Sigumir
Cartilage & Bone Extract Bioregulator · Musculoskeletal Cytomax · Сигумир
Sigumir is the Cytomax cartilage/joint/spine complex. Cartalax (Ala-Glu-Asp) is the chondrocyte cytogen. This is not BPC-157, not a viscosupplement, and not a collagen powder.
Use-case scores
0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.
- Longevity / aging3.5/10
Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.
- Injury & tissue3/10
Musculoskeletal aisle. Not BPC-157 and not an arthritis drug.
Compound card
- Sequence
- Joints, cartilage, and spine peptide complex (mixture, not a single CAS)
- Class
- Khavinson Cytomax capsule complex (Joints, cartilage, and spine)
- Formula
- Polypeptide extract (Cartilage & Bone tissue <10 kDa)
- Status
- Not FDA-approved · research use
How it works
Sigumir (A-4) is a Cytomax natural polypeptide extract from the cartilage and bone tissue of young calves, targeting human chondrocytes, osteoblasts, and synovial cells to restore the gene expression governing collagen matrix synthesis, proteoglycan production, and anti-inflammatory joint signaling. Osteoarthritis affects approximately 250 million people globally and is fundamentally a disease of cartilage degradation: chondrocytes (cartilage cells) progressively lose their ability to synthesize type II collagen and aggrecan (the proteoglycan that gives cartilage its compressive strength), while simultaneously upregulating matrix metalloproteinases (MMP-13, ADAMTS-5) that degrade the extracellular matrix.
Sigumir delivers short peptide signals (<10 kDa) from bovine cartilage and bone tissue. These peptides enter chondrocyte and osteoblast nuclei to reactivate age-silenced genes encoding: type II collagen (COL2A1), aggrecan (ACAN), SOX9 (the master transcription factor for chondrocyte differentiation), and anti-inflammatory cytokines (IL-1Ra, which directly blocks the cartilage-destructive IL-1β signaling). Unlike glucosamine/chondroitin supplementation (which provides building block substrates), Sigumir works at the transcription level - it tells chondrocytes to re-express the genes for building these molecules.
In Khavinson's protocol, Sigumir (A-4, cartilage/bone) is combined with Gotratix (A-18, skeletal muscle) and Bonomarlot (A-20, bone marrow) to create the complete locomotor system protocol addressing cartilage, muscle, and blood cell regeneration simultaneously.
Source: PMID: 15677927
Khavinson map
Canonical 41Used in bioregulator stacks
Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.
The Khavinson school
Vladimir Khatskelevich Khavinson (1946–2024) spent five decades at what became the St. Petersburg Institute of Bioregulation and Gerontology arguing a simple, stubborn idea: aging is, in part, a failure of tissue-specific peptide signals, and those signals can be restored. The first products were not “peptides” in the Instagram sense. They were Cytamins - polypeptide fractions isolated from a named organ of young animals. Later commercial refinements of those fractions are sold as Cytomaxes (Cytomed / NPCRIZ): still mixtures, still oral capsules, still defined by the source organ rather than a single sequence. When the group identified short active motifs inside those mixtures, they synthesized them as Cytogens - di-, tri-, and tetrapeptides with a one-letter code (KE, AEDG, KED, EDR, KEDP, and so on).
That three-layer stack is the whole map. Cytamin / pharmaceutical extracts (Thymalin, Epithalamin, Cortexin, Retinalamin, Prostatilen) are the clinic-era injectables registered in the former Soviet pharmacopeia. Cytomaxes are the capsule complexes Cytomed still lists as a 21-SKU organ line. Cytogens are the defined synthetics. English-language educators, including Brenden Henry’s public writing at Peptide Science Institute, add a further commercial distinction - later analog SKUs (N-acetyl, amidate, “V2” complexes) sold as more stable or more diverse than the original Cytomed lots. That last layer is a product taxonomy, not a Khavinson paper. We describe it so readers are not gaslit by three bottles with the same organ name. We do not reproduce paid Peptide Mastery protocols, Precision Cell Method language, or anyone else’s course IP.
Full Cytamin → Cytomax → Cytogen map, literature limits, and how we counted 41
The mechanism Khavinson published is epigenetic, not receptor-agonist in the GLP-1 sense. Short peptides are claimed to enter nuclei, interact with DNA/histones, and reopen tissue-specific transcription that condensed with age (heterochromatin → euchromatin). Reviews in the Bulletin of Experimental Biology and Medicine and Neuroendocrinology Letters (PMID 14523363, 15677927, 23888677) are the citable core. Complementary GI pharmacology is not mystical: di- and tripeptides are PEPT1/LAT substrates, which is why oral capsules are even a conversation. What is not established in Western Phase 3 programs is organ-by-organ disease treatment, telomere reversal as a clinical endpoint, or the manufacturer claim that Cytomax is “a third stronger” than Cytogen. Those are NPCRIZ marketing sentences.
Khavinson’s group published hundreds of papers, many in Russian, many in the same journal family. That is a real literature. It is also a literature with limited independent Western replication, small n, and a habit of using one review PMID as a stamp on every organ. On this site a leaf earns its organ story, its Cytomax↔Cytogen pair, its sequence if it has one, and an honest sentence about what has not been shown. Reconstitution math belongs on cytogens sold as vials. Cytomax capsules do not get a fake 5 mg vial.
The 41 we treat as canonical are the 21 Cytomaxes on the public e-peptide/Cytomed list, the 12 Cytogens on that same commercial line (including Vesilut, which Western catalogs often drop), plus eight historically load-bearing molecules that sit beside the capsule SKUs: Epitalon, Vilon, Thymogen, Livagen, Cortagen, Prostamax, Thymalin, and Epithalamin. Honluten, Cortexin, Retinalamin, Prostatilen, Thymulin, N-acetyl-epitalon-amidate, Pinalex, and the GPL Man / GPL Femme kits are covered as adjacent - same school or same storefront, not padded into a fake 41.
Public English-language teaching (including Brenden Henry at peptidescienceinstitute.com) is cited as context, not copied. Paid Peptide Mastery / Peptide Salvation text stays theirs.
History of this molecule
Degenerative joint disease is where peptide vendors all show up with a different story. BPC-157 is a gastric fragment with wound-healing animal data. TB-500 is actin. Khavinson’s play is chondrocyte gene expression - proteoglycan and collagen-II transcription in aging cartilage. Sigumir is the complex; Cartalax is the tripeptide.
Spine in the marketing line means vertebral joints and disc-adjacent tissue in the extract logic, not “inject this into L5.” Oral complex. Not an epidural.
Caveats
Joint Cytomax is not a US dietary-supplement monograph and not a drug. The tissue-extract model means lot-to-lot composition is a fingerprint, not a single CAS number. English-language “V2” bottles that claim more peptide diversity are a later commercial layer (mass-spec marketing from specific brands) - they are not Khavinson’s 1990s papers. Animal-source capsules are inappropriate if the reader has a religious or allergy constraint on the source species. None of this replaces care for the actual organ disease.
Full 41-map: Khavinson bioregulators index · Bioregulator stacks
Research Use Cases
- ✓Musculoskeletal Cytomax vs Cartalax
- ✓Not osteoarthritis or osteoporosis treatment
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Mini-Course / General Preventive (1 box) | 2 capsules (20 mg) | Once daily for 10 days, 30 min before meals | Standard Khavinson mini-course (20 caps). Repeat every 6 months. Best combined with Gotratix (A-18, muscle) for the complete joint-muscle unit support. |
| Full Monthly Course (Joint Pain / OA) | 2 capsules (20 mg) | Twice daily for 30 days (120 caps = 2× 60-cap boxes) | Bi-annual 30-day courses for adults with osteoarthritis, joint pain, or significant cartilage loss. Core locomotor stack: Sigumir (A-4) + Gotratix (A-18) + Bonomarlot (A-20) per Khavinson locomotor system protocol. |
| Intensive / Joint Restoration Protocol | 2 capsules (20 mg) | Twice daily, repeated monthly as needed | For advanced osteoarthritis, post-operative joint recovery, or significant cartilage loss confirmed on imaging. Physician supervision advised. Max: 4 caps/day (40 mg). |
Administration
Sigumir: Not a research vial vs Oral capsule
- The defined-sequence vial in this aisle is the cytogen pair (Cartalax (AED)), a different SKU.
- There is no pharmaceutical-extract SKU that is this capsule in a syringe.
- Reconstitute Cartalax if you bought the AED vial. Intra-articular “Sigumir shots” are not a Cytomed protocol. This is not BPC-157.
- Sigumir is an oral capsule complex. It is not a 5 mg lyophilized research vial.
- Inventing recon math for a zero-mg Cytomax vial is how people inject the wrong product.
- Not an official Cytomed sublingual tablet, IM ampoule, or eye drop either.
- Official form for Sigumir: swallow the capsule with water. No reconstitution step and no 5 mg cake.
- Joint Cytomax (Cytomed A-4): chondrocyte aisle. Oral complex, not an epidural and not a viscosupplement. Gotratix is muscle.
- Course-based (10–30 days, a few times a year in manufacturer folklore), not a daily forever drug.
- Cartilage / joint / spine Cytomax is a peptide mixture / lot fingerprint, not a single CAS. English “V2” bottles are a later commercial layer, not a Khavinson RCT.
- Russian school literature is not an FDA organ-disease label.
- Third-party lingual SKUs exist in the wild. We do not claim sublingual as the official Cytomed Cytomax form.
Timeline
Who it is for
Osteoarthritis / Joint Health (Ages 45+)
LowRestores chondrocyte and osteoblast gene expression at the transcription level rather than just providing building block supplements like glucosamine.
Athletic Joint Preservation
LowFor high-load athletes seeking to slow cartilage wear. Best combined with Gotratix for complete joint-muscle support.
Safety & Considerations
Natural glandular extract (Cytomax) from bovine cartilage and bone tissue, <10 kDa. No hormones. Meets European/Russian veterinary standards. Generally recognized as safe.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- Cytomax SKUs are oral capsules. Do not run SubQ reconstitution math on a zero-mg vial.
- Lot-to-lot composition is a fingerprint, not one sequence.
- This site will not treat the named organ disease from a peptide page.
- English-language V2 / analog bottles are a later commercial layer, not a Khavinson RCT.
Verdict
Sigumir is a Cytomax capsule complex from Joints, cartilage, and spine. It is not the paired cytogen, not a 5 mg research cake, and not a US supplement monograph. The organ story is in the dossier on this page.
Interactions & Contraindications
This site will not treat joint disease from a peptide page.
Synergies & Common Stacks
Complex vs tripeptide.
Appears in goal guides
Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.
Frequently Asked Questions
Oral capsule or injection?▼
Sigumir vs Cartalax vs BPC-157?▼
Injections into the joint?▼
Pair with Gotratix?▼
Reconstitution?▼
How is Sigumir different from glucosamine/chondroitin?▼
What is the best stack for joints?▼
References
- Khavinson VKh et al. “Tissue-specific effects of peptides.” Bulletin of Experimental Biology and Medicine (2005). PMID: 15677927
- Khavinson VKh, Lin’kova NS, Tarnovskaya SI “Short peptides regulate gene expression.” Bulletin of Experimental Biology and Medicine (2013). PMID: 23888677
- Khavinson VKh, Morozov VG “Peptide regulation of aging: from experimental studies to clinical practice.” Advances in Gerontology (2003). PMID: 14523363
- Khavinson VKh “"Peptide bioregulators - a new class of geroprotectors".” Bulletin of Experimental Biology and Medicine (2002). PMID: 12677266
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Get Sigumir from Vita-Stream - a distributor for Khavinson-line oral capsules. No reconstitution math on a Cytomax bottle.
Affiliate link · Full review