CalcMyPeptide
Khavinson BioregulatorAlso known as: Ala-Glu-Asp-Arg, AEDR, Heart Bioregulator

Cardiogen

Cardiogen (Ala-Glu-Asp-Arg) is a potent Khavinson tetrapeptide bioregulator developed for absolute cardioprotection and high-stakes myocardial recovery. Frequently utilized in cardiac rehabilitation, it serves as the foundation for reversing age-related heart failure, rapidly accelerating recovery following a catastrophic myocardial infarction, and shielding elite athletes from the extreme cardiac stress induced by intensive hypertrophy protocols.

Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Low1 peer-reviewed citation

Quick Stats

Half-LifeShort (tetrapeptide)
Dose Range10-20 mg/day (oral) or 1-2 mg SC
Frequency1× daily for 10-30 day cycles
Vial Sizes5 mg, 10 mg
BioavailabilitySublingual or subcutaneous injection
Year Developed1990s

Scientific Data

Molecular Formula
C18H31N9O9
Molecular Weight
517.5 g/mol
CAS Number
PubChem ID

Mechanism of Action

Cardiogen (Ala-Glu-Asp-Arg) is a tetrapeptide bioregulator targeting myocardium (heart muscle). It stimulates the proliferation and differentiation of myocardial cells and restores expression of cardiac-specific proteins. Khavinson research demonstrates improvements in cellular metabolism of cardiomyocytes, reduced hypertrophy, and enhanced recovery following ischemia or myocardial infarction.

Source: PMID: 15677927

Background & History

Cardiogen (AEDR) targets cardiomyocytes for cardiac tissue resilience.

Research Use Cases

  • Cardiac tissue support in aging
  • Post-infarction recovery protocols
  • Cardiovascular health maintenance

Dosing Protocol

Typical Dose10-20 mg/day (oral) or 1-2 mg SC
Frequency1× daily for 10-30 day cycles
Half-Life~30 minutes (estimated)
Common Vial Sizes5 mg, 10 mg

Dosing Protocols

Khavinson Protocol

Dose
10 - 20 mg
Frequency
Daily SubQ for 10 days, 1-2x per year
Note: Cardiac bioregulator course. Often paired with Vesugen (vascular).

Body-Weight Dosing Reference

Estimated doses extrapolated from the published research range of 100020000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.

WeightLowTargetHigh
120 lb(54 kg)771 mcg8100 mcg15429 mcg
140 lb(63 kg)900 mcg9450 mcg18000 mcg
160 lb(73 kg)1043 mcg10950 mcg20857 mcg
180 lb(82 kg)1171 mcg12300 mcg23429 mcg
200 lb(91 kg)1300 mcg13650 mcg26000 mcg
220 lb(100 kg)1429 mcg15000 mcg28571 mcg
250 lb(113 kg)1614 mcg16950 mcg32286 mcg

💉 For exact syringe units based on your vial concentration, use the Cardiogen Reconstitution Calculator →

Administration

Route
Sublingual tablets or subcutaneous injection
Timing
Morning.
Fasting Required?
No — food timing not critical

Expected Timeline

Day 1-10 (course)
Cardiomyocyte gene expression restoration initiated.
Month 3-6
Improved cardiac function markers and stress tolerance with repeat courses.

Who Is It For?

Cardiac / Heart Aging

Low

Myocardial bioregulator. Targets age-suppressed cardiac gene expression.

Reconstitution Example

Vial
5 mg
Water
2.5 mL
Concentration
2 mg/mL
Per Unit (100u syringe)
20 mcg
Dose of 1000 mcg = 50 units on a 100-unit insulin syringe

Safety & Considerations

Research peptide. Extensively used in Russian clinical protocols. Excellent safety profile in elderly populations.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Interactions & Contraindications

Standard Khavinson protocol.

Synergies & Common Stacks

Cardiogen (synthetic) + Chelohart (cardiac Cytomax) = layered cardiac bioregulator support.

Cardiogen (heart muscle) + Vesugen (vascular endothelium) = comprehensive cardiovascular protocol.

Dosing Quick Reference

Cardiogen— Dosing Guide
Dose Range
10-20 mg/day (oral) or 1-2 mg SC
Half-Life
~30 minutes (estimated)
Frequency
1× daily for 10-30 day cycles
Route
Subcutaneous
5 mg vial10 mg vial
💧 2.5 mL BAC water📐 2 mg/mL concentration💉 20 mcg/unit (100u syringe)
Khavinson Bioregulatorcalcmypeptide.com

Frequently Asked Questions

How does Cardiogen differ from Chelohart?
Cardiogen is a specific synthetic tetrapeptide (AEAD), while Chelohart is a Cytomax — a broader polypeptide extract derived from animal heart tissue. Cardiogen provides targeted signaling, whereas extracts provide a wider spectrum of cardiac peptides.

References

  1. Khavinson VKh et al. "Cardiogen stimulates proliferation of myocardial cells".” Bulletin of Experimental Biology and Medicine (2009). PMID: 19702220

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Recommended SourceOral Bioregulator

Get Cardiogen from Vita-Stream — the comprehensive distributor for authentic Khavinson bioregulators. Oral capsules, no injections required.

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