Livagen
Livagen (Lys-Glu-Asp-Ala) is an incredibly advanced Khavinson tetrapeptide bioregulator recognized as the gold standard for profound hepatic (liver) regeneration and systemic epigenetic reprogramming. It holds the unique clinical distinction of being one of the first proven compounds to physically decondense heterochromatin in elderly individuals. It is deployed specifically to rapidly regenerate cirrhotic or highly toxic liver tissue, rapidly restoring the organ's massive detoxification capabilities and violently reversing deep cellular senescence.
Quick Stats
Scientific Data
Mechanism of Action
Livagen (Lys-Glu-Asp-Ala) is a tetrapeptide bioregulator targeting hepatocyte (liver cell) gene expression and chromatin structure. It restores liver metabolic enzyme production, detoxification gene expression, and hepatocellular regeneration capacity in aged cells. Khavinson demonstrated chromatin relaxation in hepatocytes treated with Livagen, restoring transcription of liver-specific proteins suppressed by aging.
Source: PMID: 14564402
Background & History
Livagen (Lys-Glu-Asp-Ala) is notable for being one of the first peptides proven to decondense pericentromeric heterochromatin — literally "unlocking" genes silenced by aging. This epigenetic effect plus hepatoprotection makes it unique among bioregulators.
Research Use Cases
- ✓Epigenetic rejuvenation research
- ✓Hepatoprotection and liver regeneration
- ✓Anti-aging through chromatin remodeling
- ✓Liver detoxification support
Dosing Protocol
| Typical Dose | 10-20 mg/day (oral) or 1-2 mg SC |
| Frequency | 1× daily for 10-30 day cycles |
| Half-Life | ~30 minutes (estimated) |
| Common Vial Sizes | 5 mg, 10 mg |
Dosing Protocols
Khavinson Protocol
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 1000–20000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 771 mcg | 8100 mcg | 15429 mcg |
| 140 lb(63 kg) | 900 mcg | 9450 mcg | 18000 mcg |
| 160 lb(73 kg) | 1043 mcg | 10950 mcg | 20857 mcg |
| 180 lb(82 kg) | 1171 mcg | 12300 mcg | 23429 mcg |
| 200 lb(91 kg) | 1300 mcg | 13650 mcg | 26000 mcg |
| 220 lb(100 kg) | 1429 mcg | 15000 mcg | 28571 mcg |
| 250 lb(113 kg) | 1614 mcg | 16950 mcg | 32286 mcg |
💉 For exact syringe units based on your vial concentration, use the Livagen Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Hepatic Aging / Liver Health
LowLiver-specific bioregulator. Restores hepatocyte gene expression suppressed by aging.
Reconstitution Example
Safety & Considerations
Research peptide. Extensively used in Russian clinical protocols. Excellent safety profile in elderly populations.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Standard Khavinson protocol. Epigenetic effects are tissue-selective. Well tolerated.
Synergies & Common Stacks
Livagen (heterochromatin decondensation) + Epitalon (telomerase activation) = dual epigenetic aging intervention targeting both gene accessibility and telomere maintenance.
Livagen (synthetic hepatoprotective peptide) + Svetinorm (liver Cytomax extract) = comprehensive liver support through complementary bioregulator approaches.
Dosing Quick Reference
Frequently Asked Questions
What liver functions does Livagen restore?▼
References
- Khavinson VKh et al. “"Short peptides restore chromatin structure and gene function in aging hepatocytes".” Bulletin of Experimental Biology and Medicine (2017). PMID: 28695688
📚 Related Articles
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