Growth Hormone

Sermorelin + Ipamorelin Combo

Serm/Ipa Stack · GHRH + GHRP Stack

Two peptides in one syringe or compounded vial: GHRH(1-29) plus ipamorelin. Dual-receptor synergy is pharmacology. “Golden ratio anti-aging” is marketing. Do the math on the actual fill.

Not FDA-approved - research chemicalWADA (S2) - prohibited in sport at all times

Reviewed by CalcMyPeptide Editorial Team

·Last updated: August 2026·Evidence: Moderate·2 peer-reviewed citations

Typical research dose

100-300 mcg each per injection

Frequency

1-2× daily (before bed)

Half-life

Sermorelin: ~20-30 min SC | Ipamorelin: ~2 hours SC

Common vials

5 mg / 10 mg

CAS

Sermorelin: 86168-78-7 | Ipamorelin: 170851-70-4

Molecular weight

Sermorelin: 3357.93 g/mol | Ipamorelin: 711.87 g/mol

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Muscle / recomp4/10
Same community ceiling as the two parents. A premix vial is convenience, not a new RCT.
Recovery & sleep3.5/10
Night dosing is the usual story. Not a sleep trial of the blend.

Compound card

Sequence: GHRH(1-29) + ipamorelin (premix SKU)
Class: Two-peptide stack, not a single analog
Formula: Combination: Sermorelin (C149H246N44O42S) + Ipamorelin (C38H49N9O5)
Status: Not FDA-approved · research use

Dose it

9 mg + 3 mL BAC water → 3 mg/mL · 200 mcg ≈ 7 units (U-100)

Open in calculator

How it works

The Sermorelin + Ipamorelin combination is a GHRH + GHRP mix sold as one SKU. Sermorelin (GHRH analog) and ipamorelin (GHS-R1a agonist) hit different pituitary receptors. That is why clinics combine them.

Together they can produce a larger GH pulse than either alone in classic GHRH+GHRP physiology. A “2–5× greater than either peptide alone” sentence is a forum multiplier, not a labeled blend endpoint. A premix vial is still two molecules. Do the reconstitution math on the actual fill, not a BPC chart.

Source: See individual peptides

Background & History

Two peptides in one syringe or compounded vial: GHRH(1-29) plus ipamorelin. Dual-receptor synergy is pharmacology. “Golden ratio anti-aging” is marketing. Do the math on the actual fill.

Research Use Cases

✓Blend identity: read the sermorelin leaf and the ipamorelin leaf
✓Why two receptors are not a printed 2–5× trial endpoint
✓Not a safer-than-HGH wellness NDA

Dosing

Phase	Dose	Frequency	Notes
Standard Combination	200-300 mcg Sermorelin + 200 mcg Ipamorelin	Nightly before bed (SC)	Combined in same syringe or pre-mixed vial. Inject on empty stomach (1+ hours after food). Most prescribed GHRH+GHRP combination.
High-Output Stack	300 mcg Sermorelin + 300 mcg Ipamorelin	2x daily - AM (fasted) + PM (before bed)	Two daily pulses for accelerated GH optimization. Requires consistent dosing for 3-6 months minimum.

Administration

Route / form

Subcutaneous injection

Timing

Before bed on an empty stomach (minimum 1-hour fast). Morning dose fasted if using 2x/day.

Empty stomach?

Yes - Empty stomach (typical for this injectable class).

Timeline

Week 1-2

Improved sleep quality and vivid dreams (amplified nocturnal GH pulse). Mild flushing with first doses.

Month 1-3

Enhanced recovery, skin quality improvements, gradual body composition changes.

Month 3-6

Peak benefits: sustained lean mass gains, fat redistribution, elevated IGF-1.

Who it is for

GH Optimization / Anti-Aging

Moderate

Two peptides, two receptors. Clinic popularity is not a labeled anti-aging NDA.

Sleep & Recovery

Low

Nocturnal GH pulse is physiology. Vivid dreams are not a sleep trial.

Body Composition

Low

Secretagogues are not a hypertrophy NDA. Do the math on the actual fill.

Reconstitution

Vial	Water	Concentration	Example dose
9 mg combined cake (example)	3.0 mL BAC	3 mg/mL combined	Check the label for the actual sermorelin:ipa ratio. Combined mg is not 1:1 of each.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Flushing, headache, and injection-site irritation show up with GHRH analogs. Feedback-loop language does not make a blend safer than somatropin. Active malignancy is a hard no. Glucose watching belongs with any GH-axis tool.

Regulatory & Legal Status

FDA Status (US)

Research Only

Combination stack - Sermorelin available via compounding; Ipamorelin is research grade

WADA Status (2026)

Prohibited (S2)

Competitive athletes subject to anti-doping controls should not use Sermorelin + Ipamorelin Combo.

Classification

Compounded Drug (Rx)

US Compounding: Available via licensed pharmacy Rx

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

No blend RCT that prints a 2–5× multiplier at 200/200 mcg bedtime.
Walker PMID 18046908 is an editorial about sermorelin, not this mix.
Premix ratios (3:3, 6:3) are compounding choices. Do the math per vial.

Verdict

This is two peptides in one syringe or one compounded vial. Read the sermorelin leaf and the ipamorelin leaf. Dual-receptor synergy is real pharmacology. “2–5× GH” and “golden ratio anti-aging” are marketing.

Interactions & Contraindications

Empty stomach for pulses. Glucose watching. Active cancer is a hard no. Premix stability is compounding, not a monograph.

Synergies & Common Stacks

+ MK-677 →

Three GH-axis tools is a monitoring problem. Not 24-hour coverage to print as a protocol.

Frequently Asked Questions

Why combine Sermorelin and Ipamorelin instead of using one alone?▼

Different receptors: GHRH vs GHS-R1a. That can mean a bigger pulse than either alone. Treat a printed 2–5× as marketing unless you cite the paper and the doses.

What dose should I use for the Sermorelin + Ipamorelin combo?▼

Standard protocol: 200-300 mcg of each peptide, combined in one syringe, administered subcutaneously before bed on an empty stomach. Pre-mixed vials commonly contain 3:3 or 6:3 mg ratios.

How long until I see results from the Serm/Ipa stack?▼

Sleep quality: 1-2 weeks. Recovery improvements: 2-4 weeks. Body composition changes: 8-12 weeks. Full benefits require consistent daily dosing for 3-6 months minimum.

References

Walker RF “"Sermorelin: a better approach to management of adult-onset GH insufficiency?".” Clinical Interventions in Aging (2006). PMID: 18046908
Bowers CY. “Combination GHRH + GHRP for synergistic GH release.” J Clin Endocrinol Metab (1998). PMID: 9765546

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