Tabimorelin
Tabimorelin stands as a massively potent, orally active Growth Hormone Secretagogue (GHS) that pushed deep into Phase II clinical trials for severe adult GH deficiency. Operating as a highly engineered, true peptide-mimetic, it successfully breached the gastric barrier without requiring injection. While ultimately shelved by pharma in favor of highly profitable recombinant HGH, it remains a testament to elite secretagogue engineering designed to maximize natural pulsatile release.
Quick Stats
Scientific Data
Mechanism of Action
Tabimorelin (NN703) is a synthetic, orally active non-peptide growth hormone secretagogue (GHS). Like Ibutamoren (MK-677), it was designed to mimic ghrelin and bind to the ghrelin receptor (GHS-R1a) to stimulate a powerful, pulsatile release of naturally occurring human growth hormone (HGH) and IGF-1 from the pituitary gland.
It was developed as a potential oral treatment for age-related growth hormone deficiency (somatopause) and frailty. While it effectively raises IGF-1 levels, it holds lower affinity than MK-677 and development was largely paused in clinical trial phases.
Source: PMID: 11401563
Background & History
Tabimorelin (NN703) was developed by Novo Nordisk as a potential oral alternative to GH injections for growth hormone deficient adults. It entered Phase II clinical trials in the early 2000s showing dose-dependent GH elevation, but the magnitude of IGF-1 increase and clinical endpoints were modest compared to established GH replacement therapy. Development was discontinued, but tabimorelin remains an important reference compound in the growth hormone secretagogue field.
Research Use Cases
- ✓GH deficiency research
- ✓Oral GH secretagogue development
- ✓GHS-R1a pharmacology research
Dosing Protocol
| Typical Dose | 0.5-10 mg/day (oral) |
| Frequency | 1× daily (oral) |
| Half-Life | ~2 hours |
Dosing Protocols
Research / Clinical Trials
Body-Weight Dosing Reference
Estimated doses extrapolated from the published research range of 500–10000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.
| Weight | Low Dose | Target Dose | High Dose |
|---|---|---|---|
| 120 lb(54 kg) | 386 mcg | 4050 mcg | 7714 mcg |
| 140 lb(63 kg) | 450 mcg | 4725 mcg | 9000 mcg |
| 160 lb(73 kg) | 521 mcg | 5475 mcg | 10429 mcg |
| 180 lb(82 kg) | 586 mcg | 6150 mcg | 11714 mcg |
| 200 lb(91 kg) | 650 mcg | 6825 mcg | 13000 mcg |
| 220 lb(100 kg) | 714 mcg | 7500 mcg | 14286 mcg |
| 250 lb(113 kg) | 807 mcg | 8475 mcg | 16143 mcg |
💉 For exact syringe units based on your vial concentration, use the Tabimorelin Reconstitution Calculator →
Administration
Expected Timeline
Who Is It For?
Growth Hormone Secretagogue
LowHistorical interest; essentially a lesser-known, discontinued analogue conceptually identical to MK-677.
Safety & Considerations
Not FDA approved. Like all ghrelin mimetics, likely induces severe hunger and temporary insulin resistance.
Regulatory & Legal Status
Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.
Research Chemical
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Interactions & Contraindications
May increase cortisol and prolactin transiently. Similar drug interaction profile to other ghrelin mimetics — caution with insulin-sensitizing agents due to potential GH-mediated insulin resistance.
Synergies & Common Stacks
Both are oral GHS-R1a agonists. MK-677 is a non-peptide while tabimorelin is a peptide-mimetic — useful for comparing structural class effects on GH secretion patterns.
Tabimorelin and GHRP-2 share the GHS-R1a mechanism. Comparing oral (tabimorelin) vs injectable (GHRP-2) routes.
Dosing Quick Reference
Frequently Asked Questions
Is Tabimorelin a peptide?▼
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