CalcMyPeptide
Khavinson BioregulatorAlso known as: Lys-Glu-Asp, KED, Vascular Bioregulator

Vesugen

Vesugen (Lys-Glu-Asp) is a meticulously engineered Khavinson tripeptide bioregulator designed for extreme vascular intervention. Tasked primarily with restoring the elasticity and functionality of the endothelial lining, it is deployed in aggressive cardiovascular protocols to systematically reverse arterial hardening, halt the progression of atherosclerotic plaque, and profoundly normalize systemic blood flow in aging populations.

Reviewed by CalcMyPeptide Editorial Team
Last updated: April 2026Evidence: Low1 peer-reviewed citation

Quick Stats

Half-LifeShort (tripeptide)
Dose Range10-20 mg/day (oral) or 1-2 mg SC
Frequency1× daily for 10-30 day cycles
Vial Sizes5 mg, 10 mg
BioavailabilitySublingual or subcutaneous injection
Year Developed1990s

Scientific Data

Molecular Formula
C17H28N4O9
Molecular Weight
436.43 g/mol
CAS Number
PubChem ID

Mechanism of Action

Vesugen (Lys-Glu-Asp) is a tripeptide bioregulator targeting vascular endothelial cell gene expression. It promotes endothelial function restoration, reduces arterial stiffness, and supports angiogenic signaling. Khavinson studies show improved vascular markers, endothelial function, and cardiovascular biomarkers in aging animals and humans.

Source: PMID: 15677927

Background & History

Vesugen (Lys-Glu-Asp) targets vascular endothelium for eNOS and extracellular matrix maintenance.

Research Use Cases

  • Vascular health
  • Atherosclerosis prevention
  • Endothelial function restoration

Dosing Protocol

Typical Dose10-20 mg/day (oral) or 1-2 mg SC
Frequency1× daily for 10-30 day cycles
Half-Life~30 minutes (estimated)
Common Vial Sizes5 mg, 10 mg

Dosing Protocols

Khavinson Protocol

Dose
10 - 20 mg
Frequency
Daily SubQ for 10 days, 1-2x per year
Note: Vascular bioregulator. Often paired with Chelohart (cardiac) for comprehensive cardiovascular aging support.

Body-Weight Dosing Reference

Estimated doses extrapolated from the published research range of 100020000 mcg/day (referenced to 70 kg / 154 lb). These are approximations — consult a qualified healthcare provider for personalised guidance.

WeightLowTargetHigh
120 lb(54 kg)771 mcg8100 mcg15429 mcg
140 lb(63 kg)900 mcg9450 mcg18000 mcg
160 lb(73 kg)1043 mcg10950 mcg20857 mcg
180 lb(82 kg)1171 mcg12300 mcg23429 mcg
200 lb(91 kg)1300 mcg13650 mcg26000 mcg
220 lb(100 kg)1429 mcg15000 mcg28571 mcg
250 lb(113 kg)1614 mcg16950 mcg32286 mcg

💉 For exact syringe units based on your vial concentration, use the Vesugen Reconstitution Calculator →

Administration

Route
Sublingual tablets or subcutaneous injection
Timing
Morning.
Fasting Required?
No — food timing not critical

Expected Timeline

Day 1-10 (course)
Vascular endothelial gene expression restoration initiated.
Month 3-6
Improved endothelial function markers and arterial stiffness with repeat courses.

Who Is It For?

Vascular Aging / Endothelial Health

Low

Vascular endothelial bioregulator. Targets age-suppressed endothelial gene expression.

Reconstitution Example

Vial
5 mg
Water
2.5 mL
Concentration
2 mg/mL
Per Unit (100u syringe)
20 mcg
Dose of 1000 mcg = 50 units on a 100-unit insulin syringe

Safety & Considerations

Research peptide. Extensively used in Russian clinical protocols. Excellent safety profile in elderly populations.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change — verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Interactions & Contraindications

Standard Khavinson protocol.

Synergies & Common Stacks

Vesugen (synthetic) + Ventfort (vascular Cytomax) = comprehensive vascular support.

Vesugen (vessels) + Cardiogen (heart) = comprehensive cardiovascular bioregulator protocol.

Dosing Quick Reference

Vesugen— Dosing Guide
Dose Range
10-20 mg/day (oral) or 1-2 mg SC
Half-Life
~30 minutes (estimated)
Frequency
1× daily for 10-30 day cycles
Route
Subcutaneous
5 mg vial10 mg vial
💧 2.5 mL BAC water📐 2 mg/mL concentration💉 20 mcg/unit (100u syringe)
Khavinson Bioregulatorcalcmypeptide.com

Frequently Asked Questions

How does Vesugen differ from other cardiovascular peptides?
Vesugen targets vascular endothelial cell gene expression, reversing epigenetic aging of the vessel wall. Unlike acute vasodilators (VIP), Vesugen works at the transcriptional level for long-term endothelial restoration.

References

  1. Khavinson VKh et al. "Short peptide bioregulators for vascular aging".” Bulletin of Experimental Biology and Medicine (2009). PMID: 19503960

📚 Related Articles

Recommended SourceOral Bioregulator

Get Vesugen from Vita-Stream — the comprehensive distributor for authentic Khavinson bioregulators. Oral capsules, no injections required.

Affiliate link · Full review