Pancragen
Pancragen (Lys-Glu-Asp-Trp) is a synthetic Khavinson tetrapeptide engineered specifically for the extreme epigenetic modulation of the pancreas. Crucial for metabolic longevity, it is deployed not merely to manage blood glucose, but to actually biologically salvage the pancreas itself. Highly regarded in restorative protocols aiming to reverse the early stages of insulin resistance, protect failing beta-cells from hyperglycemic burnout, and massively enhance deep metabolic regulation.
Quick Stats
Scientific Data
Mechanism of Action
Pancragen (Lys-Glu-Asp-Trp) is a tetrapeptide bioregulator targeting pancreatic tissue. It normalizes pancreatic islet cell function, promoting healthy insulin synthesis and glucose metabolism. Khavinson studies demonstrate improved insulin sensitivity, standardized glucose tolerance, and preservation of beta-cell function in aging models and early-stage metabolic syndrome.
Source: PMID: 15677927
Background & History
Pancragen (KEDW) targets pancreatic beta cells for insulin synthesis support.
Research Use Cases
- ✓Metabolic support
- ✓Beta-cell preservation
- ✓Pre-diabetic protocols
Dosing Protocol
| Typical Dose | 10-20 mg/day (oral) or 1-2 mg SC |
| Frequency | 1× daily for 10-30 day cycles |
| Half-Life | ~30 minutes (estimated) |
| Common Vial Sizes | 5 mg, 10 mg |
Dosing Protocols
Khavinson Protocol
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 1000–20000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 771 mcg | 8100 mcg | 15429 mcg |
| 140 lb(63 kg) | 900 mcg | 9450 mcg | 18000 mcg |
| 160 lb(73 kg) | 1043 mcg | 10950 mcg | 20857 mcg |
| 180 lb(82 kg) | 1171 mcg | 12300 mcg | 23429 mcg |
| 200 lb(91 kg) | 1300 mcg | 13650 mcg | 26000 mcg |
| 220 lb(100 kg) | 1429 mcg | 15000 mcg | 28571 mcg |
| 250 lb(113 kg) | 1614 mcg | 16950 mcg | 32286 mcg |
💉 For exact syringe units based on your vial concentration, use the Pancragen Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Metabolic / Pancreatic Health
LowPancreatic bioregulator. Restores age-suppressed pancreatic gene expression.
Reconstitution Example
Safety & Considerations
Research peptide. Extensively used in Russian clinical protocols. Excellent safety profile.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Monitor blood glucose in diabetic patients.
Synergies & Common Stacks
Pancragen (synthetic beta-cell targeted) + Suprefort (whole pancreas Cytomax) = comprehensive pancreatic support.
Dosing Quick Reference
Frequently Asked Questions
What does Pancragen do for metabolism?▼
References
- Khavinson VKh et al. “"Peptide regulation of pancreatic function in aging".” Advances in Gerontology (2008). PMID: 18402695
📚 Related Articles
Get Pancragen from Vita-Stream — the comprehensive distributor for authentic Khavinson bioregulators. Oral capsules, no injections required.
Affiliate link · Full review