Cognitive & Nootropic

Selank

TP-7

Tuftsin analog (TKPRPGP) with a Russian prescription story. Minutes-class half-life is why the spray exists. Not a US Xanax replacement and not Semax.

Not FDA-approved - research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: September 2026Evidence: Moderate3 peer-reviewed citations
Typical research dose
250-750 mcg/day (intranasal)
Frequency
1-3× daily (intranasal)
Half-life
~3 minutes (parent); active metabolites persist longer
Common vials
5 mg
CAS
129954-34-3
Molecular weight
751.87 g/mol

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Cognition5/10

    Russian clinical use for anxiety/cognition. Ceiling 6.5 for small human; haircut because it is not a US approved anxiolytic and nasal research SKUs are not that product.

Compound card

Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin analog)
Class
Russian Rx tuftsin analog (intranasal; not a US NDA)
Formula
C33H57N11O9
Status
Not FDA-approved · research use
Dose it
5 mg + 5 mL BAC water → 1 mg/mL · 250 mcg ≈ 25 units (U-100)
Open in calculator

How it works

Selank (TP-7) is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin. It has both anxiolytic (anti-anxiety) and nootropic (cognitive-enhancing) properties. Selank modulates multiple neurotransmitter systems simultaneously: GABA, serotonin, dopamine, and norepinephrine. It also enhances BDNF (Brain-Derived Neurotrophic Factor) expression.

Selank is approved in Russia as a prescription medication for anxiety and cognitive disorders. Its extremely short half-life (~3 minutes for the parent compound) necessitates intranasal administration for clinical use, where it achieves rapid CNS delivery.

Source: PMID: 18577768

Goal context

Anxiety / stress as the Russian label story

Selank is approved in Russia as a prescription medication for anxiety and cognitive disorders. That is not an FDA NDA and not a US Xanax replacement.

Intranasal because of minutes-class half-life

Parent-compound t½ of ~3 minutes is why the spray exists. Do not treat this like a daily SubQ GH peptide.

Background & History

Selank is a tuftsin analog (TKPRPGP) with a Russian prescription story. Minutes-class half-life is why the spray exists. Not a US Xanax replacement and not Semax.

Research Use Cases

  • ✓Tuftsin-analog identity vs N-acetyl Selank amidate
  • ✓Russian GAD/nootropic history vs a US research vial
  • ✓Not a PTSD, ADHD, or benzodiazepine-taper protocol

Dosing

PhaseDoseFrequencyNotes
Standard Protocol250 - 750 mcgDaily intranasal (1-3 doses)Approved prescription medication in Russia. Research chemical in most Western countries.

Administration

Route / form
Intranasal spray
Timing
Morning and/or afternoon. Avoid late evening (may affect sleep patterns).
Empty stomach?
No - Food timing is not critical.

Selank: Nasal spray / drops vs Research vial SubQ

Nasal spray / drops
Bioavailability
Minutes-class systemic t½ is why the spray exists. Intranasal is a CNS-delivery argument, not a published US F% table for this SKU. Do not print “~100% CNS delivery” as if it were an FDA bioavailability number.
Dose note
Reconstitute the lyophilized cake, then dose the nose. Community ranges sit in the low-hundreds of mcg per day, split 1–3×. That is research-chem / CIS practice, not a US label. Do not run a BPC-style daily SubQ chart on a nasal insert.
Advantages
  • Matches how the Russian product and most US research SKUs are actually used.
  • Short plasma t½ is the reason people do not treat this like a depot GH peptide.
  • Selank is TKPRPGP (tuftsin analog). It is not Semax and not a US benzodiazepine.
Considerations
  • Russian labeled product is nasal, not a US NDA.
  • Nasal irritation is the usual complaint. Volume and osmolarity of a reconstituted cake are not a pharmacy spray.
  • Recon math is for making a solution. It is not a BAC SubQ lifestyle protocol.
Research vial SubQ
Bioavailability
Same cake, different hole. SubQ is community use of a nasal peptide. There is no head-to-head human PK that makes the shot “stronger.” Minutes-class parent t½ still applies.
Dose note
If the bottle is lyophilized and you inject it, BAC-reconstitute and do the unit math. Community mcg numbers are borrowed from nasal practice. Food does not change the shot. This is not a second official SKU.
Advantages
  • Vial math is checkable when the COA matches the sequence.
  • Useful only if you knowingly bought a cake and chose SubQ. It does not create a US injectable drug.
Considerations
  • Not the Russian labeled route. Do not invent a clinic IM ampoule because a vendor sold powder.
  • Systemic exposure is not a published reason to skip the nose.
  • Selank is TKPRPGP (tuftsin analog). It is not Semax and not a US benzodiazepine.
Recommendation: Selank: nasal is the honest default. SubQ is the same research cake used as an injection, not a second approved product. Russian labeled product is nasal, not a US NDA. Do not flatten a spray insert into a BPC reconstitution calendar.

Timeline

Minutes to hours
Anxiolytic effects onset rapidly. Mild cognitive clarity enhancement.
Week 2-4
Sustained anxiety reduction. BDNF upregulation supports cognitive improvements.

Who it is for

Anxiety / Stress Reduction

High

Approved anxiolytic in Russia. Modulates GABA, serotonin, dopamine simultaneously without sedation.

Cognitive Enhancement

Moderate

BDNF upregulation supports memory and learning. Nootropic properties alongside anxiolytic effect.

Reconstitution

Vial
5 mg
Diluent
5 mL
Concentration
1 mg/mL
Per Unit (100u syringe)
10 mcg
Dose of 250 mcg = 25 units on a 100-unit insulin syringe

Safety & Considerations

Approved prescription medication in Russia. Good safety profile. Primary route is intranasal. Mild drowsiness possible. No significant side effects at standard doses.

Regulatory & Legal Status

FDA Status (US)
Research Only

Approved in Russia as a nasal spray; not FDA-approved

WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • Russian approval is not an FDA NDA.
  • Parent-compound t½ of minutes is why people do not treat this like a daily SubQ GH peptide.
  • N-acetyl-selank-amidate is a different SKU with no extra human PK.

Human evidence

Moderate · Russian Rx story (not a US NDA)

  • Russian approval is not an FDA NDA.
  • N-acetyl-selank-amidate is a different SKU with no extra human PK.

Verdict

Selank is a tuftsin analog with a Russian prescription story. Minutes-class half-life is why the spray exists. It is not a US Xanax replacement and not Semax.

Interactions & Contraindications

Not a benzo. Do not assume zero CNS drug interactions. Intranasal vs injectable are different products.

Synergies & Common Stacks

+ Semax →

Classic Russian pair (anxiolytic analog vs ACTH-fragment analog). Two SKUs, not a US psychiatry stack.

+ Noopept →

Same aisle in community logs. Selank is a tuftsin analog; Noopept is a dipeptide ester. Not a co-admin RCT.

Selank vs. Semax

Canonical comparison: Selank vs Semax

AttributeSelankSemax
ClassAnxiolytic neuropeptide (Tuftsin analog)ACTH analog neuropeptide
Primary EffectsAnxiolytic, anti-stress, mild cognitiveStimulant, cognitive enhancer, BDNF booster
Energy EffectCalming without sedationStimulating (energizing)
Best ForAnxiety, stress, calm focusEnergy, memory, BDNF-driven learning
AdministrationIntranasal (nasal drop)Intranasal (nasal drop)
ApprovalRussia (Selank nasal spray)Russia (Semax nasal spray)

Verdict: Selank is the calming, anxiolytic choice; Semax is the stimulating, cognitive-enhancement choice. Many users stack both - Selank in the PM for de-stress, Semax in the AM for drive and focus.

Appears in goal guides

Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.

Cognitive Enhancement & Nootropic Drive

Identity map for Semax, Selank, Noopept, and related nootropic SKUs. BDNF language is mechanism, not a US cognition or stroke indication.

View Protocol →

Cognitive Enhancement Protocol

Neuro 3 Plus bioregulator triad (brain, vessels, liver) plus Semax/Selank, with Dihexa reserved for advanced users.

View Protocol →

Immune Optimization Protocol

Thymic cytomax (Vladonix) plus Endoluten and Bonomarlot, then Thymosin Alpha-1 and Selank, with LL-37/KPV as acute experimental tools.

View Protocol →

Frequently Asked Questions

Nasal or injection?▼
Nasal is the Russian labeled route. SubQ is community use of a lyophilized cake, not a US anxiolytic. Parent t½ of minutes is why people do not treat this like a daily GH shot. N-acetyl Selank amidate is a different analog.
How is Selank administered?▼
Primarily as intranasal spray at 250-750 mcg/day, 1-3 doses. The ~3-minute half-life makes SC injection impractical - intranasal provides direct CNS access.
Does Selank require a prescription?▼
Approved prescription medication in Russia. Available as a research peptide in most Western countries.

References

  1. Semenova TP et al. “"Selank (TP-7), a synthetic peptide with anxiolytic activity".” Bulletin of Experimental Biology and Medicine (2010). PMID: 21161046
  2. Semenova TP, et al. “Anxiolytic-like effect of selank in elevated plus-maze test in rats.” Bull Exp Biol Med (2006). PMID: 17407305
  3. Kasian A, et al. “Selank has anxiolytic activity comparable to GABA-ergic compounds.” Regul Pept (2012). PMID: 22709419

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