Selank
Selank is a precision-engineered heptapeptide analog of the natural immunomodulator Tuftsin, developed extensively by the Russian Institute of Molecular Genetics. Striking a flawless balance between profound anxiolysis (anxiety reduction) and severe mental clarity, it operates entirely without the lethal addiction profiles, sedation, or cognitive dulling associated with clinical benzodiazepines (e.g., Xanax). Administered intranasally, it is an elite tool for crushing acute stress responses while actively improving memory acquisition.
Quick Stats
Scientific Data
Mechanism of Action
Selank (TP-7) is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin. It has both anxiolytic (anti-anxiety) and nootropic (cognitive-enhancing) properties. Selank modulates multiple neurotransmitter systems simultaneously: GABA, serotonin, dopamine, and norepinephrine. It also enhances BDNF (Brain-Derived Neurotrophic Factor) expression.
Selank is approved in Russia as a prescription medication for anxiety and cognitive disorders. Its extremely short half-life (~3 minutes for the parent compound) necessitates intranasal administration for clinical use, where it achieves rapid CNS delivery.
Source: PMID: 18577768
Background & History
Selank is a synthetic heptapeptide analog of the endogenous immunomodulatory tetrapeptide Tuftsin (Thr-Lys-Pro-Arg), developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1990s. By adding three additional amino acids (Pro-Gly-Pro), its stability and CNS penetration were significantly enhanced. It has been approved in Russia for treatment of generalized anxiety disorder (GAD) and as a nootropic since 2009. Over 30 clinical trials have been conducted. Its anxiolytic mechanism differs from benzodiazepines — no GABA-A modulation — acting instead via enkephalin system and BDNF upregulation.
Research Use Cases
- ✓Generalized anxiety disorder without sedation or dependence
- ✓Cognitive enhancement: focus, memory consolidation, learning
- ✓Stress-induced immune suppression reversal
- ✓PTSD and fear extinction support
- ✓Nootropic protocol for mental performance under stress
Dosing Protocol
| Typical Dose | 250-750 mcg/day (intranasal) |
| Frequency | 1-3× daily (intranasal) |
| Half-Life | ~3 minutes (rapid metabolism) |
| Common Vial Sizes | 5 mg |
Dosing Protocols
Standard Protocol
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 250–750 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 193 mcg | 386 mcg | 579 mcg |
| 140 lb(63 kg) | 225 mcg | 450 mcg | 675 mcg |
| 160 lb(73 kg) | 261 mcg | 521 mcg | 782 mcg |
| 180 lb(82 kg) | 293 mcg | 586 mcg | 879 mcg |
| 200 lb(91 kg) | 325 mcg | 650 mcg | 975 mcg |
| 220 lb(100 kg) | 357 mcg | 714 mcg | 1071 mcg |
| 250 lb(113 kg) | 404 mcg | 807 mcg | 1211 mcg |
💉 For exact syringe units based on your vial concentration, use the Selank Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Anxiety / Stress Reduction
HighApproved anxiolytic in Russia. Modulates GABA, serotonin, dopamine simultaneously without sedation.
Cognitive Enhancement
ModerateBDNF upregulation supports memory and learning. Nootropic properties alongside anxiolytic effect.
Reconstitution Example
Safety & Considerations
Approved prescription medication in Russia. Good safety profile. Primary route is intranasal. Mild drowsiness possible. No significant side effects at standard doses.
Regulatory & Legal Status
Approved in Russia as a nasal spray; not FDA-approved
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
No significant drug interactions documented. Do not combine with benzodiazepines without tapering assessment. MAO inhibitors may interact with enkephalin metabolism. Intranasal administration preferred for CNS bioavailability.
Synergies & Common Stacks
Selank reduces anxiety via enkephalin pathways; Semax enhances cognition via BDNF and ACTH. Together they create an anxiolytic + cognitive enhancement stack without sedation.
Selank reduces daytime anxiety; DSIP supports slow-wave sleep restoration at night. Comprehensive stress and sleep protocol.
Selank vs. Semax
| Attribute | Selank | Semax |
|---|---|---|
| Class | Anxiolytic neuropeptide (Tuftsin analog) | ACTH analog neuropeptide |
| Primary Effects | Anxiolytic, anti-stress, mild cognitive | Stimulant, cognitive enhancer, BDNF booster |
| Energy Effect | Calming without sedation | Stimulating (energizing) |
| Best For | Anxiety, stress, calm focus | Energy, memory, BDNF-driven learning |
| Administration | Intranasal (nasal drop) | Intranasal (nasal drop) |
| Approval | Russia (Selank nasal spray) | Russia (Semax nasal spray) |
Verdict: Selank is the calming, anxiolytic choice; Semax is the stimulating, cognitive-enhancement choice. Many users stack both — Selank in the PM for de-stress, Semax in the AM for drive and focus.
Dosing Quick Reference
Frequently Asked Questions
How is Selank administered?▼
Does Selank require a prescription?▼
References
- Semenova TP et al. “"Selank (TP-7), a synthetic peptide with anxiolytic activity".” Bulletin of Experimental Biology and Medicine (2010). PMID: 21161046
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