DSIP
Delta Sleep-Inducing Peptide
Nine-residue peptide from 1970s delta-sleep literature. Minutes-class plasma t½. Not a hypnotic NDA, not a withdrawal protocol, not a cortisol-reset drug.
Use-case scores
0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.
- Recovery & sleep3/10
Graf-era human and animal sleep papers exist. Minutes-class half-life. Not a hypnotic NDA. Community/small-human: 3.
Compound card
- Sequence
- WAGGDASGE
- Class
- Delta-sleep-inducing nonapeptide
- Formula
- C35H48N10O15
- Status
- Not FDA-approved · research use
How it works
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide that promotes delta-wave (Stage 3/4 deep) sleep - the most restorative phase of the sleep cycle. It was first isolated from rabbit brain venous blood in 1974 at the University of Geneva.
DSIP modulates several neurochemical systems: it enhances serotonin release, reduces stress-related ACTH and cortisol levels, and normalizes circadian rhythms. Unlike sedative-hypnotics (benzodiazepines, z-drugs), DSIP promotes delta-wave architecture rather than artificially sedating, maintaining natural sleep stage progression.
Source: PMID: 6325741
Background & History
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood by Marcel Monnier at the University of Basel in 1977. It was the first peptide identified specifically for sleep regulation and produced normal physiological slow-wave sleep in animal and human experiments without the hangover effects of pharmacological sleep aids. Its mechanisms include modulation of serotonin, norepinephrine, and GABA systems, as well as normalization of cortisol circadian rhythms - making it useful beyond sleep into stress resilience.
Research Use Cases
- ✓Identity: 1970s nonapeptide vs a hypnotic NDA (there is not one)
- ✓Minutes-class t½ vs bedtime folklore
- ✓Not a withdrawal or insomnia protocol on this site
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Sleep Protocol | 200 - 500 mcg | SC injection 30-60 min before sleep, 5-10 days on / rest off | Shorter half-life requires careful timing. May require a cycle of several nights to establish delta-wave entrainment. |
Administration
Timeline
Who it is for
Deep Sleep / Insomnia
LowPromotes delta-wave sleep without sedation. Limited modern clinical trials but significant preclinical and historical research.
Cortisol / Stress Normalization
LowReduces ACTH and cortisol - may improve sleep quality in high-stress individuals.
Reconstitution
| Vial | Water | Concentration | Example dose |
|---|---|---|---|
| 5 mg lyophilized | 2.5 mL BAC | 2 mg/mL | 100 mcg on 5 mg / 2.5 mL (2 mg/mL) = 0.05 mL = 5 units on a U-100. |
Change vial size or water volume? Open the reconstitution calculator.
Safety & Considerations
Research peptide. Limited modern human safety data. Generally well-tolerated in older studies. May cause morning grogginess at higher doses. Not for use with CNS depressants.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- PMID 6325741 is historical, not a 2026 insomnia Phase 3.
- This site will not treat insomnia, PTSD, or withdrawal from a DSIP page.
Verdict
DSIP is a nine-residue peptide from the 1970s sleep literature. Plasma t½ is minutes. It is not Ambien, not a withdrawal protocol, and not a cortisol-reset drug.
Interactions & Contraindications
Additive sedative effects with benzodiazepines, z-drugs, or antihistamines - reduce doses of sleeping medications when using DSIP. Alcohol amplifies CNS depressant effects. May normalize cortisol rhythm - if using steroids/HRT, timing may be affected.
Synergies & Common Stacks
Daytime tuftsin analog vs nighttime DSIP folklore. Two SKUs is not a stress-sleep protocol and not a US insomnia NDA.
Epitalon restores melatonin production; DSIP induces slow-wave sleep. Together they address both melatonin quantity and sleep quality architecture.
Appears in goal guides
Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.
Frequently Asked Questions
How does DSIP differ from sleep drugs like Ambien?▼
What is the best time to inject DSIP?▼
References
- Schoenenberger GA, Monnier M “"Isolation and characterization of a sleep-inducing factor from rabbit brain".” PNAS (1977). PMID: 73474
- Schneider-Helmert D, Schoenenberger GA. “Delta sleep-inducing peptide (DSIP): an update.” Peptides (1983). PMID: 6318203
- Schneider-Helmert D. “Effect of DSIP on sleep disorders in depressive patients.” Eur Neurol (1984). PMID: 6430276
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