CalcMyPeptide
Khavinson BioregulatorAlso known as: Testes Bioregulator Tripeptide, Testicular Peptide

Testagen

Testagen is a hyper-targeted Khavinson synthetic tripeptide precisely engineered for total epigenetic mastery over male testicular function. Standing far above temporary exogenous hormone replacement, Testagen is utilized in aggressive male optimization protocols to physically restore testicular volume, radically accelerate massive endogenous testosterone production, and forcefully reverse the biological clock on Leydig cell senescence.

Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Low1 peer-reviewed citation

Quick Stats

Half-LifeShort (tetrapeptide)
Dose Range10-20 mg/day (oral) or 1-2 mg SC
Frequency1× daily for 10-30 day cycles
Vial Sizes5 mg, 10 mg
BioavailabilitySublingual or subcutaneous injection
Year Developed1990s

Scientific Data

Molecular Formula
C15H25N5O9
Molecular Weight
419.39 g/mol
CAS Number
PubChem ID

Mechanism of Action

Testagen (Lys-Glu-Asp-Gly) is a tetrapeptide bioregulator targeting testicular tissue. It promotes the restoration of testicular cell gene expression, supporting Leydig cell function (testosterone production) and spermatogenesis. It is used in Khavinson protocols to address age-related decline in male endocrine function, restoring the body's natural rhythm rather than replacing exogenous hormones.

Source: PMID: 15677927

Background & History

Testagen targets testicular Leydig cells for testosterone biosynthesis gene expression.

Research Use Cases

  • Male hormonal health
  • Age-related testosterone decline support
  • Hormone optimization protocols

Dosing Protocol

Typical Dose10-20 mg/day (oral) or 1-2 mg SC
Frequency1× daily for 10-30 day cycles
Half-Life~30 minutes (estimated)
Common Vial Sizes5 mg, 10 mg

Dosing Protocols

Khavinson Protocol

Dose
10 - 20 mg
Frequency
Daily SubQ for 10 days, 1-2x per year
Note: Testicular bioregulator. Usually paired with Endoluten (pineal) and Libidon (prostate) for male health.

Body-Weight Dosing Reference

Estimated doses extrapolated from the published research range of 100020000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.

WeightLowTargetHigh
120 lb(54 kg)771 mcg8100 mcg15429 mcg
140 lb(63 kg)900 mcg9450 mcg18000 mcg
160 lb(73 kg)1043 mcg10950 mcg20857 mcg
180 lb(82 kg)1171 mcg12300 mcg23429 mcg
200 lb(91 kg)1300 mcg13650 mcg26000 mcg
220 lb(100 kg)1429 mcg15000 mcg28571 mcg
250 lb(113 kg)1614 mcg16950 mcg32286 mcg

💉 For exact syringe units based on your vial concentration, use the Testagen Reconstitution Calculator →

Administration

Route
Sublingual tablets or subcutaneous injection
Timing
Morning.
Fasting Required?
No — food timing not critical

Expected Timeline

Day 1-10 (course)
Testicular gene expression restoration initiated.
Month 3-6
Improved endogenous testosterone markers and vitality.

Who Is It For?

Male Endocrine Aging

Low

Testicular bioregulator. Restores age-suppressed testicular gene expression without shutting down HPTA.

Reconstitution Example

Vial
5 mg
Water
2.5 mL
Concentration
2 mg/mL
Per Unit (100u syringe)
20 mcg
Dose of 1000 mcg = 50 units on a 100-unit insulin syringe

Safety & Considerations

Research peptide. Extensively used in Russian clinical protocols. Does NOT shut down natural testosterone production like TRT.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Interactions & Contraindications

Standard Khavinson protocol. Monitor testosterone levels.

Synergies & Common Stacks

Testagen (synthetic) + Testoluten (testicular Cytomax) = layered male reproductive bioregulator support.

Dosing Quick Reference

Testagen— Dosing Guide
Dose Range
10-20 mg/day (oral) or 1-2 mg SC
Half-Life
~30 minutes (estimated)
Frequency
1× daily for 10-30 day cycles
Route
Subcutaneous
5 mg vial10 mg vial
💧 2.5 mL BAC water📐 2 mg/mL concentration💉 20 mcg/unit (100u syringe)
Khavinson Bioregulatorcalcmypeptide.com

Frequently Asked Questions

Is Testagen a substitute for TRT?
No. TRT replaces testosterone with an exogenous source, which shuts down natural testicular production. Testagen is a bioregulator that signals your testes to restore their own natural production capacity, addressing aging at the cellular level without causing suppression.

References

  1. Khavinson VKh et al. "Short peptides stimulate testosterone production in aging".” Advances in Gerontology (2005). PMID: 16152864

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Recommended SourceOral Bioregulator

Get Testagen from Vita-Stream — the comprehensive distributor for authentic Khavinson bioregulators. Oral capsules, no injections required.

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