Pinealon
Pinealon is a revolutionary Khavinson bioregulator tripeptide (Glu-Asp-Arg) that serves as a master neuro-protective and geroprotective agent. By directly modulating the pineal gland and cortical gene expression, it acts as a biological "reset" for the central nervous system. It is clinically utilized to aggressively restore youthful cognitive function, normalize circadian rhythm architecture, and shield neurons from the catastrophic oxidative damage associated with advanced aging and neurodegenerative decline.
Quick Stats
Scientific Data
Mechanism of Action
Pinealon (Glu-Asp-Arg, EDR) is a synthetic tripeptide bioregulator developed by Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. It specifically targets central nervous system tissues, particularly the pineal gland and cortical neurons.
Pinealon penetrates the nuclear membrane of neuronal cells and interacts directly with DNA, modulating gene expression related to neuroprotection, antioxidant defense, and melatonin synthesis. In vitro studies demonstrate that Pinealon reduces markers of oxidative stress (ROS) in cortical neuron cultures by 30-40%.
As a pineal gland bioregulator, it normalizes melatonin production — which naturally declines with age — supporting circadian rhythm regulation, sleep quality, and the endogenous antioxidant cascade that melatonin drives. Khavinson's group has published over 30 papers demonstrating short peptide bioregulators ability to regulate gene expression epigenetically.
Source: PMID: 18402693
Background & History
Pinealon (Glu-Asp-Arg, EDR) is a synthetic tripeptide bioregulator developed by Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. It specifically targets central nervous system tissues, particularly pineal gland and cortical neurons. Unlike most neuropeptides, Pinealon penetrates the nuclear membrane of neuronal cells and interacts directly with DNA, modulating gene expression related to neuroprotection, antioxidant defense, and melatonin synthesis. Over 30 peer-reviewed publications from Khavinson's group document its effects.
Research Use Cases
- ✓Neuroprotection in age-related cognitive decline and dementia
- ✓Sleep quality improvement via melatonin production restoration
- ✓Circadian rhythm normalization (shift workers, jet lag)
- ✓Antioxidant defense in cortical neurons (reduces ROS by 30-40% in vitro)
- ✓Stroke and TBI neuroprotection (animal models)
Dosing Protocol
| Typical Dose | 10-20 mg/day (oral/nasal) or 1-2 mg SC |
| Frequency | 1× daily for 10-30 day cycles |
| Half-Life | ~30 minutes (estimated) |
| Common Vial Sizes | 5 mg, 10 mg |
Dosing Protocols
Oral Protocol (Most Common)
Injectable Protocol
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 1000–20000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 771 mcg | 8100 mcg | 15429 mcg |
| 140 lb(63 kg) | 900 mcg | 9450 mcg | 18000 mcg |
| 160 lb(73 kg) | 1043 mcg | 10950 mcg | 20857 mcg |
| 180 lb(82 kg) | 1171 mcg | 12300 mcg | 23429 mcg |
| 200 lb(91 kg) | 1300 mcg | 13650 mcg | 26000 mcg |
| 220 lb(100 kg) | 1429 mcg | 15000 mcg | 28571 mcg |
| 250 lb(113 kg) | 1614 mcg | 16950 mcg | 32286 mcg |
💉 For exact syringe units based on your vial concentration, use the Pinealon Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Sleep Quality / Circadian Rhythm
ModerateNormalizes pineal melatonin production rather than flooding receptors with exogenous melatonin. More physiological approach.
Neuroprotection
LowReduces cortical oxidative stress markers in vitro. Human evidence is limited to Russian clinical practice.
Longevity / Bioregulator Protocol
LowKhavinson data shows synergy with Epitalon. Used together for combined telomerase activation and neuroprotection.
Reconstitution Example
Safety & Considerations
Excellent safety profile based on 10+ years of Russian clinical use. May potentiate sedative effects due to melatonin pathway modulation. Avoid combining with exogenous melatonin without medical guidance. Not FDA-approved. Well-tolerated in available clinical data.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
May potentiate sedative/melatonin effects — avoid combining with melatonin supplements (additive pineal stimulation). Standard Khavinson protocol: 10-30 day cycles, 2-3 cycles per year. No significant drug interactions documented in published research. Available in oral, nasal, or injectable forms.
Synergies & Common Stacks
Both are Khavinson pineal bioregulators — Epitalon restores telomerase and melatonin secretory capacity; Pinealon protects neuronal DNA. Often used in sequence: Epitalon for longevity, Pinealon for cognitive and sleep support.
Semax provides exogenous BDNF/NGF signaling; Pinealon protects the neurons from oxidative damage. Complementary neuroprotective-nootropic stack.
Dosing Quick Reference
Frequently Asked Questions
What is the difference between Pinealon and Epitalon?▼
How is Pinealon administered?▼
Does Pinealon improve sleep?▼
References
- Khavinson VKh et al. “"Short Peptides as New Anti-Age Factors".” Advances in Gerontology (2013). PMID: 23888677
📚 Related Articles
Get Pinealon from Vita-Stream — the comprehensive distributor for authentic Khavinson bioregulators. Oral capsules, no injections required.
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