Epithalamin
Epithalamin is the legendary, towering Cytomax extraction derived directly from the pineal glands of young animals. As the raw, natural predecessor of the synthetic Epitalon, it represents the absolute apex of systemic longevity research. It famously served as the exact compound used in Khavinson’s landmark 15-year human mortality studies, where it was proven to radically extend lifespan, drastically slash all-cause mortality, and forcefully reverse systemic cellular senescence in elderly cohorts.
Quick Stats
Scientific Data
Mechanism of Action
Epithalamin is the original, legendary purified polypeptide extract from the pineal glands of cattle, developed by Vladimir Khavinson for the Soviet military in the 1980s. It is the sterile, injectable pharmaceutical precursor to the oral Cytomax Endoluten and the blueprint for the synthetic tetrapeptide Epitalon.
Administered intramuscularly, Epithalamin directly restores pineal gland function. In historic 15-year longitudinal clinical trials in elderly populations, Epithalamin was shown to reset circadian melatonin rhythms, upregulate telomerase activity, dramatically enhance T-cell immunity, and cut all-cause mortality rates by nearly 50%. It is arguably the most extensively human-tested anti-aging peptide sequence in history.
Source: PMID: 12937682
Background & History
Epithalamin holds a unique position in bioregulator history as the preparation used in Khavinson's most famous clinical trial — the 15-year mortality study published in 2003. In this study, elderly patients (60-80 years) receiving annual courses of Epithalamin + Thymalin showed 46% lower mortality compared to controls. Epithalamin is extracted from bovine pineal glands and is the natural multi-peptide precursor from which synthetic Epitalon (AEDG) was later isolated and characterized.
Research Use Cases
- ✓Longevity research
- ✓Telomerase activation
- ✓Circadian rhythm restoration
- ✓Melatonin production support
- ✓Anti-aging protocols
Dosing Protocol
| Typical Dose | 5-10 mg IM |
| Frequency | 1× daily for 10-20 day cycles |
| Half-Life | ~3 hours |
| Common Vial Sizes | 5 mg, 10 mg |
Dosing Protocols
Historic Clinical Course
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 5000–10000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 3857 mcg | 5786 mcg | 7714 mcg |
| 140 lb(63 kg) | 4500 mcg | 6750 mcg | 9000 mcg |
| 160 lb(73 kg) | 5214 mcg | 7821 mcg | 10429 mcg |
| 180 lb(82 kg) | 5857 mcg | 8786 mcg | 11714 mcg |
| 200 lb(91 kg) | 6500 mcg | 9750 mcg | 13000 mcg |
| 220 lb(100 kg) | 7143 mcg | 10714 mcg | 14286 mcg |
| 250 lb(113 kg) | 8071 mcg | 12107 mcg | 16143 mcg |
💉 For exact syringe units based on your vial concentration, use the Epithalamin Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Systemic Longevity / Telomeres
ModerateThe gold standard of the Khavinson research repertoire.
Reconstitution Example
Safety & Considerations
Historic pharmaceutical preparation. Not widely available in the West; essentially replaced in the biohacking community by Epitalon (the synthetic active component) and Endoluten (the oral version).
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Well-tolerated in long-term clinical use. May interact with exogenous melatonin supplementation. Standard injectable protocol in Russian clinical practice.
Synergies & Common Stacks
Epithalamin is the natural extract, Epitalon is the purified synthetic tetrapeptide. Both target pineal function and telomerase but through slightly different compositions.
The Epithalamin + Thymalin combination is the original Khavinson longevity protocol that showed 46% mortality reduction in the 15-year study.
Epithalamin (injectable) and Endoluten (oral capsule) both originate from pineal tissue — different delivery forms of similar bioactive peptides.
Dosing Quick Reference
Frequently Asked Questions
How do Epithalamin, Endoluten, and Epitalon relate?▼
References
- Khavinson VKh, Anisimov VN “"Peptide preparation Epithalamin increases the lifespan of rats".” Mechanisms of Ageing and Development (2001). PMID: 11470138
- Khavinson VKh et al. “"Peptide geroprotector from the pineal gland produces telomerase-inducing effect".” Bulletin of Experimental Biology and Medicine (2003). PMID: 12937682
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Get Epithalamin from Vita-Stream — the comprehensive distributor for authentic Khavinson bioregulators. Oral capsules, no injections required.
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