Healing & Recovery

MGF

Mechano Growth Factor · IGF-1Ec

MGF is the IGF-1Ec splice produced locally after mechanical load. Synthetic research-chem MGF is minutes-class in plasma, which is why local injection folklore exists. Goldspink’s splice biology is real. A 5 mg vial is not a satellite-cell drug, and it is not PEG-MGF.

Not FDA-approved - research chemical

Reviewed by CalcMyPeptide Editorial Team

·Last updated: August 2026·Evidence: Low·2 peer-reviewed citations

Typical research dose

100-200 mcg per site

Frequency

1× daily (post-training)

Half-life

~minutes in plasma for native peptide; SKU PK unpublished

Common vials

2 mg / 5 mg

CAS

N/A

Molecular weight

E-domain fragment class (~2–3 kDa); confirm the COA

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Muscle / recomp3/10
Splice biology is real. Injectable gray-market MGF is not a hypertrophy RCT. Community ceiling.
Injury & tissue3/10
Load-injury conversation is the origin story. Not a tendon trial.

Compound card

Sequence: IGF-1Ec E-domain / MGF (vendor fragments vary)
Class: IGF-1Ec splice (native MGF), not PEG-MGF, not IGF-1 LR3
Formula: IGF-1Ec / E-peptide class (vendor-dependent)
Status: Not FDA-approved · research use

Dose it

2 mg + 2 mL BAC water → 1 mg/mL · 100 mcg ≈ 10 units (U-100)

Open in calculator

How it works

Mechano growth factor is the IGF-1Ec splice produced locally after load. Goldspink 2002 (PMID 12196225) is the biology paper this page should cite. Native peptide is minutes-class in plasma, which is why local-injection folklore exists. A research-chem vial is a synthetic fragment or analog, not the splice event inside your muscle.

It is not PEG-MGF (the PEGylated SKU) and not IGF-1 LR3. “Lagging body-part hyperplasia in 6 weeks” is forum physics. Mitogenic IGF-family signaling is why active malignancy is a stay-out.

Source: PMID: 12620066

Confirm you do not have PEG-MGF

If the COA says PEGylated, use the PEG-MGF leaf. Native-MGF local-injection folklore does not apply to a multi-day analog.

Goal context

Local vs systemic

Minutes-class clearance is why people chase the muscle they just trained. That is a kinetic heuristic, not proof of site-specific hyperplasia.

Three SKUs, one search

MGF, PEG-MGF, IGF-1 LR3. Different pages. Do not stack all three because a forum tree said “complete cascade.”

Background & History

MGF is the IGF-1Ec splice after mechanical load (Goldspink). Native peptide is minutes-class, which is why local-injection folklore exists. A research vial is not that splice event. Not PEG-MGF, not IGF-1 LR3.

Research Use Cases

✓Native-MGF / E-domain identity
✓Not a lagging-body-part hyperplasia drug

Dosing

Phase	Dose	Frequency	Notes
Community local (unlabeled)	100–200 mcg	Post-training, local IM or SC	Copied range. Not a label. Use promptly after reconstitution if the analog is truly short-lived.

Administration

Route / form

Local IM or nearby SC in community practice. Not a diagnostic infusion.

Timing

Immediately post-training is the story. That mimics endogenous splice timing, not a PK study of the vial.

Empty stomach?

No - Food timing is not critical.

Timeline

Minutes

If it is really native-class MGF, it is gone. Do not wait until tomorrow to inject “today’s workout.”

Weeks

No honest consumer hypertrophy timeline.

Who it is for

Need native-MGF identity

Low

This leaf. Biology real, SKU weak.

Need PEGylated

Low

PEG-MGF page.

Reconstitution

Vial	Water	Concentration	Example dose
2 mg	2.0 mL BAC	1 mg/mL	100 mcg = 0.10 mL = 10 units on a U-100 syringe. Draw and use; this is not a week-long reconstituted picnic if the analog is truly short-lived.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research IGF-family peptide. Active cancer is a stay-out. Identity errors (PEG vs native vs LR3) are the practical hazard. Sterile IM still matters.

Regulatory & Legal Status

FDA Status (US)

Research Only

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

PMID 12196225 is native splice biology, not a dosing insert for a 2 mg vial.
Vendor “MGF” may be the E-peptide, a fragment, or a mislabeled PEG analog. Read the COA.
No completed human hypertrophy RCT of research-chem MGF.

Verdict

MGF is a real splice variant and a weak research-chem SKU. Injecting it in a lagging muscle is folklore built on minutes-class clearance, not a satellite-cell drug approval. Use PEG-MGF only if that is what is on the COA.

Interactions & Contraindications

IGF-family mitogenic caution in active cancer. Identity errors (PEG vs native vs LR3) are the practical hazard.

Synergies & Common Stacks

+ PEG-MGF →

If the COA is PEGylated, you are on the other leaf. Native local-injection folklore does not apply to a multi-day analog.

Frequently Asked Questions

Why do people inject it locally?▼

Native MGF is minutes-class. Local injection is a kinetic bet, not a proven site-enhancement trial.

MGF vs PEG-MGF vs LR3?▼

MGF = splice/E-domain story. PEG-MGF = longer analog. LR3 = long IGF-1 at IGF1R. Three leaves.

How do I reconstitute a 2 mg vial?▼

Add 2.0 mL BAC for 1 mg/mL. 100 mcg is 0.10 mL (10 units).

Is the half-life 5–7 minutes?▼

That is the native-peptide class figure. Your lot is whatever the COA says. We will not pretend we PK’d it.

Can I keep reconstituted MGF for 28 days?▼

If it is truly short-lived and labile, lingering reconstituted solution is a quality bet, not a BAC-water rule. When unsure, mix what you will use.

FDA-approved?▼

No.

WADA?▼

Growth-factor related. Assume prohibited until a specialist reads the list.

Stack with BPC-157?▼

Common. Not a synergy RCT.

References

Goldspink G “Mechano growth factor: a tissue specific anabolic growth factor.” Biochem Soc Trans (2002). PMID: 12196225
Goldspink G. “Mechano growth factor splice variant of IGF-I and muscle repair.” J Physiol (2005). PMID: 15845583

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