Gotratix
Muscle Extract Bioregulator · Skeletal Muscle Cytomax · Готратикс
Gotratix is the Cytomax skeletal-muscle complex - myocyte peptide fractions, not testosterone, not BPC-157, and not a myostatin antibody. The NPCRIZ copy even mentions triceps as the source tissue in some listings.
Use-case scores
0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.
- Longevity / aging3.5/10
Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.
- Injury & tissue3/10
Musculoskeletal aisle. Not BPC-157 and not an arthritis drug.
Compound card
- Sequence
- Skeletal muscle peptide complex (mixture, not a single CAS)
- Class
- Khavinson Cytomax capsule complex (Skeletal muscle)
- Formula
- Polypeptide extract (Skeletal muscle tissue <10 kDa)
- Status
- Not FDA-approved · research use
How it works
Gotratix (A-18) is a Cytomax natural polypeptide extract from the skeletal muscle tissue of young calves, delivering targeted peptide signals to human myocytes (muscle cells) to restore age-silenced gene expression controlling muscle protein synthesis, mitochondrial efficiency, and satellite cell (muscle stem cell) activation. Sarcopenia - the progressive, age-related loss of skeletal muscle mass and strength - begins as early as age 30 and accelerates dramatically after 50, with an estimated 3–8% decline per decade becoming 15% per decade after age 70.
The conventional counter-strategy is resistance training and protein intake, which work through IGF-1 and mTOR-mediated anabolic signaling. Gotratix operates at a more foundational level: it delivers epigenetic signals directly to myocyte nuclei to reactivate transcription of genes encoding myosin heavy chain isoforms, sarcomeric actin, mitochondrial biogenesis factors (PGC-1α), and satellite cell proliferation regulators. This is not a hormonal or pharmacological intervention - it is an epigenetic restoration of what the muscle cell's own gene program once expressed in youth.
Gotratix is used extensively by aging athletes, both to maintain performance and to accelerate recovery from training. In Khavinson's clinical protocols, it is most commonly paired with Bonomarlot (A-20, bone marrow) to address both muscle and blood cell regenerative capacity, and with Sigumir (A-4, cartilage/joints) for a complete locomotor system protocol.
Source: PMID: 15677927
Khavinson map
Canonical 41Used in bioregulator stacks
Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.
The Khavinson school
Vladimir Khatskelevich Khavinson (1946–2024) spent five decades at what became the St. Petersburg Institute of Bioregulation and Gerontology arguing a simple, stubborn idea: aging is, in part, a failure of tissue-specific peptide signals, and those signals can be restored. The first products were not “peptides” in the Instagram sense. They were Cytamins - polypeptide fractions isolated from a named organ of young animals. Later commercial refinements of those fractions are sold as Cytomaxes (Cytomed / NPCRIZ): still mixtures, still oral capsules, still defined by the source organ rather than a single sequence. When the group identified short active motifs inside those mixtures, they synthesized them as Cytogens - di-, tri-, and tetrapeptides with a one-letter code (KE, AEDG, KED, EDR, KEDP, and so on).
That three-layer stack is the whole map. Cytamin / pharmaceutical extracts (Thymalin, Epithalamin, Cortexin, Retinalamin, Prostatilen) are the clinic-era injectables registered in the former Soviet pharmacopeia. Cytomaxes are the capsule complexes Cytomed still lists as a 21-SKU organ line. Cytogens are the defined synthetics. English-language educators, including Brenden Henry’s public writing at Peptide Science Institute, add a further commercial distinction - later analog SKUs (N-acetyl, amidate, “V2” complexes) sold as more stable or more diverse than the original Cytomed lots. That last layer is a product taxonomy, not a Khavinson paper. We describe it so readers are not gaslit by three bottles with the same organ name. We do not reproduce paid Peptide Mastery protocols, Precision Cell Method language, or anyone else’s course IP.
Full Cytamin → Cytomax → Cytogen map, literature limits, and how we counted 41
The mechanism Khavinson published is epigenetic, not receptor-agonist in the GLP-1 sense. Short peptides are claimed to enter nuclei, interact with DNA/histones, and reopen tissue-specific transcription that condensed with age (heterochromatin → euchromatin). Reviews in the Bulletin of Experimental Biology and Medicine and Neuroendocrinology Letters (PMID 14523363, 15677927, 23888677) are the citable core. Complementary GI pharmacology is not mystical: di- and tripeptides are PEPT1/LAT substrates, which is why oral capsules are even a conversation. What is not established in Western Phase 3 programs is organ-by-organ disease treatment, telomere reversal as a clinical endpoint, or the manufacturer claim that Cytomax is “a third stronger” than Cytogen. Those are NPCRIZ marketing sentences.
Khavinson’s group published hundreds of papers, many in Russian, many in the same journal family. That is a real literature. It is also a literature with limited independent Western replication, small n, and a habit of using one review PMID as a stamp on every organ. On this site a leaf earns its organ story, its Cytomax↔Cytogen pair, its sequence if it has one, and an honest sentence about what has not been shown. Reconstitution math belongs on cytogens sold as vials. Cytomax capsules do not get a fake 5 mg vial.
The 41 we treat as canonical are the 21 Cytomaxes on the public e-peptide/Cytomed list, the 12 Cytogens on that same commercial line (including Vesilut, which Western catalogs often drop), plus eight historically load-bearing molecules that sit beside the capsule SKUs: Epitalon, Vilon, Thymogen, Livagen, Cortagen, Prostamax, Thymalin, and Epithalamin. Honluten, Cortexin, Retinalamin, Prostatilen, Thymulin, N-acetyl-epitalon-amidate, Pinalex, and the GPL Man / GPL Femme kits are covered as adjacent - same school or same storefront, not padded into a fake 41.
Public English-language teaching (including Brenden Henry at peptidescienceinstitute.com) is cited as context, not copied. Paid Peptide Mastery / Peptide Salvation text stays theirs.
History of this molecule
Sarcopenia is the honest use-case, not “violent hypertrophy.” Khavinson’s muscle line is epigenetic identity of myocytes and satellite-cell neighborhoods, not androgen receptor agonism. Gotratix is the complex. There is no famous muscle tetrapeptide on the 12-cytogen poster the way Pancragen is pancreas. Cartalax and Sigumir are cartilage/joint neighbors in the musculoskeletal aisle, not the same tissue.
Athlete marketing will try to sell Gotratix as a legal anabolic. That is how people get hurt - WADA, contamination, and false expectations. A tissue complex is not oxandrolone.
The origin papers are gerontology (age-related muscle) more than sports science. Trainers stacking this with CJC/ipa are mixing two completely different pharmacologies.
Caveats
Skeletal muscle Cytomax is not a US dietary-supplement monograph and not a drug. The tissue-extract model means lot-to-lot composition is a fingerprint, not a single CAS number. English-language “V2” bottles that claim more peptide diversity are a later commercial layer (mass-spec marketing from specific brands) - they are not Khavinson’s 1990s papers. Animal-source capsules are inappropriate if the reader has a religious or allergy constraint on the source species. None of this replaces care for the actual organ disease.
Full 41-map: Khavinson bioregulators index · Bioregulator stacks
Research Use Cases
- ✓Muscle Cytomax identity
- ✓Not sarcopenia prevention
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Mini-Course / General Preventive (1 box) | 2 capsules (20 mg) | Once daily for 10 days, 30 min before meals | Standard Khavinson mini-course (20 caps). Repeat every 6 months. Best combined with consistent resistance training for synergistic effect. Take in the morning or 30 min before primary training session. |
| Full Monthly Course (Anti-Sarcopenia / Performance) | 2 capsules (20 mg) | Twice daily for 30 days (120 caps = 2× 60-cap boxes) | Bi-annual 30-day courses for adults experiencing measurable muscle loss or athletes over 40. Core sarcopenia stack: Gotratix (A-18) + Sigumir (A-4, joints) + Bonomarlot (A-20, bone marrow) for complete locomotor system protocol. |
| Intensive / Muscle Recovery Protocol | 2 capsules (20 mg) | Twice daily, repeated monthly | Post-injury rehabilitation, rapid strength decline after illness/surgery, or progressive sarcopenia. Max: 4 caps/day (40 mg). Physician guidance for clinical use cases. |
Administration
Gotratix: Not a research vial vs Oral capsule
- No dedicated cytogen on the 12-SKU NPCRIZ poster (none on the 12-SKU list; Cartalax / Sigumir are cartilage neighbors). Do not invent one.
- There is no pharmaceutical-extract SKU that is this capsule in a syringe.
- A vial labeled Gotratix is a mis-ID. There is no famous muscle tetrapeptide on the 12-cytogen poster. Cartalax is cartilage (AED), not myocytes.
- Gotratix is an oral capsule complex. It is not a 5 mg lyophilized research vial.
- Inventing recon math for a zero-mg Cytomax vial is how people inject the wrong product.
- Not an official Cytomed sublingual tablet, IM ampoule, or eye drop either.
- Official form for Gotratix: swallow the capsule with water. No reconstitution step and no 5 mg cake.
- Skeletal-muscle Cytomax (Cytomed A-18). Catalogs misspell it Gotratrix - same capsule, still not a steroid.
- Course-based (10–30 days, a few times a year in manufacturer folklore), not a daily forever drug.
- Skeletal muscle Cytomax is a peptide mixture / lot fingerprint, not a single CAS. English “V2” bottles are a later commercial layer, not a Khavinson RCT.
- Russian school literature is not an FDA organ-disease label.
- Third-party lingual SKUs exist in the wild. We do not claim sublingual as the official Cytomed Cytomax form.
Timeline
Who it is for
Sarcopenia Prevention (Ages 40+)
LowRestores myocyte gene expression for myosin heavy chain isoforms and satellite cell proliferation - the upstream drivers of age-related muscle loss.
Athletic Recovery / Sports Performance
LowUsed by aging athletes for faster recovery and preservation of training adaptations. Works at the gene level, not receptor/hormone level.
Safety & Considerations
Natural glandular extract (Cytomax) from bovine skeletal muscle, <10 kDa. No anabolic hormones. Not a banned substance. Meets European/Russian veterinary standards. Generally recognized as safe.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- Cytomax SKUs are oral capsules. Do not run SubQ reconstitution math on a zero-mg vial.
- Lot-to-lot composition is a fingerprint, not one sequence.
- This site will not treat the named organ disease from a peptide page.
- English-language V2 / analog bottles are a later commercial layer, not a Khavinson RCT.
Verdict
Gotratix is a Cytomax capsule complex from Skeletal muscle. It is not the paired cytogen, not a 5 mg research cake, and not a US supplement monograph. The organ story is in the dossier on this page.
Interactions & Contraindications
Capsules skip vial math. Not a hypertrophy NDA.
Appears in goal guides
Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.
Ultimate Athletic Performance
Muscle and vascular cytomax plus BPC-157/TB-500 and GH secretagogues as they show up in athletic folklore. Injectable repair peptides are WADA-prohibited. This is not a doping pass.
Centenarian Decathlon Prep
Healthspan stack for muscle, cartilage, and VO2: Gotratix, Sigumir, Ventfort, plus MOTS-c. Inspired by Attia's marginal-decade idea, not a guarantee you die at 50 in a gym.
Frequently Asked Questions
Oral capsule or injection?▼
Is Gotratix anabolic?▼
Pair with Cartalax?▼
Reconstitution?▼
WADA?▼
Is Gotratix like growth hormone or steroids?▼
What is the best stack for muscle health?▼
References
- Khavinson VKh et al. “Tissue-specific effects of peptides.” Bulletin of Experimental Biology and Medicine (2005). PMID: 15677927
- Khavinson VKh, Lin’kova NS, Tarnovskaya SI “Short peptides regulate gene expression.” Bulletin of Experimental Biology and Medicine (2013). PMID: 23888677
- Khavinson VKh, Morozov VG “Peptide regulation of aging: from experimental studies to clinical practice.” Advances in Gerontology (2003). PMID: 14523363
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Get Gotratix from Vita-Stream - a distributor for Khavinson-line oral capsules. No reconstitution math on a Cytomax bottle.
Affiliate link · Full review