Khavinson BioregulatorTarget: Adrenal glandsEndocrine

Glandokort

Adrenal Gland Extract Bioregulator · Adrenal Cytomax · Гландокорт

Glandokort is the Cytomax adrenal complex. Cortagen is not its pair - Cortagen is a brain-cortex tetrapeptide (AEDP). The similar names are a trap. This is adrenal cortex/medulla tissue, not a glucocorticoid drug.

Not FDA-approved - research chemical
Reviewed by CalcMyPeptide Editorial Team
Last updated: August 2026Evidence: Low4 peer-reviewed citations
Typical research dose
1-2 capsules/day
Frequency
1-2× daily for 10-30 day cycles
Half-life
Mixture (variable)
Common vials
N/A (oral)
CAS
N/A (biological extract)
Molecular weight
Mixture (<10 kDa)

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Longevity / aging3.5/10

    Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.

Compound card

Sequence
Adrenal glands peptide complex (mixture, not a single CAS)
Class
Khavinson Cytomax capsule complex (Adrenal glands)
Formula
Polypeptide extract (Adrenal tissue <10 kDa)
Status
Not FDA-approved · research use

How it works

Glandokort (A-17) is a Cytomax natural polypeptide extract from the adrenal glands of young calves, targeting the human adrenal cortex to restore the regulatory gene expression responsible for cortisol rhythm, DHEA production, and stress adaptation. The adrenal glands are the body's primary stress response organs: the cortex produces glucocorticoids (cortisol), mineralocorticoids (aldosterone), and androgens (DHEA), while the medulla releases adrenaline. Chronic stress, poor sleep, illness, or simply the passage of time causes progressive adrenal functional decline - commonly called "adrenal fatigue," though more precisely described as HPA-axis (hypothalamic-pituitary-adrenal) dysregulation.

Glandokort delivers short peptide signals (<10 kDa) extracted from bovine adrenal tissue. Unlike adaptogenic herbs (ashwagandha, rhodiola) that modulate cortisol receptors or stress signaling pathways, Glandokort works upstream: it relaxes age-silenced chromatin in adrenal cortex cells to reactivate the genes encoding steroidogenesis enzymes (StAR, CYP11A1, CYP21A2) and ACTH receptor density. This restores the adrenal gland's intrinsic capacity to mount an appropriate cortisol response rather than chronically over- or under-producing.

In the Khavinson longevity system, Glandokort is paired with Endoluten (A-8, pineal/melatonin) to address the full HPA axis reset - since the pineal gland sets the circadian master rhythm that determines the daily cortisol awakening response. Together they address both the upstream circadian control and the downstream adrenal output capacity.

Source: PMID: 15677927

Khavinson map

Canonical 41
Class
Cytomax (natural peptide complex)
Organ
Adrenal glands
Target
Adrenal glands
System
Endocrine
Sequence
Mixture / not a single CAS
Гландокорт

Used in bioregulator stacks

Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.

The Khavinson school

Vladimir Khatskelevich Khavinson (1946–2024) spent five decades at what became the St. Petersburg Institute of Bioregulation and Gerontology arguing a simple, stubborn idea: aging is, in part, a failure of tissue-specific peptide signals, and those signals can be restored. The first products were not “peptides” in the Instagram sense. They were Cytamins - polypeptide fractions isolated from a named organ of young animals. Later commercial refinements of those fractions are sold as Cytomaxes (Cytomed / NPCRIZ): still mixtures, still oral capsules, still defined by the source organ rather than a single sequence. When the group identified short active motifs inside those mixtures, they synthesized them as Cytogens - di-, tri-, and tetrapeptides with a one-letter code (KE, AEDG, KED, EDR, KEDP, and so on).

That three-layer stack is the whole map. Cytamin / pharmaceutical extracts (Thymalin, Epithalamin, Cortexin, Retinalamin, Prostatilen) are the clinic-era injectables registered in the former Soviet pharmacopeia. Cytomaxes are the capsule complexes Cytomed still lists as a 21-SKU organ line. Cytogens are the defined synthetics. English-language educators, including Brenden Henry’s public writing at Peptide Science Institute, add a further commercial distinction - later analog SKUs (N-acetyl, amidate, “V2” complexes) sold as more stable or more diverse than the original Cytomed lots. That last layer is a product taxonomy, not a Khavinson paper. We describe it so readers are not gaslit by three bottles with the same organ name. We do not reproduce paid Peptide Mastery protocols, Precision Cell Method language, or anyone else’s course IP.

Full Cytamin → Cytomax → Cytogen map, literature limits, and how we counted 41

The mechanism Khavinson published is epigenetic, not receptor-agonist in the GLP-1 sense. Short peptides are claimed to enter nuclei, interact with DNA/histones, and reopen tissue-specific transcription that condensed with age (heterochromatin → euchromatin). Reviews in the Bulletin of Experimental Biology and Medicine and Neuroendocrinology Letters (PMID 14523363, 15677927, 23888677) are the citable core. Complementary GI pharmacology is not mystical: di- and tripeptides are PEPT1/LAT substrates, which is why oral capsules are even a conversation. What is not established in Western Phase 3 programs is organ-by-organ disease treatment, telomere reversal as a clinical endpoint, or the manufacturer claim that Cytomax is “a third stronger” than Cytogen. Those are NPCRIZ marketing sentences.

Khavinson’s group published hundreds of papers, many in Russian, many in the same journal family. That is a real literature. It is also a literature with limited independent Western replication, small n, and a habit of using one review PMID as a stamp on every organ. On this site a leaf earns its organ story, its Cytomax↔Cytogen pair, its sequence if it has one, and an honest sentence about what has not been shown. Reconstitution math belongs on cytogens sold as vials. Cytomax capsules do not get a fake 5 mg vial.

The 41 we treat as canonical are the 21 Cytomaxes on the public e-peptide/Cytomed list, the 12 Cytogens on that same commercial line (including Vesilut, which Western catalogs often drop), plus eight historically load-bearing molecules that sit beside the capsule SKUs: Epitalon, Vilon, Thymogen, Livagen, Cortagen, Prostamax, Thymalin, and Epithalamin. Honluten, Cortexin, Retinalamin, Prostatilen, Thymulin, N-acetyl-epitalon-amidate, Pinalex, and the GPL Man / GPL Femme kits are covered as adjacent - same school or same storefront, not padded into a fake 41.

Public English-language teaching (including Brenden Henry at peptidescienceinstitute.com) is cited as context, not copied. Paid Peptide Mastery / Peptide Salvation text stays theirs.

History of this molecule

Adrenal aging is cortisol rhythm, DHEA, aldosterone, and medullary catecholamines all going off-script. Khavinson’s extract logic says the gland has peptide signals that keep steroidogenic enzyme transcription on. Glandokort is that Cytomax bet.

The naming collision with Cortagen is the most expensive pun in this catalog. Cortagen = cortex of the brain. Glandokort = adrenal. If you stack them because the letters look related, you stacked brain + adrenal by accident, which might even be a reasonable longevity stack - but not because the names match.

This is not hydrocortisone, not fludrocortisone, not an ACTH analog (cosyntropin). Addison’s and Cushing’s are not capsule diseases.

Caveats

Adrenal Cytomax is not a US dietary-supplement monograph and not a drug. The tissue-extract model means lot-to-lot composition is a fingerprint, not a single CAS number. English-language “V2” bottles that claim more peptide diversity are a later commercial layer (mass-spec marketing from specific brands) - they are not Khavinson’s 1990s papers. Animal-source capsules are inappropriate if the reader has a religious or allergy constraint on the source species. None of this replaces care for the actual organ disease. Do not taper prescribed steroids because a capsule exists.

Full 41-map: Khavinson bioregulators index · Bioregulator stacks

Research Use Cases

  • ✓Adrenal Cytomax identity
  • ✓Not HPA-axis restoration or stress-resilience treatment

Dosing

PhaseDoseFrequencyNotes
Mini-Course / General Preventive (1 box)2 capsules (20 mg)Once daily for 10 days, 30 min before breakfastStandard Khavinson mini-course (20 caps). Morning dosing is essential - aligns peptide signaling with the natural cortisol awakening response. Repeat every 6 months. Combine with Endoluten (A-8) for full HPA-axis reset.
Full Monthly Course (Burnout / Stress Recovery)2 capsules (20 mg)Twice daily for 30 days (120 caps = 2× 60-cap boxes)Bi-annual 30-day courses for adults with significant HPA dysregulation, burnout, or chronic fatigue. Core stack: Glandokort (A-17) + Endoluten (A-8) + Vladonix (A-6) for adrenal-immune-circadian reset.
Intensive / HPA Axis Restoration Protocol2 capsules (20 mg)Twice daily, repeated monthly as neededFor severe burnout, post-illness recovery, or chronic stress-induced adrenal insufficiency patterns. Physician supervision recommended. Does not replace medical treatment for Addison's disease or confirmed adrenal insufficiency. Max: 4 caps/day (40 mg).

Administration

Route / form
Oral capsules - swallowed with water. Cytomed Cytomaxes ship as capsules, not sublingual tablets and not lyophilized research vials.
Timing
Morning, with water, about 30 minutes before meals (empty stomach).
Empty stomach?
Yes - Empty stomach - about 30 minutes before meals. Cytomed boxes sometimes print “with food” because they are labeled as supplements; the manufacturer user-guide preference is before meals for absorption.

Glandokort: Not a research vial vs Oral capsule

Not a research vial
Bioavailability
Not applicable. This Cytomax SKU is not sold as a lyophilized research vial. There is no SubQ F% because Cytomed does not ship this complex as a cake.
Dose note
Do not reconstitute Glandokort. No BAC-water chart, no 5 mg vial math, no units-on-a-U-100 conversion. No dedicated cytogen on the 12-SKU NPCRIZ poster (none - Cortagen is cerebral cortex (AEDP), not cortisol). Do not invent one. There is no pharmaceutical-extract SKU that is this capsule in a syringe.
Advantages
  • No dedicated cytogen on the 12-SKU NPCRIZ poster (none - Cortagen is cerebral cortex (AEDP), not cortisol). Do not invent one.
  • There is no pharmaceutical-extract SKU that is this capsule in a syringe.
  • Do not reconstitute Glandokort. Cortagen vials are cortex cytogen, not adrenal. This is not hydrocortisone and not cosyntropin.
Considerations
  • Glandokort is an oral capsule complex. It is not a 5 mg lyophilized research vial.
  • Inventing recon math for a zero-mg Cytomax vial is how people inject the wrong product.
  • Not an official Cytomed sublingual tablet, IM ampoule, or eye drop either.
Oral capsule
Bioavailability
Not quantified in a Western PK study. Official Cytomed form is a swallowed capsule. PEPT1/LAT transport is class biology for short peptides, not an F% for this tissue mixture.
Dose note
Typical Cytomed labeling: 1–2 capsules daily in 10–30 day courses, swallowed with water about 30 minutes before meals (empty stomach). Manufacturer protocol, not an FDA label. Some boxes print “with food” because they are labeled as supplements; the timing copy we use is before meals.
Advantages
  • Official form for Glandokort: swallow the capsule with water. No reconstitution step and no 5 mg cake.
  • Adrenal Cytomax (Cytomed A-17). Cortagen is a brain-cortex tetrapeptide; the similar names are a trap, not a pair.
  • Course-based (10–30 days, a few times a year in manufacturer folklore), not a daily forever drug.
Considerations
  • Adrenal Cytomax is a peptide mixture / lot fingerprint, not a single CAS. English “V2” bottles are a later commercial layer, not a Khavinson RCT.
  • Russian school literature is not an FDA organ-disease label.
  • Third-party lingual SKUs exist in the wild. We do not claim sublingual as the official Cytomed Cytomax form.
Recommendation: Swallow Glandokort as oral capsules with water, about 30 minutes before meals. Adrenal Cytomax complex, not Cortagen, not a glucocorticoid, and not a research vial. No dedicated adrenal cytogen on the 12-SKU poster. Do not taper prescribed steroids because a capsule exists.

Timeline

Days 1–14
Improved morning energy, reduced "wired but tired" pattern. Early stabilization of cortisol rhythm reported.
Month 1–2
Improved stress resilience and reduction in afternoon energy crashes. Better DHEA:cortisol ratio.
Month 3–6
Sustained stress adaptation capacity. Many users report improved motivation, mood stability, and reduction in burnout symptoms.

Who it is for

Adrenal Fatigue / HPA-Axis Dysregulation

Low

Targets adrenal cortex gene expression. Restores steroidogenesis enzyme activity rather than providing exogenous hormone stimulation.

Chronic Stress / Burnout Recovery

Low

Works upstream of adaptogens by restoring adrenal cellular capacity. Best combined with Endoluten (A-8) for the full HPA-axis reset.

Safety & Considerations

Natural glandular extract (Cytomax) from bovine adrenal tissue, <10 kDa. Does not contain cortisol or active steroid hormones. Meets European/Russian veterinary standards. Generally recognized as safe.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • Cytomax SKUs are oral capsules. Do not run SubQ reconstitution math on a zero-mg vial.
  • Lot-to-lot composition is a fingerprint, not one sequence.
  • This site will not treat the named organ disease from a peptide page.
  • English-language V2 / analog bottles are a later commercial layer, not a Khavinson RCT.

Verdict

Glandokort is a Cytomax capsule complex from Adrenal glands. It is not the paired cytogen, not a 5 mg research cake, and not a US supplement monograph. The organ story is in the dossier on this page.

Interactions & Contraindications

Cushing and steroid therapy belong with a prescriber, not a capsule stack.

Frequently Asked Questions

Oral capsule or injection?▼
Glandokort is a Cytomax oral capsule: swallow with water, about 30 minutes before meals. It is not a 5 mg lyophilized research vial and not an official Cytomed sublingual tablet (third-party lingual SKUs exist in the wild). If you want a defined-sequence powder to reconstitute, that is the cytogen pair (none on the 12-SKU poster), not this complex. Do not run BAC math on a capsule SKU. Cortagen is cerebral cortex (AEDP), not cortisol. Do not taper prescribed steroids because a capsule exists.
Is Glandokort the same as Cortagen?▼
No. Glandokort is adrenal Cytomax. Cortagen is synthetic AEDP for cerebral cortex. Different organs.
Will this fix “adrenal fatigue”?▼
Adrenal fatigue is not a medical diagnosis. If cortisol is actually low or high, that is endocrinology.
Pair peptide?▼
NPCRIZ does not list a dedicated adrenal cytogen next to Glandokort the way Vesugen sits next to Ventfort. Do not invent one.
Capsule or vial?▼
Capsule complex. No reconstitution.
Does Glandokort contain cortisol?▼
No. Glandokort is filtered to <10 kDa, removing all hormones. It contains only short peptide signals that tell your adrenal gland cells to upregulate their own steroidogenesis gene expression. It does not flood the body with cortisol or DHEA.
What is the best stack for burnout recovery?▼
Glandokort (A-17) + Endoluten (A-8) + Vladonix (A-6) is the recommended Khavinson HPA-immune-circadian reset triple stack. Endoluten resets the master circadian clock (pineal), Glandokort restores adrenal response capacity, and Vladonix rebuilds immune surveillance often suppressed by chronic stress.

References

  1. Khavinson VKh et al. “Tissue-specific effects of peptides.” Bulletin of Experimental Biology and Medicine (2005). PMID: 15677927
  2. Khavinson VKh, Lin’kova NS, Tarnovskaya SI “Short peptides regulate gene expression.” Bulletin of Experimental Biology and Medicine (2013). PMID: 23888677
  3. Khavinson VKh, Morozov VG “Peptide regulation of aging: from experimental studies to clinical practice.” Advances in Gerontology (2003). PMID: 14523363
  4. Khavinson VKh “"Peptide bioregulators - a new class of geroprotectors".” Bulletin of Experimental Biology and Medicine (2002). PMID: 12677266

📚 Related Articles

Recommended sourceOral bioregulator

Get Glandokort from Vita-Stream - a distributor for Khavinson-line oral capsules. No reconstitution math on a Cytomax bottle.

Affiliate link · Full review