Healing & Recovery

Triptorelin

Trelstar · Decapeptyl · GnRH Agonist

Triptorelin is a D-Trp6 GnRH agonist. Depot products (Trelstar, Decapeptyl) are FDA-approved for prostate cancer and other indications via receptor desensitization. The research-chem 100 mcg “one-shot PCT defibrillator” is community practice, not a label, and a second dose can suppress the axis. This is a hormonal agonist with a razor-thin off-label margin, not a recovery peptide.

WADA (S4) - prohibited in sport at all times

Reviewed by CalcMyPeptide Editorial Team

·Last updated: August 2026·Evidence: Moderate·2 peer-reviewed citations

Typical research dose

100 mcg (single dose PCT)

Frequency

Single dose (PCT)

Half-life

~3 hours SC for the peptide; depot microspheres are weeks-to-months and are a different product

Common vials

0.1 mg

CAS

57773-63-4

Molecular weight

1311.45 g/mol

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Sexual / hormonal6.5/10
Depot triptorelin is an approved GnRH-agonist drug. Ceiling 9 for that indication. This leaf’s consumer use is 100 mcg PCT folklore, so the score is for “the analog is real,” haircut for the off-label one-shot protocol having no adequate RCT.

Compound card

Sequence: pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Class: GnRH agonist (D-Trp6); depot drug ≠ 100 mcg PCT shot
Formula: C64H82N18O13
Status: FDA-approved

Dose it

0.1 mg + 1 mL BAC water → 0.1 mg/mL · 100 mcg ≈ 100 units (U-100)

Open in calculator

How it works

Triptorelin is native GnRH with D-Trp at position 6. That substitution resists peptidases and makes a long agonist. Given continuously as a depot (Trelstar, Decapeptyl), it desensitizes pituitary GnRH receptors and suppresses gonadal steroids. That is an FDA-approved prostate-cancer mechanism, not a recovery peptide.

The research-chem story is the opposite shape: one 100 mcg SubQ “restart” after steroids. A single agonist pulse can dump LH. A second dose, or a misunderstood depot, can shut the axis down. Conn and Crowley 1991 (NEJM, PMID 1984190) is the analog review to read, not a PCT RCT. Native gonadorelin is the short peptide. Do not stack them as a defibrillator.

Source: PMID: 15483224

ONE 100 mcg research dose, or a labeled depot. Not both.

A second microdose can desensitize the axis. Depot cancer doses are a different product. This is not a daily peptide.

Goal context

One pulse vs a depot

The same analog stimulates, then suppresses, depending on duration of receptor occupancy. Depot = suppression. Microdose = a gamble on a single pulse. Mixing those mental models is how people stall recovery.

Not gonadorelin

Gonadorelin is native, minutes-class GnRH. Triptorelin is the long D-Trp6 analog. See the gonadorelin leaf for pumps and diagnostics.

Background & History

Triptorelin is D-Trp6 GnRH. Depot products (Trelstar, Decapeptyl) suppress gonadal steroids on purpose. The 100 mcg one-shot PCT protocol is community practice with a thin margin. A second dose can desensitize the axis. Native gonadorelin is the short peptide. Filed under recovery; physiology is HPG.

Research Use Cases

✓GnRH-agonist analog identity (depot vs microdose)
✓Not a gentle PCT or a daily peptide

Dosing

Phase	Dose	Frequency	Notes
Community PCT microdose (unlabeled)	100 mcg	ONE SC injection. Never repeated as a course.	Folklore. Follow-on SERM/hCG is a clinic protocol, not this page.
Labeled depot (Trelstar class)	mg-class IM depot	Weeks to months	Prostate cancer / gyn indications. Opposite job from PCT.

Administration

Route / form

Single SC injection for the microdose story. IM depot for the drug.

Timing

Any time for a one-shot. Do not schedule a series.

Empty stomach?

No - Food timing is not critical.

Timeline

Hours after 100 mcg

LH/FSH may surge. That is agonist pharmacology, not a guaranteed restart.

Days to weeks

If receptors desensitize, testosterone falls. That is the depot lesson arriving early.

Who it is for

Need the agonist analog identity

Moderate

This is D-Trp6 GnRH. Depot labels are real.

Need a gentle PCT

Low

Wrong tool. Margin for error is thin.

Reconstitution

Vial	Water	Concentration	Example dose
0.1 mg (100 mcg)	1.0 mL BAC	0.1 mg/mL	The entire vial is 100 mcg = 1.0 mL = 100 units. There is no “second draw.”

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Approved depots suppress gonadal steroids on purpose (hot flashes, bone, mood, metabolic). The 100 mcg shot can still be the start of that if repeated. Not a recovery peptide. Fertility and cancer care belong with specialists.

Regulatory & Legal Status

FDA Status (US)

Approved

FDA-approved as Trelstar® for prostate cancer; used off-label for PCT and gender-affirming care

WADA Status (2026)

Prohibited (S4)

Competitive athletes subject to anti-doping controls should not use Triptorelin.

Classification

Prescription Drug

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

Trelstar/Decapeptyl labels are chemical castration via desensitization. They are not a 100 mcg PCT insert.
PMID 1984190 is a 1991 analog review, not a triptorelin PCT trial. The previous PMID 1975842 on this leaf was the wrong number.
No adequate RCT that a single 100 mcg research-chem dose restores physiologic testosterone after AAS.
Miscategorized as recovery in this catalog. Physiology is HPG.

Verdict

Triptorelin is a cancer-class GnRH agonist. The 100 mcg one-shot PCT protocol is community practice with a thin margin. Do not take a second dose because the first “didn’t work,” and do not confuse a 0.1 mg research vial with Trelstar depot.

Interactions & Contraindications

Repeated or depot exposure suppresses LH/FSH. Antiandrogens interact with downstream testosterone. Not a SERM substitute RCT.

Synergies & Common Stacks

+ Gonadorelin →

Do not combine as a defibrillator. Pulse vs suppression are opposite chronic jobs.

Frequently Asked Questions

Why only one 100 mcg dose?▼

A pulse may stimulate. Occupancy that lingers desensitizes. A second “booster” is how people accidentally run a depot protocol with a research vial.

Is this safer than Clomid?▼

Different mechanism, thinner margin. Not a safety upgrade. Endocrinology owns PCT.

How do I reconstitute a 0.1 mg vial?▼

Add 1.0 mL BAC for 0.1 mg/mL. The whole milliliter is 100 mcg. Do not split it into a week of injections.

Is Trelstar the same thing?▼

Same analog class, different dose, duration, and label. Trelstar is a depot. This leaf’s 100 mcg story is not that insert.

Can I combine with gonadorelin?▼

That is a good way to confuse pulse with suppression. Pick a clinician protocol, not a stack name.

FDA-approved?▼

Depot products are. The 100 mcg PCT syringe is not.

Why is this under recovery?▼

Catalog history. The score is sexual/hormonal.

What paper should I actually read?▼

Conn & Crowley, NEJM 1991, PMID 1984190, on GnRH analogs. It is not a PCT trial.

References

Conn PM, Crowley WF Jr “Gonadotropin-releasing hormone and its analogues.” N Engl J Med (1991). PMID: 1984190
Carel JC, et al. “Triptorelin for treatment of central precocious puberty.” Pediatrics (2009). PMID: 19948620

Looking for a trusted source? See our recommended suppliers

Independently tested · COA-verified · Save 10% with our exclusive code

See suppliers →

← Back to Peptide Library