MGF
MGF (Mechano Growth Factor), precisely known as the IGF-1Ec splice variant, is the raw, unadulterated "first responder" peptide generated endogenously the exact second a muscle fiber suffers mechanical overload (trauma). Because it completely lacks the protective PEGylation of its systemic variant, synthetic MGF possesses a brutally short half-life of roughly 5 to 7 minutes in plasma. Consequently, it must be injected intra-muscularly directly into a traumatized, lagging muscle group immediately post-training to force extreme localized hyperplasia.
Quick Stats
Mechanism of Action
MGF (Mechano Growth Factor, IGF-1Ec) is a splice variant of IGF-1 produced locally in damaged muscle tissue. When muscle fibers experience mechanical load and micro-damage, the IGF-1 gene is alternatively spliced to produce MGF instead of systemic IGF-1.
MGF activates satellite cells (muscle stem cells) precisely at the injury site, initiating the repair and hypertrophy process. Its extremely short half-life (~5-7 minutes) makes it a highly localized signal — it must be injected directly into or near the target muscle to be pharmacologically active. This same half-life also means it degrades before causing systemic effects.
Source: PMID: 12620066
Background & History
MGF (Mechano Growth Factor) is the native, non-PEGylated splice variant of IGF-1 generated after mechanical load or injury. It contains a unique 24-amino-acid E-domain that distinguishes it from systemic IGF-1 and specifically activates quiescent muscle satellite cells. The E-domain peptide has also been shown to have direct cardiac and neuroprotective effects independent of satellite cell activation. Its 2-minute half-life in blood means local injection near muscle is essential for activity.
Research Use Cases
- ✓Immediate post-injury satellite cell activation (inject locally)
- ✓Cardiac protection post-ischemia via independent E-domain mechanism
- ✓Neuroprotection in CNS injury models
Dosing Protocol
| Typical Dose | 100-200 mcg per site |
| Frequency | 1× daily (post-training) |
| Half-Life | ~5-7 minutes |
| Common Vial Sizes | 2 mg, 5 mg |
Dosing Protocols
Local Injection Protocol
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 100–200 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 77 mcg | 116 mcg | 154 mcg |
| 140 lb(63 kg) | 90 mcg | 135 mcg | 180 mcg |
| 160 lb(73 kg) | 104 mcg | 156 mcg | 209 mcg |
| 180 lb(82 kg) | 117 mcg | 176 mcg | 234 mcg |
| 200 lb(91 kg) | 130 mcg | 195 mcg | 260 mcg |
| 220 lb(100 kg) | 143 mcg | 214 mcg | 286 mcg |
| 250 lb(113 kg) | 161 mcg | 242 mcg | 323 mcg |
💉 For exact syringe units based on your vial concentration, use the MGF Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Targeted Muscle Repair
LowThe most targeted muscle growth factor. Works only locally — ideal for lagging muscles or injury recovery.
Reconstitution Example
Safety & Considerations
Research peptide. Must be injected locally (intramuscular or subcutaneous near target). Very short half-life means systemic injection is ineffective — use immediately after reconstitution. Do not freeze after reconstitution.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Must be injected directly into or near target muscle tissue due to 2-minute serum half-life. No systemic activity from non-local injection. As an IGF-1 family peptide: contraindicated with active cancer. Localized hypoglycemia risk at injection site is minimal.
Synergies & Common Stacks
MGF provides immediate local satellite cell activation (short burst); PEG-MGF extends this signal for 48-72 hours. Sequential protocol for maximum muscle repair.
MGF activates satellite cells; IGF-1 LR3 drives them to proliferate and differentiate. Complete myogenic cascade activation.
Dosing Quick Reference
Frequently Asked Questions
Why must MGF be injected locally?▼
When should I inject MGF?▼
References
- Goldspink G “"Mechano growth factor: a tissue specific anabolic growth factor".” Biochemical Society Transactions (2002). PMID: 12196225
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