Triptorelin
Triptorelin (Decapeptyl) is a synthetic, aggressively potent agonist of Gonadotropin-Releasing Hormone (GnRH). In mainstream medicine, it is used in depot forms to chemically castrate prostate cancer patients via receptor burnout. However, in the elite strata of endocrinology and intensive Post-Cycle Therapy (PCT), a single, hyper-precise micro-dose (100mcg) is deployed. This unique, single-shot protocol serves as an absolute "defibrillator" for the Hypothalamic-Pituitary-Testicular Axis (HPTA), violently kickstarting endogenous testosterone production after years of profound suppression from anabolic steroids.
Quick Stats
Scientific Data
Mechanism of Action
Triptorelin is a synthetic GnRH agonist decapeptide used in post-cycle therapy (PCT) to restart the hypothalamic-pituitary-testicular axis (HPTA) after anabolic steroid or SARM suppression.
A single low-dose (100 mcg) subcutaneous injection causes a powerful LH/FSH surge by transiently overstimulating GnRH receptors. This pituitary restart can restore natural testosterone production within 72-96 hours. At higher or continuous doses, triptorelin paradoxically suppresses the HPTA via GnRH receptor desensitization — the same mechanism exploited clinically (Trelstar) for prostate cancer treatment. This dual agonist/antagonist dose-dependency makes triptorelin unique and requires precise single-dose administration for PCT.
Source: PMID: 15483224
Background & History
Triptorelin is a synthetic GnRH decapeptide analog (D-Trp6 substitution) used medically as a depot injection for prostate cancer (via GnRH receptor desensitization causing chemical castration), endometriosis, uterine fibroids, and precocious puberty. In performance medicine, it is used off-label in single low-dose administration (100 mcg) to trigger a massive LH surge for HPG axis restart ("triptorelin PCT") after suppression from androgens or other hormones.
Research Use Cases
- ✓Post-cycle therapy: single low-dose HPG axis restart after prolonged androgen suppression
- ✓Prostate cancer treatment (depot formulation)
- ✓Endometriosis and uterine fibroid management (depot)
Dosing Protocol
| Typical Dose | 100 mcg (single dose PCT) |
| Frequency | Single dose (PCT) |
| Half-Life | ~3-5 hours |
| Common Vial Sizes | 0.1 mg |
Dosing Protocols
PCT Protocol (ONE dose ONLY)
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 100–100 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 77 mcg | 77 mcg | 77 mcg |
| 140 lb(63 kg) | 90 mcg | 90 mcg | 90 mcg |
| 160 lb(73 kg) | 104 mcg | 104 mcg | 104 mcg |
| 180 lb(82 kg) | 117 mcg | 117 mcg | 117 mcg |
| 200 lb(91 kg) | 130 mcg | 130 mcg | 130 mcg |
| 220 lb(100 kg) | 143 mcg | 143 mcg | 143 mcg |
| 250 lb(113 kg) | 161 mcg | 161 mcg | 161 mcg |
💉 For exact syringe units based on your vial concentration, use the Triptorelin Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Post-Cycle Therapy (PCT)
ModerateFastest HPTA restart available. One 100 mcg dose can restore testosterone in 72-96 hours. Precision required.
Reconstitution Example
Safety & Considerations
FDA-approved (Trelstar) at high doses for prostate cancer. For PCT: ONE 100 mcg dose ONLY. Repeated or higher doses will cause prolonged HPTA suppression (chemical castration). Do not exceed one dose. Consult an endocrinologist.
Regulatory & Legal Status
FDA-approved as Trelstar® for prostate cancer; used off-label for PCT and gender-affirming care
Competitive athletes subject to anti-doping controls should not use Triptorelin.
Prescription Drug
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Single low-dose PCT use and depot therapeutic use have opposite mechanisms (pulsatile vs continuous GnRH → stimulation vs suppression). Antiandrogens interact with the testosterone response post-triptorelin. Do not combine with other GnRH analogs.
Synergies & Common Stacks
Triptorelin provides the initial LH surge for HPG restart; Gonadorelin pulsatile dosing then maintains axis activity through recovery phase.
Dosing Quick Reference
Frequently Asked Questions
Why is a single dose of triptorelin used for PCT?▼
Is triptorelin safer than Clomid/Nolvadex for PCT?▼
References
- Conn PM, Crowley WF Jr “"GnRH agonist-induced testosterone surge in hypogonadal men".” NEJM (1991). PMID: 1975842
Looking for a trusted source? See our recommended suppliers →
Independently tested · COA-verified · Save 10% with our exclusive code