Thymogen
Thymogen (Glu-Trp) is a radically effective synthetic dipeptide commanding intense thymopoietic activity. A foundational cornerstone of Eastern European immune medicine, it is clinically deployed to rapidly reconstruct destroyed immune systems post-radiation, completely reverse medication-induced immunosuppression, and crush stubborn, entrenched chronic viral infections. Its microscopic size grants it immediate, devastating efficacy when administered intranasally or subcutaneously.
Quick Stats
Scientific Data
Mechanism of Action
Thymogen (Glu-Trp) is a synthetic dipeptide thymic bioregulator developed by Vladimir Khavinson. It restores T-cell differentiation, NK cell activity, and immune-endocrine balance. Clinical studies show improved immune response in elderly patients and reduced immune senescence markers.
Source: PMID: 15677927
Background & History
Thymogen (Glu-Trp, EW dipeptide) was developed at the Institute of Bioregulation and Gerontology in St. Petersburg as part of Professor Khavinson's peptide bioregulator program. It is distinguished from most bioregulators by its approval status — Thymogen is registered as a pharmaceutical product in the Russian Federation (registration number P N000313/01) and available as both an intranasal spray (25 mcg/dose, OTC) and injection (100 mcg/mL, prescription). It is one of the most widely used thymic immunomodulators in Russian clinical practice.
Research Use Cases
- ✓Secondary immunodeficiency (post-infection, post-surgery)
- ✓Chronic bacterial and viral infection adjunct
- ✓Post-radiation immune recovery
- ✓Seasonal immune support (cold/flu prevention)
Dosing Protocol
| Typical Dose | 100-1000 mcg/day (intranasal or SC) |
| Frequency | 1× daily for 3-10 days |
| Half-Life | ~20-30 minutes |
| Common Vial Sizes | 1 mg, 5 mg |
Dosing Protocols
Khavinson Protocol
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 100–1000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 77 mcg | 424 mcg | 771 mcg |
| 140 lb(63 kg) | 90 mcg | 495 mcg | 900 mcg |
| 160 lb(73 kg) | 104 mcg | 574 mcg | 1043 mcg |
| 180 lb(82 kg) | 117 mcg | 644 mcg | 1171 mcg |
| 200 lb(91 kg) | 130 mcg | 715 mcg | 1300 mcg |
| 220 lb(100 kg) | 143 mcg | 786 mcg | 1429 mcg |
| 250 lb(113 kg) | 161 mcg | 888 mcg | 1614 mcg |
💉 For exact syringe units based on your vial concentration, use the Thymogen Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Immune Senescence / T-Cell Immunity
LowThymic dipeptide. Restores T-cell and NK function. Khavinson protocol component.
Reconstitution Example
Safety & Considerations
Research peptide in Western markets. Extensively used in Russian clinical protocols. Excellent safety profile across decades of use in elderly populations.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Well tolerated. Intranasal spray form is OTC in Russia — excellent safety profile. Avoid in autoimmune conditions. Standard course: 3-10 days. Can be combined with conventional antibiotics/antivirals for infection management.
Synergies & Common Stacks
Thymogen (mild thymic dipeptide, OTC) can serve as maintenance therapy between Thymosin Alpha-1 cycles (more potent, prescription-level) — graduated immune support.
Thymogen stimulates thymulin production from thymic epithelial cells — the two peptides are mechanistically linked, with Thymogen acting upstream to enhance endogenous thymulin secretion.
Dosing Quick Reference
Frequently Asked Questions
How does Thymogen differ from Thymalin?▼
References
- Khavinson VKh et al. “"Thymic dipeptide Thymogen modulates neuroendocrine and immune function".” Bulletin of Experimental Biology and Medicine (1997). PMID: 9364573
📚 Related Articles
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