Khavinson BioregulatorTarget: Blood vesselsCardiovascular

Ventfort

Blood Vessel Extract Bioregulator · Vascular Cytomax · Вентфорт

Ventfort is the Cytomax vascular complex - vessel-wall peptide fractions. Vesugen (Lys-Glu-Asp, KED) is the synthetic endothelial cytogen. Neither is a statin, an ACE inhibitor, or BPC-157.

Not FDA-approved - research chemical

Reviewed by CalcMyPeptide Editorial Team

·Last updated: August 2026·Evidence: Low·4 peer-reviewed citations

Typical research dose

1-2 capsules/day

Frequency

1-2× daily for 10-30 day cycles

Half-life

Mixture (variable)

Common vials

N/A (oral)

CAS

N/A (biological extract)

Molecular weight

Mixture (<10 kDa)

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Longevity / aging3.5/10
Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.

Compound card

Sequence: Blood vessels / endothelium peptide complex (mixture, not a single CAS)
Class: Khavinson Cytomax capsule complex (Blood vessels / endothelium)
Formula: Polypeptide extract (Vascular endothelial tissue <10 kDa)
Status: Not FDA-approved · research use

How it works

Ventfort (A-3) is a Cytomax natural polypeptide extract from the vascular endothelium of young calves - the third in Khavinson's A-Series, reflecting the cardiovascular system's centrality to every organ's function. Vascular aging is characterized by: progressive endothelial dysfunction (reduced nitric oxide bioavailability), arterial stiffening (increased pulse wave velocity), smooth muscle cell phenotype switching (from contractile to synthetic/inflammatory), and elevated oxidative stress in vessel walls. Endothelial dysfunction precedes atherosclerosis by decades and is detectable before any clinical cardiovascular event.

Ventfort delivers short peptide signals (<10 kDa) from bovine vascular endothelial tissue. These peptides enter endothelial cell and vascular smooth muscle cell nuclei to reactivate transcription of: eNOS (endothelial nitric oxide synthase - the primary source of vasodilatory NO), SIRT1 (sirtuin 1, which deacetylates and activates eNOS), VEGF receptor 2 (promoting neovascularization), and KLF2 (Kruppel-like factor 2, the endothelial shear stress transcription factor that maintains laminar flow protection). Together, these restore what Khavinson calls the "vascular gene program" lost with age.

Ventfort sits at the intersection of nearly every Khavinson organ bundle: it is paired with Chelohart (A-14) for the cardiovascular core, with Cerluten (A-5) and Svetinorm (A-7) for the CNS stack (since cerebrovascular perfusion is the rate-limiting factor for brain function), and with Suprefort (A-1) and Svetinorm (A-7) for the metabolic stack (since microvascular disease drives both pancreatic beta-cell failure and hepatic steatosis progression).

Source: PMID: 15677927

Khavinson map

Canonical 41

Class

Cytomax (natural peptide complex)

Organ

Blood vessels / endothelium

Target

Blood vessels

System

Cardiovascular

Sequence

Mixture / not a single CAS

Pair

Vesugen (KED)

Вентфорт

Used in bioregulator stacks

Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.

The Khavinson school

Vladimir Khatskelevich Khavinson (1946–2024) spent five decades at what became the St. Petersburg Institute of Bioregulation and Gerontology arguing a simple, stubborn idea: aging is, in part, a failure of tissue-specific peptide signals, and those signals can be restored. The first products were not “peptides” in the Instagram sense. They were Cytamins - polypeptide fractions isolated from a named organ of young animals. Later commercial refinements of those fractions are sold as Cytomaxes (Cytomed / NPCRIZ): still mixtures, still oral capsules, still defined by the source organ rather than a single sequence. When the group identified short active motifs inside those mixtures, they synthesized them as Cytogens - di-, tri-, and tetrapeptides with a one-letter code (KE, AEDG, KED, EDR, KEDP, and so on).

That three-layer stack is the whole map. Cytamin / pharmaceutical extracts (Thymalin, Epithalamin, Cortexin, Retinalamin, Prostatilen) are the clinic-era injectables registered in the former Soviet pharmacopeia. Cytomaxes are the capsule complexes Cytomed still lists as a 21-SKU organ line. Cytogens are the defined synthetics. English-language educators, including Brenden Henry’s public writing at Peptide Science Institute, add a further commercial distinction - later analog SKUs (N-acetyl, amidate, “V2” complexes) sold as more stable or more diverse than the original Cytomed lots. That last layer is a product taxonomy, not a Khavinson paper. We describe it so readers are not gaslit by three bottles with the same organ name. We do not reproduce paid Peptide Mastery protocols, Precision Cell Method language, or anyone else’s course IP.

Full Cytamin → Cytomax → Cytogen map, literature limits, and how we counted 41

The mechanism Khavinson published is epigenetic, not receptor-agonist in the GLP-1 sense. Short peptides are claimed to enter nuclei, interact with DNA/histones, and reopen tissue-specific transcription that condensed with age (heterochromatin → euchromatin). Reviews in the Bulletin of Experimental Biology and Medicine and Neuroendocrinology Letters (PMID 14523363, 15677927, 23888677) are the citable core. Complementary GI pharmacology is not mystical: di- and tripeptides are PEPT1/LAT substrates, which is why oral capsules are even a conversation. What is not established in Western Phase 3 programs is organ-by-organ disease treatment, telomere reversal as a clinical endpoint, or the manufacturer claim that Cytomax is “a third stronger” than Cytogen. Those are NPCRIZ marketing sentences.

Khavinson’s group published hundreds of papers, many in Russian, many in the same journal family. That is a real literature. It is also a literature with limited independent Western replication, small n, and a habit of using one review PMID as a stamp on every organ. On this site a leaf earns its organ story, its Cytomax↔Cytogen pair, its sequence if it has one, and an honest sentence about what has not been shown. Reconstitution math belongs on cytogens sold as vials. Cytomax capsules do not get a fake 5 mg vial.

The 41 we treat as canonical are the 21 Cytomaxes on the public e-peptide/Cytomed list, the 12 Cytogens on that same commercial line (including Vesilut, which Western catalogs often drop), plus eight historically load-bearing molecules that sit beside the capsule SKUs: Epitalon, Vilon, Thymogen, Livagen, Cortagen, Prostamax, Thymalin, and Epithalamin. Honluten, Cortexin, Retinalamin, Prostatilen, Thymulin, N-acetyl-epitalon-amidate, Pinalex, and the GPL Man / GPL Femme kits are covered as adjacent - same school or same storefront, not padded into a fake 41.

Public English-language teaching (including Brenden Henry at peptidescienceinstitute.com) is cited as context, not copied. Paid Peptide Mastery / Peptide Salvation text stays theirs.

History of this molecule

Khavinson’s vascular line treats aging as endothelial transcriptional decline - the lining of the pipe, not the cholesterol in the pipe. Ventfort is the complex; Vesugen is the tripeptide the group associated with vessel cells. English blogs then sell both as “blood pressure peptides,” which is a category error. Blood pressure is hemodynamics. This literature is cell-identity and capillary trophism.

The Soviet gerontology context included occupational vascular stress (including radiation and extreme environments in the origin myths). Treat those origin stories as history, not as a clinical trial in your living room. What you can cite is the tissue-specific peptide review family and later KED endothelial papers.

Do not stack Ventfort with every “cardio” SKU (Chelohart, Cardiogen, BPC, TB-500) and call it a protocol. Heart muscle, vessel wall, and nitric-oxide wound peptides are three different bets.

Caveats

Vascular Cytomax is not a US dietary-supplement monograph and not a drug. The tissue-extract model means lot-to-lot composition is a fingerprint, not a single CAS number. English-language “V2” bottles that claim more peptide diversity are a later commercial layer (mass-spec marketing from specific brands) - they are not Khavinson’s 1990s papers. Animal-source capsules are inappropriate if the reader has a religious or allergy constraint on the source species. None of this replaces care for the actual organ disease. Anticoagulated readers and people with unstable plaques do not get to treat a capsule as biologically inert just because it is “natural.”

Full 41-map: Khavinson bioregulators index · Bioregulator stacks

Research Use Cases

✓Vascular Cytomax vs Vesugen
✓Not endothelial restoration or atherosclerosis prevention

Dosing

Phase	Dose	Frequency	Notes
Mini-Course / General Preventive (1 box)	2 capsules (20 mg)	Once daily for 10 days, 30 min before meals	Standard Khavinson mini-course (20 caps). Repeat every 6 months from age 35. Combine with Chelohart (A-14) for core cardiovascular bundle.
Full Monthly Course (Cardiovascular / Vascular Health)	2 capsules (20 mg)	Twice daily for 30 days (120 caps = 2× 60-cap boxes)	Bi-annual 30-day treatment for cardiovascular risk factor management, hypertension, or early atherosclerosis. Core cardiovascular stack: Ventfort (A-3) + Chelohart (A-14) + Cerluten (A-5) for vascular-cardiac-cerebral protection.
Intensive / Vascular Restoration Protocol	2 capsules (20 mg)	Twice daily, repeated monthly	For significant endothelial dysfunction, established atherosclerosis, post-cardiac event recovery support, or peripheral vascular disease. Physician supervision mandatory. Complementary to - not a replacement for - cardiovascular medications. Max: 4 caps/day (40 mg).

Administration

Route / form

Oral capsules - swallowed with water. Cytomed Cytomaxes ship as capsules, not sublingual tablets and not lyophilized research vials.

Timing

Morning, with water, about 30 minutes before meals (empty stomach).

Empty stomach?

Yes - Empty stomach - about 30 minutes before meals. Cytomed boxes sometimes print “with food” because they are labeled as supplements; the manufacturer user-guide preference is before meals for absorption.

Ventfort: Not a research vial vs Oral capsule

Not a research vial

Bioavailability

Not applicable. This Cytomax SKU is not sold as a lyophilized research vial. There is no SubQ F% because Cytomed does not ship this complex as a cake.

Dose note

Do not reconstitute Ventfort. No BAC-water chart, no 5 mg vial math, no units-on-a-U-100 conversion. The defined-sequence vial in this aisle is the cytogen pair (Vesugen (KED)), a different SKU. There is no pharmaceutical-extract SKU that is this capsule in a syringe.

Advantages

The defined-sequence vial in this aisle is the cytogen pair (Vesugen (KED)), a different SKU.
There is no pharmaceutical-extract SKU that is this capsule in a syringe.
Reconstitute Vesugen if you bought the KED vial. A Ventfort-labeled cake is a mis-ID. This is not BPC-157 and not a statin.

Considerations

Ventfort is an oral capsule complex. It is not a 5 mg lyophilized research vial.
Inventing recon math for a zero-mg Cytomax vial is how people inject the wrong product.
Not an official Cytomed sublingual tablet, IM ampoule, or eye drop either.

Oral capsule

Bioavailability

Not quantified in a Western PK study. Official Cytomed form is a swallowed capsule. PEPT1/LAT transport is class biology for short peptides, not an F% for this tissue mixture.

Dose note

Typical Cytomed labeling: 1–2 capsules daily in 10–30 day courses, swallowed with water about 30 minutes before meals (empty stomach). Manufacturer protocol, not an FDA label. Some boxes print “with food” because they are labeled as supplements; the timing copy we use is before meals.

Advantages

Official form for Ventfort: swallow the capsule with water. No reconstitution step and no 5 mg cake.
Vessel-wall Cytomax (Cytomed A-3): endothelium aisle, not myocardium. Chelohart / Cardiogen are heart muscle.
Course-based (10–30 days, a few times a year in manufacturer folklore), not a daily forever drug.

Considerations

Vascular / endothelium Cytomax is a peptide mixture / lot fingerprint, not a single CAS. English “V2” bottles are a later commercial layer, not a Khavinson RCT.
Russian school literature is not an FDA organ-disease label.
Third-party lingual SKUs exist in the wild. We do not claim sublingual as the official Cytomed Cytomax form.

Recommendation: Swallow Ventfort as oral capsules with water, about 30 minutes before meals. Vascular Cytomax complex, not Vesugen powder and not Chelohart (myocardium). Pair: Vesugen (KED). Endothelial gene-expression literature is not a blood-pressure or MACE label.

Timeline

Days 1 - 14

Endothelial cell gene expression restoration initiated. Early improvement in resting blood pressure consistency reported.

Month 1–2

Improved arterial compliance markers. Better peripheral circulation and cold extremity reduction.

Month 3–6

Sustained eNOS and SIRT1 pathway restoration. Improved pulse wave velocity trend. Long-term cardiovascular risk trajectory support.

Who it is for

Cardiovascular / Vascular Aging (Ages 40+)

Low

Restores endothelial eNOS and KLF2 gene expression - the primary defense against vascular dysfunction and atherosclerosis initiation. Foundation of the Khavinsion cardiovascular bundle.

Hypertension / Arterial Stiffness

Low

Addresses the endothelial dysfunction underlying essential hypertension. Works complementarily with standard antihypertensive medications. Physician oversight required.

Safety & Considerations

Natural glandular extract (Cytomax) from bovine vascular tissue, <10 kDa. No hormones. Meets European/Russian veterinary standards. Generally recognized as safe.

Regulatory & Legal Status

FDA Status (US)

Research Only

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

Cytomax SKUs are oral capsules. Do not run SubQ reconstitution math on a zero-mg vial.
Lot-to-lot composition is a fingerprint, not one sequence.
This site will not treat the named organ disease from a peptide page.
English-language V2 / analog bottles are a later commercial layer, not a Khavinson RCT.

Verdict

Ventfort is a Cytomax capsule complex from Blood vessels / endothelium. It is not the paired cytogen, not a 5 mg research cake, and not a US supplement monograph. The organ story is in the dossier on this page.

Interactions & Contraindications

This site will not treat vascular disease from a peptide page.

Synergies & Common Stacks

+ Vesugen →

Complex vs sequence.

Appears in goal guides

Goal guides are maps, not clinic protocols. A mention here is not a treatment plan.

Ultimate Athletic Performance

Muscle and vascular cytomax plus BPC-157/TB-500 and GH secretagogues as they show up in athletic folklore. Injectable repair peptides are WADA-prohibited. This is not a doping pass.

View Protocol →

Cognitive Enhancement Protocol

Neuro 3 Plus bioregulator triad (brain, vessels, liver) plus Semax/Selank, with Dihexa reserved for advanced users.

View Protocol →

Centenarian Decathlon Prep

Healthspan stack for muscle, cartilage, and VO2: Gotratix, Sigumir, Ventfort, plus MOTS-c. Inspired by Attia's marginal-decade idea, not a guarantee you die at 50 in a gym.

View Protocol →

Frequently Asked Questions

Oral capsule or injection?▼

Ventfort is a Cytomax oral capsule: swallow with water, about 30 minutes before meals. It is not a 5 mg lyophilized research vial and not an official Cytomed sublingual tablet (third-party lingual SKUs exist in the wild). If you want a defined-sequence powder to reconstitute, that is the cytogen pair (Vesugen (KED)), not this complex. Do not run BAC math on a capsule SKU. Chelohart is myocardium, not vessels.

Ventfort vs Vesugen?▼

Ventfort is the vessel Cytomax complex. Vesugen is synthetic KED (Lys-Glu-Asp). Same organ map, different product class.

Will this lower blood pressure?▼

That is not a labeled indication and not a substitute for antihypertensives. The Khavinson claim is endothelial gene expression, not a dose-response BP curve like lisinopril.

Overlap with Chelohart?▼

Chelohart is heart muscle Cytomax. Ventfort is vessels. Cardiogen is the heart cytogen. Keep myocardium and endothelium straight.

Capsule or injection?▼

Ventfort is a capsule complex. Vesugen research vials are the injectable/synthetic form people reconstitute.

How is Ventfort different from L-arginine or other NO boosters?▼

L-arginine and NO boosters provide substrate (arginine) for eNOS to produce nitric oxide. Ventfort works at the gene expression level - it reactivates eNOS transcription itself via SIRT1 and KLF2, and restores the full endothelial gene program including VEGF receptor 2 for neovascularization.

Why is Ventfort A-3 - so high in importance?▼

The vascular system is the delivery infrastructure for every other organ system. Without healthy endothelial function, oxygen and nutrient delivery to the heart, brain, kidneys, and all other tissues degrades. Khavinson places vascular support as the third pillar (after pancreas and thyroid) because vascular dysfunction silently precedes nearly every age-related disease.

References

Khavinson VKh et al. “Tissue-specific effects of peptides.” Bulletin of Experimental Biology and Medicine (2005). PMID: 15677927
Khavinson VKh, Lin’kova NS, Tarnovskaya SI “Short peptides regulate gene expression.” Bulletin of Experimental Biology and Medicine (2013). PMID: 23888677
Khavinson VKh, Morozov VG “Peptide regulation of aging: from experimental studies to clinical practice.” Advances in Gerontology (2003). PMID: 14523363
Khavinson VKh “"Peptide bioregulators - a new class of geroprotectors".” Bulletin of Experimental Biology and Medicine (2002). PMID: 12677266

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