Comparison
IGF-1 LR3 vs MK-677
Side-by-side attributes from our library comparison data. Read each peptide leaf for dosing math, regulatory status, and citations.
IGF-1 LR3 vs. MK-677
| Attribute | IGF-1 LR3 | MK-677 |
|---|---|---|
| Administration | Subcutaneous injection | Oral (daily) |
| Mechanism | Direct IGF-1 receptor agonist | Ghrelin receptor agonist → GH → IGF-1 |
| IGF-1 Elevation | Direct, immediate, strong | Indirect - GH stimulation cascade |
| Half-Life | 20–30 hours (LR3 modification) | 24-hour sustained oral action |
| Muscle Uptake | Direct muscle anabolic signaling | Systemic GH/IGF-1 elevation |
| WADA Status | Prohibited (S2) | Prohibited (S2) |
Verdict: IGF-1 LR3 offers direct, potent anabolic signaling at the receptor level - typically stronger for muscle hypertrophy than MK-677. However, MK-677 also provides GH itself (bone density, sleep, recovery) via the indirect GH cascade.