Crystagen
Crystagen (Glu-Asp-Pro) is a deeply restorative, synthetic Khavinson tripeptide bioregulator that serves as a broad-spectrum epigenetic architect for the entire systemic immune network. While Vilon targets the thymus specifically, Crystagen acts on the broader landscape of immunocompetent cells across the bone marrow and spleen. In elite longevity protocols, it is utilized to forcefully re-calibrate an exhausted immune system after severe viral insult, chronic autoimmune exhaustion, or catastrophic radiation exposure.
Quick Stats
Scientific Data
Mechanism of Action
Crystagen (Lys-Glu-Asp) is a tripeptide bioregulator targeting colonic mucosa and intestinal epithelial gene expression. It restores intestinal epithelial renewal, promotes gut mucosal regeneration, and normalizes bowel function in aging-related intestinal decline. Khavinson studies demonstrate improved intestinal motility, absorption, and mucosal integrity.
Source: PMID: 12677266
Background & History
Crystagen (Glu-Asp-Pro) is the broad-spectrum immune bioregulator in Khavinson's system, complementing thymus-specific Vilon. It modulates both innate and adaptive immunity.
Research Use Cases
- ✓Broad immune restoration
- ✓NK cell and macrophage activation
- ✓Immune normalization in chronic infection
- ✓Complement to Vilon in comprehensive immune protocols
Dosing Protocol
| Typical Dose | 10-20 mg/day (oral) or 1-2 mg SC |
| Frequency | 1× daily for 10-30 day cycles |
| Half-Life | ~30 minutes (estimated) |
| Common Vial Sizes | 5 mg, 10 mg |
Dosing Protocols
Khavinson Protocol
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 1000–20000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 771 mcg | 8100 mcg | 15429 mcg |
| 140 lb(63 kg) | 900 mcg | 9450 mcg | 18000 mcg |
| 160 lb(73 kg) | 1043 mcg | 10950 mcg | 20857 mcg |
| 180 lb(82 kg) | 1171 mcg | 12300 mcg | 23429 mcg |
| 200 lb(91 kg) | 1300 mcg | 13650 mcg | 26000 mcg |
| 220 lb(100 kg) | 1429 mcg | 15000 mcg | 28571 mcg |
| 250 lb(113 kg) | 1614 mcg | 16950 mcg | 32286 mcg |
💉 For exact syringe units based on your vial concentration, use the Crystagen Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Intestinal Aging / Gut Health
LowColon/intestinal bioregulator. Restores colonic epithelial gene expression in aging GI tract.
Reconstitution Example
Safety & Considerations
Research peptide. Extensively used in Russian clinical protocols. Excellent safety profile in elderly populations.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Avoid in autoimmune conditions. Standard Khavinson cycling protocol.
Synergies & Common Stacks
Crystagen (broad immune) + Vilon (thymus-specific) = comprehensive immune restoration targeting both innate/adaptive immunity and T-cell maturation.
Dosing Quick Reference
Frequently Asked Questions
What does Crystagen do for the gut?▼
References
- Khavinson VKh et al. “"Khavinson tissue-specific peptide bioregulators for aging".” Bulletin of Experimental Biology and Medicine (2009). PMID: 19503960
📚 Related Articles
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