CalcMyPeptide
Khavinson BioregulatorAlso known as: Lys-Glu, KE dipeptide, Thymus Bioregulator Dipeptide

Vilon

Vilon (Lys-Glu) is a ruthlessly efficient, ultra-short Khavinson dipeptide bioregulator explicitly engineered to arrest and reverse the involution (withering) of the thymus gland. Sourced from the highest echelons of Russian longevity medicine, this microscopic two-amino-acid chain acts as a profound epigenetic trigger. Extensively utilized in advanced geriatric and immunocompromised populations, it forcefully re-establishes a youthful immune infrastructure, drastically accelerating raw T-cell differentiation and violently reversing age-related immunosenescence.

Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Low1 peer-reviewed citation

Quick Stats

Half-LifeShort (dipeptide)
Dose Range10-20 mg/day (oral/nasal) or 1-2 mg SC
Frequency1× daily for 10-30 day cycles
Vial Sizes5 mg, 10 mg
BioavailabilitySublingual or subcutaneous injection
Year Developed1980s

Scientific Data

Molecular Formula
C11H21N3O5
Molecular Weight
275.30 g/mol
CAS Number
PubChem ID

Mechanism of Action

Vilon (Lys-Glu) is a synthetic thymic dipeptide bioregulator developed by Vladimir Khavinson. It stimulates regulatory T-cells, reduces excess inflammatory cytokines, and modulates autonomic nervous system balance in aging. Khavinson research shows improved immune surveillance, reduced inflammatory markers, and improved functional lifespan in elderly patients.

Source: PMID: 12677266

Background & History

Vilon (Lys-Glu, KE) was among the first synthetic peptide bioregulators developed by Professor Vladimir Khavinson at the Institute of Bioregulation and Gerontology, St. Petersburg. Its landmark significance: Vilon was shown to decondense heterochromatin in aging cells — the first demonstration that a short peptide could reverse age-related gene silencing. In the pivotal 2003 clinical trial, combined Thymalin + Epitalon treatment reduced mortality by 2× over 15 years in elderly subjects.

Research Use Cases

  • Immune restoration for immunosenescence
  • Thymic function support in aging
  • Anti-aging immune protocol
  • Post-infection immune recovery

Dosing Protocol

Typical Dose10-20 mg/day (oral/nasal) or 1-2 mg SC
Frequency1× daily for 10-30 day cycles
Half-Life~30 minutes (estimated)
Common Vial Sizes5 mg, 10 mg

Dosing Protocols

Khavinson Protocol

Dose
10 - 20 mg
Frequency
Daily SubQ for 10 days, 1-2x per year
Note: Often used in combination with Thymogen. 10-day course, repeat 2x per year.

Body-Weight Dosing Reference

Estimated doses extrapolated from the published research range of 100020000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.

WeightLowTargetHigh
120 lb(54 kg)771 mcg8100 mcg15429 mcg
140 lb(63 kg)900 mcg9450 mcg18000 mcg
160 lb(73 kg)1043 mcg10950 mcg20857 mcg
180 lb(82 kg)1171 mcg12300 mcg23429 mcg
200 lb(91 kg)1300 mcg13650 mcg26000 mcg
220 lb(100 kg)1429 mcg15000 mcg28571 mcg
250 lb(113 kg)1614 mcg16950 mcg32286 mcg

💉 For exact syringe units based on your vial concentration, use the Vilon Reconstitution Calculator →

Administration

Route
Sublingual tablets or subcutaneous injection
Timing
Morning.
Fasting Required?
No — food timing not critical

Expected Timeline

Day 1-10 (course)
Neuroendocrine-immune balance restoration begins.
Month 3-6
Reduced inflammatory markers, improved T-reg function with repeat courses.

Who Is It For?

Neuroendocrine-Immune Axis

Low

Thymic dipeptide targeting T-regulatory cells and autonomic balance. Khavinson longevity protocol.

Reconstitution Example

Vial
5 mg
Water
2.5 mL
Concentration
2 mg/mL
Per Unit (100u syringe)
20 mcg
Dose of 1000 mcg = 50 units on a 100-unit insulin syringe

Safety & Considerations

Research peptide in Western markets. Extensively used in Russian clinical protocols. Excellent safety profile.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Interactions & Contraindications

Standard 10-30 day Khavinson cycles. No significant interactions documented. Oral or injectable. Can be combined with most bioregulators.

Synergies & Common Stacks

Vilon (immune/thymic) + Epitalon (pineal/telomerase) was the combination used in Khavinson's landmark 15-year mortality study, reducing death rates by 2×.

Vilon (thymus-specific) + Crystagen (broad immune) provide layered immune support — thymic T-cell maturation + innate/adaptive immune activation.

Dosing Quick Reference

Vilon— Dosing Guide
Dose Range
10-20 mg/day (oral/nasal) or 1-2 mg SC
Half-Life
~30 minutes (estimated)
Frequency
1× daily for 10-30 day cycles
Route
Subcutaneous
5 mg vial10 mg vial
💧 2.5 mL BAC water📐 2 mg/mL concentration💉 20 mcg/unit (100u syringe)
Khavinson Bioregulatorcalcmypeptide.com

Frequently Asked Questions

What is Vilon used for?
Vilon is a thymic dipeptide that restores neuroendocrine-immune axis balance. It reduces excess inflammation, promotes T-regulatory cell function, and improves autonomic balance. Used in Khavinson anti-aging immune protocols.

References

  1. Khavinson VKh, Morozov VG "Vilon (Lys-Glu) modulates immune and neuroendocrine function in aging".” Neuroendocrinology Letters (1999). PMID: 10521641

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Recommended SourceOral Bioregulator

Get Vilon from Vita-Stream — the comprehensive distributor for authentic Khavinson bioregulators. Oral capsules, no injections required.

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