Cortagen
Cortagen (Ala-Glu-Asp-Pro) is a hyper-targeted, synthetic Khavinson tetrapeptide bioregulator designed strictly for the profound epigenetic modulation of the cerebral cortex. Favored in aggressive neuro-recovery protocols, it operates as a molecular command code to reverse devastating neurological trauma. It is clinically deployed to abruptly halt cognitive decay, violently accelerate recovery following severe ischemic strokes, and upregulate the brain’s endogenous antioxidant defense grid against catastrophic oxidative aging.
Quick Stats
Scientific Data
Mechanism of Action
Cortagen (Ala-Glu-Asp-Pro) is a tetrapeptide bioregulator targeting cerebral cortex and neuronal gene expression. It promotes neuronal transcription restoration, improves cognitive function, and provides neuroprotection via gene regulatory mechanisms in cerebral cortex tissue. Khavinson studies show improvements in cognitive function, memory, and neurological recovery.
Source: PMID: 18402693
Background & History
Cortagen (Ala-Glu-Asp-Pro) targets brain cortex neurons — part of Khavinson's CNS bioregulator triad alongside Pinealon (pineal) and Cerluten (brain extract). Animal studies showed 30-40% reduction in experimental stroke infarct volume.
Research Use Cases
- ✓Neuroprotection
- ✓Cognitive support in aging
- ✓Post-stroke recovery
- ✓Neurodegenerative disease prevention
Dosing Protocol
| Typical Dose | 10-20 mg/day (oral/nasal) or 1-2 mg SC |
| Frequency | 1× daily for 10-30 day cycles |
| Half-Life | ~30 minutes (estimated) |
| Common Vial Sizes | 5 mg, 10 mg |
Dosing Protocols
Khavinson Protocol
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 1000–20000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 771 mcg | 8100 mcg | 15429 mcg |
| 140 lb(63 kg) | 900 mcg | 9450 mcg | 18000 mcg |
| 160 lb(73 kg) | 1043 mcg | 10950 mcg | 20857 mcg |
| 180 lb(82 kg) | 1171 mcg | 12300 mcg | 23429 mcg |
| 200 lb(91 kg) | 1300 mcg | 13650 mcg | 26000 mcg |
| 220 lb(100 kg) | 1429 mcg | 15000 mcg | 28571 mcg |
| 250 lb(113 kg) | 1614 mcg | 16950 mcg | 32286 mcg |
💉 For exact syringe units based on your vial concentration, use the Cortagen Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Cognitive Aging / Neuroprotection
LowCerebral cortex bioregulator. Restores neuronal gene expression suppressed by aging.
Reconstitution Example
Safety & Considerations
Research peptide. Extensively used in Russian clinical protocols. Excellent safety profile in elderly populations.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
Standard Khavinson protocol. Compatible with most other bioregulators and nootropic peptides.
Synergies & Common Stacks
Cortagen (cortical neurons) + Pinealon (pineal gland) = comprehensive CNS bioregulator support for both daytime cognition and sleep/circadian function.
Cortagen (synthetic tetrapeptide) + Cerluten (brain Cytomax extract) = layered CNS support through targeted + broad-spectrum peptide approaches.
Dosing Quick Reference
Frequently Asked Questions
What does Cortagen target in the brain?▼
References
- Khavinson VKh et al. “"Short peptide bioregulators restore gene expression in aging cerebral cortex".” Bulletin of Experimental Biology and Medicine (2009). PMID: 19503960
📚 Related Articles
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