Low-Dose Naltrexone (LDN) Online: Cost and What the Evidence Says
Low-dose naltrexone is naltrexone, an old opioid-blocking drug, prescribed off-label at 1.5 to 4.5 mg (the approved dose is 50 mg). Most LDN is compounded into small capsules. Generic 50 mg tablets cost $22.94 for 30 at Cost Plus Drugs; an online LDN plan with the prescription included runs $129 to $161 a month. The evidence is mixed, so here are both the prices and the trials.
By CalcMyPeptide Editorial · Published · Prices checked · How we rank
Prices checked · Written by the CalcMyPeptide editorial team · Medical review pending
Quick answer
- Generic naltrexone 50 mg (the FDA-approved tablet): $22.94 for 30 at Cost Plus Drugs plus $5.25 shipping; $50.79 at Costco (member price). Some prescribers have a pharmacist prepare low doses from it; do this only on their instructions.
- Compounded LDN capsules online: HealthRX, $129/mo on a 12-month plan up to $161 month-to-month (1.5–4.5 mg, provider visit and shipping included).
- Evidence: a small 2013 crossover trial in 31 women with fibromyalgia found less pain than placebo; a larger 2024 randomized trial in 99 women (6 mg) found no significant difference.
Naltrexone and LDN prices, cheapest first
| Seller | Product | Price | Status | Includes |
|---|---|---|---|---|
| Cost Plus Drugs | Generic naltrexone 50 mg, 30 tablets | $22.94 + $5.25 shippingseller's list price | FDA-approved generic | Medication only; you need your own prescription. Not a low-dose product as sold |
| Costco Pharmacy | Generic naltrexone 50 mg, 30 tablets | $50.79 (member price, warehouse pickup); $53.78 home deliveryseller's list price | FDA-approved generic | Medication only; you need your own prescription |
| HealthRX | Low-dose naltrexone 1.5–4.5 mg capsules, 30 | $129/mo (12-month), $137 (6-month), $145 (3-month), $161 (monthly)source | Compounded (not FDA-approved) | Medication, provider visit and unlimited follow-ups, free shipping; full refund if not approved |
Sorted by the lowest published monthly cost. "Starting at" prices can change after a clinician sets your dose. Linked brands are affiliate or applied-for programs (rel="sponsored"); other sellers are listed as plain text for price context only.
What the evidence shows
- Fibromyalgia, 2013: in a small double-blind crossover trial of 31 women, LDN 4.5 mg reduced daily pain more than placebo (Younger et al., Arthritis Rheum 2013).
- Fibromyalgia, 2024: in a randomized trial of 99 women, LDN 6 mg for 12 weeks was not superior to placebo for pain (between-group difference -0.34 points, p=0.27) (Due Bruun et al., Lancet Rheumatol 2024).
- Studies in other conditions are small or early. LDN is not FDA-approved for any off-label use.
How to pay the least
- Ask a clinician you already see; many will prescribe LDN and send it to a local compounding pharmacy at a lower cost than a subscription.
- Compare a full year: HealthRX’s 12-month plan is $1,548 versus $1,932 month-to-month.
- Avoid sellers who skip a clinician review; naltrexone interacts with opioids.
FAQ
How much does low-dose naltrexone cost?
Compounded LDN from HealthRX is $129 to $161 a month including the provider visit (checked Oct 7, 2026). The FDA-approved 50 mg generic tablet costs $22.94 for 30 at Cost Plus Drugs or $50.79 at Costco, with a prescription.
Is low-dose naltrexone FDA-approved?
No. Naltrexone is approved at 50 mg for alcohol and opioid dependence. Low doses for pain or inflammation are off-label, and the small capsules are compounded, which means they are not FDA-approved.
Does LDN work for fibromyalgia?
The evidence is mixed. A small 2013 trial found less pain than placebo, but a larger 2024 randomized trial at 6 mg found no significant difference. Talk to a clinician about whether a trial of LDN makes sense for you.
Related
Sources
Prices and product facts come from each seller's own pages, read Oct 7, 2026. We link only to sellers we have an affiliate relationship with and to government and research sources; other sellers' prices are quoted as plain text.
- HealthRX: Low-dose naltrexone 1.5–4.5 mg capsules, 30
- Younger et al., Arthritis Rheum 2013: LDN in fibromyalgia (PMID 23359310)
- Due Bruun et al., Lancet Rheumatol 2024: naltrexone 6 mg vs placebo in fibromyalgia (PMID 38258677)
- MedlinePlus: Naltrexone
- FDA: Compounding questions and answers
Also read for prices (not linked; no affiliate relationship): costplusdrugs.com, rx.costco.com.