Khavinson BioregulatorTarget: Bone marrowImmune

Bonomarlot

Bonomarlot A-20 · Bone Marrow Cytomax · A-20 Bioregulator · Бономарлот

Bonomarlot is the Cytomax bone-marrow complex. It is the hematopoietic-tissue counterpart to the thymic immune SKUs - marrow as the factory, thymus as the finishing school. It is not a G-CSF biosimilar and not chemotherapy rescue.

Not FDA-approved - research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: August 2026Evidence: Low6 peer-reviewed citations
Typical research dose
1-2 capsules/day
Frequency
1-2× daily for 10-30 day cycles
Half-life
Variable (oral peptides absorbed via GI tract)
Common vials
N/A (oral)
CAS
N/A (biological extract, not a single compound)
Molecular weight
Mixture (<5 kDa, short-chain di- and tripeptides)

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Longevity / aging3.5/10

    Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.

  • Immune3.5/10

    Thymus/immune organ map in the school. Not Zadaxin and not a US immune-deficiency drug.

Compound card

Sequence
Bone marrow peptide complex (mixture, not a single CAS)
Class
Khavinson Cytomax capsule complex (Bone marrow)
Formula
Polypeptide extract (Bone Marrow tissue, <5 kDa)
Status
Not FDA-approved · research use

How it works

Bonomarlot (A-20) is a natural Cytomax - a purified polypeptide complex extracted from the bone marrow tissue of young calves using Professor Vladimir Khavinson's patented low-temperature filtration process. The resulting short-chain peptides (under 5 kDa, free of any DNA fragments or immunogenic material) act as tissue-specific epigenetic regulators for the hematopoietic system.

**How It Works at the Cellular Level** Bone marrow is the body's blood cell factory - throughout your life it produces red blood cells (oxygen transport), white blood cells (immunity), and platelets (clotting) on demand. After age 35–40, this output begins declining measurably. By age 60, hematopoietic stem cell activity and bone marrow reserve can drop by 30–50%, contributing to immunosenescence, fatigue, and anemia.

Bonomarlot's peptides penetrate hematopoietic stem cell and stromal cell nuclei, binding to specific chromatin regions to unwind heterochromatin and re-activate gene promoters that have been progressively silenced by epigenetic aging. The result is restoration of normal protein synthesis in bone marrow precursor cells - effectively reversing key aspects of age-related marrow decline without introducing exogenous hormones or synthetic molecules.

**Known Peptide Stack Roles** Khavinson's clinical protocols recommend Bonomarlot in what he calls the "body detox" stack (A-6 Vladonix + A-7 Svetinorm + A-8 Endoluten + A-20 Bonomarlot), targeting full immune and metabolic restoration. It is also included in respiratory, locomotor, and recovery-focused stacks.

**How Cytomaxes Differ from Synthesized Peptides** Synthesized peptides like Crystagen target a single molecular pathway and produce rapid, intense effects lasting 1.5–2 months. Cytomaxes like Bonomarlot contain a spectrum of related peptide molecules that work more gradually, producing effects that accumulate over months and persist long after the course ends - often 4–6 months of benefit from one 30-day protocol.

Source: PMID: 12677266

Khavinson map

Canonical 41
Class
Cytomax (natural peptide complex)
Organ
Bone marrow
Target
Bone marrow
System
Immune
Sequence
Mixture / not a single CAS
Pair
Immune cytogens (Crystagen / Vilon) - marrow is the upstream hematopoietic bed
Бономарлот

Used in bioregulator stacks

Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.

The Khavinson school

Vladimir Khatskelevich Khavinson (1946–2024) spent five decades at what became the St. Petersburg Institute of Bioregulation and Gerontology arguing a simple, stubborn idea: aging is, in part, a failure of tissue-specific peptide signals, and those signals can be restored. The first products were not “peptides” in the Instagram sense. They were Cytamins - polypeptide fractions isolated from a named organ of young animals. Later commercial refinements of those fractions are sold as Cytomaxes (Cytomed / NPCRIZ): still mixtures, still oral capsules, still defined by the source organ rather than a single sequence. When the group identified short active motifs inside those mixtures, they synthesized them as Cytogens - di-, tri-, and tetrapeptides with a one-letter code (KE, AEDG, KED, EDR, KEDP, and so on).

That three-layer stack is the whole map. Cytamin / pharmaceutical extracts (Thymalin, Epithalamin, Cortexin, Retinalamin, Prostatilen) are the clinic-era injectables registered in the former Soviet pharmacopeia. Cytomaxes are the capsule complexes Cytomed still lists as a 21-SKU organ line. Cytogens are the defined synthetics. English-language educators, including Brenden Henry’s public writing at Peptide Science Institute, add a further commercial distinction - later analog SKUs (N-acetyl, amidate, “V2” complexes) sold as more stable or more diverse than the original Cytomed lots. That last layer is a product taxonomy, not a Khavinson paper. We describe it so readers are not gaslit by three bottles with the same organ name. We do not reproduce paid Peptide Mastery protocols, Precision Cell Method language, or anyone else’s course IP.

Full Cytamin → Cytomax → Cytogen map, literature limits, and how we counted 41

The mechanism Khavinson published is epigenetic, not receptor-agonist in the GLP-1 sense. Short peptides are claimed to enter nuclei, interact with DNA/histones, and reopen tissue-specific transcription that condensed with age (heterochromatin → euchromatin). Reviews in the Bulletin of Experimental Biology and Medicine and Neuroendocrinology Letters (PMID 14523363, 15677927, 23888677) are the citable core. Complementary GI pharmacology is not mystical: di- and tripeptides are PEPT1/LAT substrates, which is why oral capsules are even a conversation. What is not established in Western Phase 3 programs is organ-by-organ disease treatment, telomere reversal as a clinical endpoint, or the manufacturer claim that Cytomax is “a third stronger” than Cytogen. Those are NPCRIZ marketing sentences.

Khavinson’s group published hundreds of papers, many in Russian, many in the same journal family. That is a real literature. It is also a literature with limited independent Western replication, small n, and a habit of using one review PMID as a stamp on every organ. On this site a leaf earns its organ story, its Cytomax↔Cytogen pair, its sequence if it has one, and an honest sentence about what has not been shown. Reconstitution math belongs on cytogens sold as vials. Cytomax capsules do not get a fake 5 mg vial.

The 41 we treat as canonical are the 21 Cytomaxes on the public e-peptide/Cytomed list, the 12 Cytogens on that same commercial line (including Vesilut, which Western catalogs often drop), plus eight historically load-bearing molecules that sit beside the capsule SKUs: Epitalon, Vilon, Thymogen, Livagen, Cortagen, Prostamax, Thymalin, and Epithalamin. Honluten, Cortexin, Retinalamin, Prostatilen, Thymulin, N-acetyl-epitalon-amidate, Pinalex, and the GPL Man / GPL Femme kits are covered as adjacent - same school or same storefront, not padded into a fake 41.

Public English-language teaching (including Brenden Henry at peptidescienceinstitute.com) is cited as context, not copied. Paid Peptide Mastery / Peptide Salvation text stays theirs.

History of this molecule

Bone marrow as a Khavinson target is the least Instagram-friendly and the most historically Soviet: radiation, cytopenias, occupational exposure. The extract logic is that marrow stroma and hematopoietic islands have peptide signals that age or burn out, and a tissue fraction might restore transcription in those cells.

Bonomarlot is easy to overclaim. Filgrastim raises neutrophils on a known receptor. This capsule does not. Pairing it with Vladonix (thymus) is the school’s own “factory + education” metaphor. Pairing it with random “blood builder” supplements is not.

There is no clean single cytogen named “marrow-only” on the 12-SKU NPCRIZ cytogen list the way Pancragen is pancreas-only. Immune cytogens (Crystagen, Vilon) are the synthetic neighbors, not a perfect 1:1.

Caveats

Bone marrow Cytomax is not a US dietary-supplement monograph and not a drug. The tissue-extract model means lot-to-lot composition is a fingerprint, not a single CAS number. English-language “V2” bottles that claim more peptide diversity are a later commercial layer (mass-spec marketing from specific brands) - they are not Khavinson’s 1990s papers. Animal-source capsules are inappropriate if the reader has a religious or allergy constraint on the source species. None of this replaces care for the actual organ disease. Unexplained cytopenia is a workup, not a capsule.

Full 41-map: Khavinson bioregulators index · Bioregulator stacks

Research Use Cases

  • ✓Bone Marrow / Hematopoietic Health: High
  • ✓Immune System Support: Moderate
  • ✓Post-Chemotherapy Recovery: Moderate
  • ✓General Longevity / Anti-Aging: Moderate

Dosing

PhaseDoseFrequencyNotes
Mini-Course / General Preventive (1 box)2 capsules (20 mg)Once daily for 10 days (20 caps total = 1 box)Per Vita-Stream/Khavinson protocol: the standard mini-course. For general support, repeat every 6 months. If greater support is needed, repeat every 2–3 months. Take 30 minutes before meals.
Full Monthly Course (ages 40–50)2 capsules (20 mg)Twice daily for 30 days (120 caps total = 2× 60-cap boxes)Full 30-day bi-annual course recommended from age 40–45. After 50, consider 3 courses/year. Often combined with Vladonix (A-6, thymus) and Ventfort (A-3, blood vessels) for complete immune-cardiovascular axis support. Take 30 minutes before meals (morning + evening doses).
Intensive / High-Need Protocol2 capsules (20 mg)Twice daily, repeated monthly as neededFor significant immune decline, post-illness recovery, or oncology support contexts (physician supervision required). Combine with Endoluten (A-8) and Svetinorm (A-7) for the full "body detox" stack. Maximum recommended: 4 capsules/day (40 mg).

Administration

Route / form
Oral capsules - swallowed with water. Cytomed Cytomaxes ship as capsules, not sublingual tablets and not lyophilized research vials.
Timing
Morning, with water, about 30 minutes before meals (empty stomach).
Empty stomach?
Yes - Empty stomach - about 30 minutes before meals. Cytomed boxes sometimes print “with food” because they are labeled as supplements; the manufacturer user-guide preference is before meals for absorption.

Bonomarlot: Not a research vial vs Oral capsule

Not a research vial
Bioavailability
Not applicable. This Cytomax SKU is not sold as a lyophilized research vial. There is no SubQ F% because Cytomed does not ship this complex as a cake.
Dose note
Do not reconstitute Bonomarlot. No BAC-water chart, no 5 mg vial math, no units-on-a-U-100 conversion. No dedicated cytogen on the 12-SKU NPCRIZ poster. Nearest synthetic neighbors: Vilon / Crystagen (immune cytogens; marrow is the upstream bed). Do not invent a missing cytogen. There is no pharmaceutical-extract SKU that is this capsule in a syringe.
Advantages
  • No dedicated cytogen on the 12-SKU NPCRIZ poster. Nearest synthetic neighbors: Vilon / Crystagen (immune cytogens; marrow is the upstream bed). Do not invent a missing cytogen.
  • There is no pharmaceutical-extract SKU that is this capsule in a syringe.
  • NPCRIZ does not list a marrow-only cytogen on the 12-SKU poster. Do not relabel a 5 mg cake as Bonomarlot. Immune cytogens are the nearest synthetics.
Considerations
  • Bonomarlot is an oral capsule complex. It is not a 5 mg lyophilized research vial.
  • Inventing recon math for a zero-mg Cytomax vial is how people inject the wrong product.
  • Not an official Cytomed sublingual tablet, IM ampoule, or eye drop either.
Oral capsule
Bioavailability
Not quantified in a Western PK study. Official Cytomed form is a swallowed capsule. PEPT1/LAT transport is class biology for short peptides, not an F% for this tissue mixture.
Dose note
Typical Cytomed labeling: 1–2 capsules daily in 10–30 day courses, swallowed with water about 30 minutes before meals (empty stomach). Manufacturer protocol, not an FDA label. Some boxes print “with food” because they are labeled as supplements; the timing copy we use is before meals.
Advantages
  • Official form for Bonomarlot: swallow the capsule with water. No reconstitution step and no 5 mg cake.
  • Bone-marrow Cytomax (Cytomed A-20): hematopoietic-tissue complex. Not a G-CSF biosimilar and not chemotherapy rescue.
  • Course-based (10–30 days, a few times a year in manufacturer folklore), not a daily forever drug.
Considerations
  • Bone marrow Cytomax is a peptide mixture / lot fingerprint, not a single CAS. English “V2” bottles are a later commercial layer, not a Khavinson RCT.
  • Russian school literature is not an FDA organ-disease label.
  • Third-party lingual SKUs exist in the wild. We do not claim sublingual as the official Cytomed Cytomax form.
Recommendation: Swallow Bonomarlot as oral capsules with water, about 30 minutes before meals. Bone-marrow Cytomax complex, not a research vial and not filgrastim. No dedicated marrow cytogen on the 12-SKU poster; nearest synthetics are Vilon / Crystagen. Unexplained cytopenia is a workup, not a capsule.

Timeline

Days 1–7
Peptides begin binding to hematopoietic stem cell chromatin; initial gene expression shifts noted in preclinical studies.
Weeks 2–4 (during course)
Normalization of bone marrow protein synthesis profile underway. Users report improved energy and immune vitality.
Months 1–3 (post-course)
Peak hematopoietic output benefit; CBC values may show improved RBC, WBC, and platelet counts if baseline deficits existed.
Months 3–6
Sustained immunological benefit. Long-lasting epigenetic changes persist well beyond the supplementation window, per Khavinson's longitudinal data.

Who it is for

Bone Marrow / Hematopoietic Health

High

Primary target organ. Supports red and white blood cell precursor production. Relevant for age-related anemia, immune decline, and bone marrow fatigue.

Immune System Support

Moderate

Bone marrow is the source of all immune cell precursors. Bonomarlot supports the upstream factory for lymphocytes, monocytes, and granulocytes.

Post-Chemotherapy Recovery

Moderate

Khavinson's protocols have been used in Russian oncology support contexts for marrow recovery after cytotoxic treatment. Consult physician.

General Longevity / Anti-Aging

Moderate

Part of Khavinson's core anti-aging stack. Bone marrow decline is a key driver of systemic aging; Bonomarlot addresses this upstream.

Athletic Recovery & Endurance

Low

Better RBC production can improve oxygen carrying capacity. Some endurance athletes use hematopoietic support for altitude training recovery.

Safety & Considerations

Bonomarlot is a bovine bone-marrow Cytomax complex. Russian clinic history is not a US safety NDA. Manufacturer copy that it contains “no immunogenic or mutagenic material” because of <5 kDa filtration is a process claim, not an immunogenicity study we will stamp as fact. Contraindications per manufacturer: individual intolerance of components, pregnancy, and lactation. If you are in active cancer care or on immunosuppressants, this page is not your protocol. Storage: Keep in a dry, dark place between +2°C and +25°C. Do not freeze.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • Cytomax SKUs are oral capsules. Do not run SubQ reconstitution math on a zero-mg vial.
  • Lot-to-lot composition is a fingerprint, not one sequence.
  • This site will not treat the named organ disease from a peptide page.
  • English-language V2 / analog bottles are a later commercial layer, not a Khavinson RCT.

Verdict

Bonomarlot is a Cytomax capsule complex from Bone marrow. It is not the paired cytogen, not a 5 mg research cake, and not a US supplement monograph. The organ story is in the dossier on this page.

Interactions & Contraindications

Bonomarlot is a bovine bone-marrow Cytomax complex. Russian clinic history is not a US safety NDA. Manufacturer copy that it contains “no immunogenic or mutagenic material” because of <5 kDa filtration is a process claim, not an immunogenicity study we will stamp as fact. Contraindications per manufacturer: individual intolerance of components, pregnancy, and lactation. If you are in active cancer care or on immunosuppressants, this page is not your protocol. Storage: Keep in a dry, dark place between +2°C and +25°C. Do not freeze.

Appears in goal guides

Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.

Anti-Aging Longevity Stack

Golden Triangle (Endoluten, Vladonix, Bonomarlot) plus Epitalon and GHK-Cu, with FOXO4-DRI and MOTS-c as experimental add-ons.

View Protocol →

Immune Optimization Protocol

Thymic cytomax (Vladonix) plus Endoluten and Bonomarlot, then Thymosin Alpha-1 and Selank, with LL-37/KPV as acute experimental tools.

View Protocol →

Frequently Asked Questions

Oral capsule or injection?▼
Bonomarlot is a Cytomax oral capsule: swallow with water, about 30 minutes before meals. It is not a 5 mg lyophilized research vial and not an official Cytomed sublingual tablet (third-party lingual SKUs exist in the wild). If you want a defined-sequence powder to reconstitute, that is the cytogen pair (none on the 12-SKU poster; nearest synthetics are Vilon / Crystagen), not this complex. Do not run BAC math on a capsule SKU.
Is Bonomarlot a blood-cancer treatment?▼
No. It is a tissue-extract capsule in a gerontology product line. Leukemia and aplastic anemia are specialist diseases.
What is the synthetic pair?▼
NPCRIZ does not list a dedicated marrow cytogen on the 12-SKU cytogen poster. Immune cytogens are the nearest synthetic neighbors.
Radiation origin story - is that a trial?▼
It is the Institute’s historical framing. It is not your personal dosimetry protocol.
Stack with Vladonix?▼
Marrow complex + thymus complex is the in-school pairing. Two complexes of adjacent immune tissues, not eight bottles.
What is Bonomarlot A-20 and what does it do?▼
Bonomarlot (A-20) is a natural peptide bioregulator derived from the bone marrow of young calves. It contains a complex of short peptides (<5 kDa) developed by Professor Vladimir Khavinson. It is designed to support the structural and functional health of bone marrow - the body's blood cell factory - helping maintain hematopoietic balance and immune resilience as we age.
Who should consider Bonomarlot?▼
Bonomarlot is most relevant for: (1) individuals over 40–50 experiencing age-related immune decline or fatigue; (2) those using it as part of a comprehensive anti-aging Cytomax stack; (3) people recovering from conditions that stress bone marrow (illness, heavy infections, cytotoxic therapies - but always physician-supervised for this use); (4) endurance athletes or high performers looking to support optimal blood cell production.
What peptides does Bonomarlot combine well with?▼
Per Khavinson's published protocols: for immune and detox support, pair with Vladonix (A-6, thymus), Svetinorm (A-7, liver), and Endoluten (A-8, neuro-endocrine). For cardiovascular support, add Ventfort (A-3, blood vessels). For locomotor recovery, add Sigumir (A-4, cartilage/bone). You can safely take up to 5 Cytomaxes simultaneously.
Does Bonomarlot contain actual bone marrow extract or hormones?▼
No hormones. Bonomarlot contains short-chain peptides (<5 kDa) extracted from bone marrow via patented cold filtration. This process removes DNA fragments, prions, and any immunogenic material. The result is a clean, targeted peptide complex - not a glandular supplement in the traditional sense, and completely distinct from erythropoietin or any growth factor.
How many capsules are in a box and how long does it last?▼
Bonomarlot is available in 20-capsule or 60-capsule boxes. At the standard 2 capsules/day protocol, a 20-capsule box = 10-day mini-course; a 60-capsule box = a full 30-day course. Khavinson recommends 2–3 full courses per year.

References

  1. Khavinson VKh et al. “Tissue-specific effects of peptides.” Bulletin of Experimental Biology and Medicine (2005). PMID: 15677927
  2. Khavinson VKh, Lin’kova NS, Tarnovskaya SI “Short peptides regulate gene expression.” Bulletin of Experimental Biology and Medicine (2013). PMID: 23888677
  3. Khavinson VKh, Morozov VG “Peptide regulation of aging: from experimental studies to clinical practice.” Advances in Gerontology (2003). PMID: 14523363
  4. Khavinson VKh “"Peptide bioregulators - a new class of geroprotectors".” Bulletin of Experimental Biology and Medicine (2002). PMID: 12677266
  5. Khavinson VKh, Anisimov VN “"Peptide regulation of aging".” Rejuvenation Research (2007). PMID: 17516852
  6. Khavinson VK, Morozov VG “"Regulatory peptides and the aging process".” Neuroendocrinology Letters (2003). PMID: 14618157

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