Epithalamin
Epithalamine · Natural Epitalon extract · Эпиталамин
Epithalamin is the pharmaceutical pineal extract - the clinical ancestor of Epitalon, not a synonym for AEDG. Endoluten is the oral Cytomax complex. Our Epitalon alias list used to treat these as one thing. They are not.
Use-case scores
0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.
- Longevity / aging3.5/10
Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.
- Cognition3.5/10
Nervous/pineal/visual aisle in the school. Not a stroke or dementia label.
Compound card
- Sequence
- Pineal gland extract / historic clinic SKU
- Class
- Khavinson pharmaceutical extract (Pineal gland)
- Formula
- Polypeptide extract (Pineal tissue <10 kDa)
- Status
- Not FDA-approved · research use
How it works
Epithalamin is the pharmaceutical pineal extract in the Khavinson line: injectable mixture, not Endoluten (Cytomax capsules) and not Epitalon (AEDG). Russian clinic series exist. Longitudinal combination follow-ups are not an FDA mortality claim, and a 50% slogan is not a US label. Score the extract as school literature, not as a Western geroprotector NDA.
Source: PMID: 12937682
Khavinson map
Canonical 41Used in bioregulator stacks
Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.
The Khavinson school
Vladimir Khatskelevich Khavinson (1946–2024) spent five decades at what became the St. Petersburg Institute of Bioregulation and Gerontology arguing a simple, stubborn idea: aging is, in part, a failure of tissue-specific peptide signals, and those signals can be restored. The first products were not “peptides” in the Instagram sense. They were Cytamins - polypeptide fractions isolated from a named organ of young animals. Later commercial refinements of those fractions are sold as Cytomaxes (Cytomed / NPCRIZ): still mixtures, still oral capsules, still defined by the source organ rather than a single sequence. When the group identified short active motifs inside those mixtures, they synthesized them as Cytogens - di-, tri-, and tetrapeptides with a one-letter code (KE, AEDG, KED, EDR, KEDP, and so on).
That three-layer stack is the whole map. Cytamin / pharmaceutical extracts (Thymalin, Epithalamin, Cortexin, Retinalamin, Prostatilen) are the clinic-era injectables registered in the former Soviet pharmacopeia. Cytomaxes are the capsule complexes Cytomed still lists as a 21-SKU organ line. Cytogens are the defined synthetics. English-language educators, including Brenden Henry’s public writing at Peptide Science Institute, add a further commercial distinction - later analog SKUs (N-acetyl, amidate, “V2” complexes) sold as more stable or more diverse than the original Cytomed lots. That last layer is a product taxonomy, not a Khavinson paper. We describe it so readers are not gaslit by three bottles with the same organ name. We do not reproduce paid Peptide Mastery protocols, Precision Cell Method language, or anyone else’s course IP.
Full Cytamin → Cytomax → Cytogen map, literature limits, and how we counted 41
The mechanism Khavinson published is epigenetic, not receptor-agonist in the GLP-1 sense. Short peptides are claimed to enter nuclei, interact with DNA/histones, and reopen tissue-specific transcription that condensed with age (heterochromatin → euchromatin). Reviews in the Bulletin of Experimental Biology and Medicine and Neuroendocrinology Letters (PMID 14523363, 15677927, 23888677) are the citable core. Complementary GI pharmacology is not mystical: di- and tripeptides are PEPT1/LAT substrates, which is why oral capsules are even a conversation. What is not established in Western Phase 3 programs is organ-by-organ disease treatment, telomere reversal as a clinical endpoint, or the manufacturer claim that Cytomax is “a third stronger” than Cytogen. Those are NPCRIZ marketing sentences.
Khavinson’s group published hundreds of papers, many in Russian, many in the same journal family. That is a real literature. It is also a literature with limited independent Western replication, small n, and a habit of using one review PMID as a stamp on every organ. On this site a leaf earns its organ story, its Cytomax↔Cytogen pair, its sequence if it has one, and an honest sentence about what has not been shown. Reconstitution math belongs on cytogens sold as vials. Cytomax capsules do not get a fake 5 mg vial.
The 41 we treat as canonical are the 21 Cytomaxes on the public e-peptide/Cytomed list, the 12 Cytogens on that same commercial line (including Vesilut, which Western catalogs often drop), plus eight historically load-bearing molecules that sit beside the capsule SKUs: Epitalon, Vilon, Thymogen, Livagen, Cortagen, Prostamax, Thymalin, and Epithalamin. Honluten, Cortexin, Retinalamin, Prostatilen, Thymulin, N-acetyl-epitalon-amidate, Pinalex, and the GPL Man / GPL Femme kits are covered as adjacent - same school or same storefront, not padded into a fake 41.
Public English-language teaching (including Brenden Henry at peptidescienceinstitute.com) is cited as context, not copied. Paid Peptide Mastery / Peptide Salvation text stays theirs.
History of this molecule
Epithalamin is what Khavinson’s gerontology trials often actually injected when the English internet says “they used Epitalon.” Sometimes they used the extract. Sometimes the tetrapeptide. The products split for a reason: mixture versus AEDG.
Anisimov/Khavinson rodent and human-gerontology work on epithalamin is the extract literature. Telomerase somatic-cell work is the AEDG paper. Keep the citations on the molecule that was in the syringe.
Caveats
Extract mixture, animal source, not FDA. Not a melatonin gummy. Not automatically the telomerase experiment.
Full 41-map: Khavinson bioregulators index · Bioregulator stacks
Research Use Cases
- ✓Longevity research
- ✓Telomerase activation
- ✓Circadian rhythm restoration
- ✓Melatonin production support
- ✓Anti-aging protocols
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Historic Clinical Course | 10 mg | Daily IM injection for 10-15 days, repeated yearly | The protocol responsible for the famous Russian 15-year life extension studies. |
Administration
Epithalamin: CIS IM extract vs Not Endoluten / not AEDG
- Extract-layer object that actually went into many gerontology syringes when English blogs say “they used Epitalon.”
- Separable from AEDG and from Endoluten if you keep the names honest.
- Food does not change an IM shot.
- Mixture, animal source, not FDA. Not a melatonin gummy.
- Do not launder PMID 12937225 onto this leaf as if the tetrapeptide were in the ampoule.
- Fake 5 mg BAC charts belong on research AEDG, and only when that is what you bought.
- The map has Endoluten for oral pineal. Use that leaf for capsules.
- Stops the three-name collapse (extract / tetrapeptide / Cytomax).
- Not a sublingual tablet. Nobody manufactures this SKU that way.
- Vendor relabeling is the main oral-looking failure mode: powder sold as “epithalamin” that is AEDG.
- Mortality follow-ups: read which preparation. Blogs flatten this.
- Not NAEA.
Timeline
Who it is for
Systemic Longevity / Telomeres
ModerateThe gold standard of the Khavinson research repertoire.
Reconstitution
Safety & Considerations
Historic pharmaceutical preparation. Not widely available in the West; essentially replaced in the biohacking community by Epitalon (the synthetic active component) and Endoluten (the oral version).
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- Extract ≠ synthetic cytogen ≠ Cytomax capsule.
- Longitudinal Khavinson combination data is not an FDA mortality claim.
- This site will not treat the named organ disease from a peptide page.
Verdict
Epithalamin is the extract-era product in the Pineal gland line, not a Cytomax capsule and not a one-letter cytogen. Russian clinic history is real. A 50% mortality slogan is not a US label.
Interactions & Contraindications
Well-tolerated in long-term clinical use. May interact with exogenous melatonin supplementation. Standard injectable protocol in Russian clinical practice.
Synergies & Common Stacks
Epithalamin is the natural extract, Epitalon is the purified synthetic tetrapeptide. Both target pineal function and telomerase but through slightly different compositions.
The Epithalamin + Thymalin combination is the original Khavinson longevity protocol that showed 46% mortality reduction in the 15-year study.
Epithalamin (injectable) and Endoluten (oral capsule) both originate from pineal tissue - different delivery forms of similar bioactive peptides.
Frequently Asked Questions
Epithalamin vs Epitalon vs Endoluten?▼
Which one was in the longevity studies?▼
Single sequence?▼
Same CAS as Epitalon?▼
IM or oral?▼
How do Epithalamin, Endoluten, and Epitalon relate?▼
References
- Khavinson VKh, Anisimov VN et al. “Epithalamin and geroprotective effects (extract literature).” Neuroendocrinology Letters / Bull Exp Biol Med (2003). PMID: 12937682
- Khavinson VKh “Peptides and ageing.” Neuroendocrinology Letters (2002). PMID: 12374906
- Khavinson VKh, Anisimov VN “Peptide bioregulators: a new class of geroprotectors. Message 1: results of experimental studies.” Bulletin of Experimental Biology and Medicine (2000). PMID: 11182816
- Khavinson VKh, Anisimov VN “"Peptide preparation Epithalamin increases the lifespan of rats".” Mechanisms of Ageing and Development (2001). PMID: 11470138
📚 Related Articles
Get Epithalamin from Vita-Stream - a distributor for Khavinson-line oral capsules. No reconstitution math on a Cytomax bottle.
Affiliate link · Full review