoiding the continuous "GH bleed" associated with the DAC version, Mod GRF(1-29) delivers an intense, acute spike in Growth Hormone meant to closely mirror natural nocturnal pulses. In longevity and performance protocols, it is virtually always stacked with a GHRP (like Ipamorelin) to achieve a profoundly synergistic, non-suppressive GH release.
Quick Stats
Scientific Data
Mechanism of Action
CJC-1295 without DAC, also known as Modified GRF(1-29) or Mod GRF, is a truncated and modified analog of GHRH (amino acids 1-29). The four amino acid substitutions protect it from enzymatic degradation, extending the biological half-life from ~7 minutes (native GHRH) to approximately 30 minutes.
Unlike the DAC version, Mod GRF creates sharp, discrete GH pulses that closely mimic natural physiology. This is why it is commonly paired with a ghrelin mimetic (like Ipamorelin) — the GHRH analog amplifies the pulse amplitude while the GHRP initiates the pulse, creating a synergistic effect that exceeds either peptide alone.
Source: PMID: 16352683
Background & History
CJC-1295 without DAC, commercially known as Modified GRF(1-29) or Mod GRF, is derived from the natural 44-amino-acid GHRH by retaining only the bioactive first 29 amino acids with four protective substitutions (Ala2→D-Ala, Gln8→Ala, Ala15→Ala, Leu27→Ala). These substitutions protect against enzymatic degradation by dipeptidyl peptidase-4 while preserving full receptor binding affinity. First described in research by Sato et al., it remains the preferred GHRH analog for physiological pulsatile GH protocols.
Research Use Cases
- ✓Pulsatile GH release protocols mimicking natural physiology
- ✓Pre-sleep GH pulse maximization for recovery and anabolism
- ✓Stacked with GHRPs for synergistic GH release
- ✓Body recomposition in GH-deficient adults
Dosing Protocol
| Typical Dose | 100-300 mcg/injection |
| Frequency | 1-3× daily |
| Half-Life | ~30 minutes |
| Common Vial Sizes | 2 mg, 5 mg |
Dosing Protocols
Standard (Solo)
Stack with Ipamorelin
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 100–300 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 77 mcg | 154 mcg | 231 mcg |
| 140 lb(63 kg) | 90 mcg | 180 mcg | 270 mcg |
| 160 lb(73 kg) | 104 mcg | 209 mcg | 313 mcg |
| 180 lb(82 kg) | 117 mcg | 234 mcg | 351 mcg |
| 200 lb(91 kg) | 130 mcg | 260 mcg | 390 mcg |
| 220 lb(100 kg) | 143 mcg | 286 mcg | 429 mcg |
| 250 lb(113 kg) | 161 mcg | 323 mcg | 484 mcg |
💉 For exact syringe units based on your vial concentration, use the CJC-1295 (no DAC) Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
GH Optimization (Stacked)
HighBest used in the GHRH+GHRP combo with Ipamorelin for maximal, physiological GH pulses.
Anti-Aging / Recovery
ModerateNatural GH pulse preservation is favorable for long-term use vs. direct GH.
Reconstitution Example
Safety & Considerations
Research peptide. May cause facial flushing immediately after injection (common and transient). Should not be used by individuals with active cancer. Best used on an empty stomach for maximum GH pulse amplitude.
Regulatory & Legal Status
Competitive athletes subject to anti-doping controls should not use CJC-1295 (no DAC).
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Must be injected on an empty stomach — insulin blunts the GH pulse. Avoid combining with CJC-1295 DAC (redundant mechanisms). Glucocorticoids suppress GH response. Evening dosing maximizes natural GH rhythm synchronization.
Synergies & Common Stacks
The gold-standard GHRH+GHRP stack. Mod GRF amplifies pulse amplitude; Ipamorelin initiates the pulse cleanly without cortisol or prolactin elevation. Typically dosed 100 mcg + 100 mcg per injection.
More potent GH release than with Ipamorelin, at the cost of some cortisol and prolactin elevation. Good for anabolic-focused protocols.
Strongest hunger drive — used when caloric intake increase is desirable alongside GH elevation.
CJC-1295 (no DAC) vs. CJC-1295 (DAC)
| Attribute | CJC-1295 (no DAC) | CJC-1295 (DAC) |
|---|---|---|
| GH Pattern | Pulsatile — natural-mimicking spikes | Sustained non-pulsatile GH bleed |
| Half-Life | ~30 minutes | 5.8–8.1 days |
| Dosing | 1–3× daily injection required | 1–2× weekly |
| Best Paired With | Ipamorelin (gold-standard stack) | Typically solo; optional GHRP addition |
| IGF-1 Profile | Physiological — pulsatile rises | Sustained elevation |
Verdict: CJC-1295 (No DAC) is the preferred form for users who want to replicate natural GH pulsatility and minimize sustained IGF-1 elevation. The tradeoff is more frequent injections vs. the DAC form.
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Dosing Quick Reference
Frequently Asked Questions
Why is CJC-1295 no DAC paired with Ipamorelin?▼
How should I time my CJC-1295 no DAC injections?▼
What dose of CJC-1295 no DAC should I use?▼
References
- Prakash & Goa “"Growth hormone-releasing hormone and its analogs".” BioDrugs (1999). PMID: 18034534
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